The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cell Membrane Lipid Rafts Mediate Caveolar Endocytosis of HIV-1 Tat Fusion Proteins
Open accessAbstract
The transactivator protein of human immunodeficiency virus type 1 Tat has the unique property of mediating the delivery of large protein cargoes into the cells when present in the extracellular milieu. Here we show that Tat fusion proteins are internalized by the cells through a temperature-dependent endocytic pathway that originates from cell membrane lipid rafts and follows caveolar endocytosis. These conclusions are supported by the study of the slow kinetics of the internalization of Tat endosomes, by their resistance to nonionic detergents, the colocalization of internalized Tat with markers of caveolar endocytosis, and the impairment of the internalization process by drugs that disrupt lipid rafts or disturb caveolar trafficking. These results are of interest for all those who exploit Tat as a vehicle for transcellular protein delivery.
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Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Tat trans-activates the human immunodeficiency virus through a nascent RNA target
Berkhout, B., Silverman, R. H., & Jeang, K.-T. (1989) · Cell · doi:10.1016/0092-8674(89)90289-4 · Cited by 647
Cited by
Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647
Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery
Khalil, I. A., Kogure, K., Akita, H., & Harashima, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.8 · Cited by 1,240
Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
Madani, F., Lindberg, S., Langel, Ü., Futaki, S., & Gräslund, A. (2011) · Journal of Biophysics · doi:10.1155/2011/414729 · Cited by 984
A Comprehensive Model for the Cellular Uptake of Cationic Cell‐penetrating Peptides
Duchardt, F., Fotin‐Mleczek, M., Schwarz, H., Fischer, R., & Brock, R. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00572.x · Cited by 771
Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
Morille, M., Passirani, C., Vonarbourg, A., Clavreul, A., & Benoit, J.-P. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.036 · Cited by 769
Metadata
- Authors
- Fittipaldi, A., Ferrari, A., Zoppé, M., Arcangeli, C., Pellegrini, V., Beltram, F., & Giacca, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 278
- Issue
- 36
- Pages
- 34141-34149
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2026405782
- Cited by
- 475
- References
- 2
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fittipaldi, A., Ferrari, A., Zoppé, M., Arcangeli, C., Pellegrini, V., Beltram, F., & Giacca, M. (2003). Cell Membrane Lipid Rafts Mediate Caveolar Endocytosis of HIV-1 Tat Fusion Proteins. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m303045200
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