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Functional Divergence of Human Cytoplasmic Myosin II
Open accessAbstract
Cytoplasmic (or non-muscle) myosin II isoforms are widely expressed molecular motors playing essential cellular roles in cytokinesis and cortical tension maintenance. Two of the three human non-muscle myosin II isoforms (IIA and IIB) have been investigated at the protein level. Transient kinetics of non-muscle myosin IIB showed that this motor has a very high actomyosin ADP affinity and slow ADP release. Here we report the kinetic characterization of the non-muscle myosin IIA isoform. Similar to non-muscle myosin IIB, non-muscle myosin IIA shows high ADP affinity and little enhancement of the ADP release rate by actin. The ADP release rate constant, however, is more than an order of magnitude higher than the steady-state ATPase rate. This implies that non-muscle myosin IIA spends only a small fraction of its ATPase cycle time in strongly actin-bound states, which is in contrast to non-muscle myosin IIB. Non-muscle myosin II isoforms thus appear to have distinct enzymatic properties that may be of importance in carrying out their cellular functions.
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Cites
Kinetic Mechanism and Regulation of Myosin VI
De La Cruz, E. M., Ostap, E. M., & Sweeney, H. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104136200 · Cited by 234
Cited by
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Vicente-Manzanares, M., Ma, X., Adelstein, R. S., & Horwitz, A. R. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2786 · Cited by 2,032
Force Generation, Transmission, and Integration during Cell and Tissue Morphogenesis
Lecuit, T., Lenne, P.-F., & Munro, E. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104027 · Cited by 621
Specificity of blebbistatin, an inhibitor of myosin II
Limouze, J., Straight, A. F., Mitchison, T., & Sellers, J. R. (2004) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-004-6060-7 · Cited by 386
Self-citationNonmuscle myosin II moves in new directions
Conti, M. A., & Adelstein, R. S. (2008) · Journal of Cell Science · doi:10.1242/jcs.007112 · Cited by 351
Biomechanical regulation of contractility: spatial control and dynamics
Levayer, R., & Lecuit, T. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.10.001 · Cited by 324
Metadata
- Authors
- Kovács, M., Wang, F., Hu, A., Zhang, Y., & Sellers, J. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 278
- Issue
- 40
- Pages
- 38132-38140
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1996788494
- Cited by
- 249
- References
- 1
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kovács, M., Wang, F., Hu, A., Zhang, Y., & Sellers, J. R. (2003). Functional Divergence of Human Cytoplasmic Myosin II. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m305453200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
