Cited by 9,757Lipid Membrane Structure and BehaviorCaveolin-1 and cellular processesSphingolipid Metabolism and Signaling

Functional rafts in cell membranes

Simons, Kai, Ikonen, Elina·1997·Nature

Abstract

A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.

Integrity signals

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Crossref · 10.1038/42408

Cites

68 of 68 references verified0 citation errors · 0 not checkable

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  • VLCFAs increase membrane stiffness, thereby decreasing fluidity, and are likely critical for proper myelin function, myelination, myelin maintenance, and neuron polarity during CNS development.

    “VLCFAs increase membrane stiffness, thereby decreasing fluidity, and they are likely critical for proper myelin function [191,213,214,217], myelination [218], myelin maintenance [207,213,215], and neuron polarity during CNS development [219].”

    From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [217]

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Authors
Simons, K., & Ikonen, E.
Affiliations
European Molecular Biology Laboratory (DE)
Venue
Nature
Published
1997-06
Volume
387
Issue
6633
Pages
569-572
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2121936687
Cited by
9,757
References
68
Citations by year
2026: 168 · 2025: 188 · 2024: 208 · 2023: 223 · 2022: 240 · 2021: 263 · 2020: 293 · 2019: 274 · 2018: 278 · 2017: 289 · 2016: 312 · 2015: 344 · 2014: 343 · 2013: 347 · 2012: 388
FWCI
18.81
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords
lipid rafts, cell membrane structure, sphingolipids, cholesterol, lipid clustering, membrane fluidity, signal transduction, membrane trafficking
MeSH terms
Animals, Biological Transport, Cell Membrane, Cholesterol, Detergents, Golgi Apparatus, Humans, Membrane Lipids, Membrane Proteins, Solubility, Sphingolipids, Signal Transduction

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