Distinct Pathways for the Trafficking of Angiotensin II and Adrenergic Receptors from the Endoplasmic Reticulum to the Cell Surface
Open accessAbstract
The molecular mechanism underlying the transport of G protein-coupled receptors from the endoplasmic reticulum (ER) to the cell surface is poorly understood. This issue was addressed by determining the role of Rab1, a Ras-related small GTPase that coordinates vesicular protein transport in the early secretory pathway, in the subcellular distribution and function of the angiotensin II type 1A receptor (AT1R), beta2-adrenergic receptor (AR), and alpha2B-AR in HEK293T cells. Inhibition of endogenous Rab1 function by transient expression of dominant-negative Rab1 mutants or Rab1 small interfering RNA (siRNA) induced a marked perinuclear accumulation and a significant reduction in cell-surface expression of AT1R and beta2-AR. The accumulated receptors were colocalized with calregulin (an ER marker) and GM130 (a Golgi marker), consistent with Rab1 function in regulating protein transport from the ER to the Golgi. In contrast, dominant-negative Rab1 mutants and siRNA had no effect on the subcellular distribution of alpha2B-AR. Similarly, expression of dominant-negative Rab1 mutants and siRNA depletion of Rab1 significantly attenuated AT1R-mediated inositol phosphate accumulation and ERK1/2 activation and beta2-AR-mediated ERK1/2 activation, but not alpha2B-AR-stimulated ERK1/2 activation. These data indicate that Rab1 GTPase selectively regulates intracellular trafficking and signaling of G protein-coupled receptors and suggest a novel, as yet undefined pathway for movement of G pro…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Loss of RAB1A/B impaired secretion.
“Loss of RAB1A/B impaired secretion (Fig. 6d,e), serving as a positive control3637.”
From Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival (2016) · cites this paper as [37]
Cites
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571 · see citing works
Takai, Y., Sasaki, T., & Matozaki, T. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.153 · Cited by 2,481 · see citing works
Ferguson, S. S. G. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01478-9 · Cited by 1,827 · see citing works
Endoplasmic Reticulum-Mediated Phagocytosis Is a Mechanism of Entry into Macrophages
Gagnon, É., Duclos, S., Rondeau, C., Chevet, É., Cameron, P. H., Steele‐Mortimer, O., Paiement, J. M., Bergeron, J. J. M., & Desjardins, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00797-3 · Cited by 683 · see citing works
The polyphosphoinositide phosphodiesterase of erythrocyte membranes
Downes, C. P., & Michell, R. H. (1981) · Biochemical Journal · doi:10.1042/bj1980133 · Cited by 610 · see citing works
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane
Downes, C. P., Mussat, M. C., & Michell, R. H. (1982) · Biochemical Journal · doi:10.1042/bj2030169 · Cited by 537 · see citing works
Claing, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00023-5 · Cited by 519 · see citing works
Tisdale, E. J., Bourne, J. R., Khosravi-Far, R., Der, C. J., & Balch, W. E. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.4.749 · Cited by 500 · see citing works
Rab1 Recruitment of p115 into a cis-SNARE Complex: Programming Budding COPII Vesicles for Fusion
Allan, B. B., Moyer, B. D., & Balch, W. E. (2000) · Science · doi:10.1126/science.289.5478.444 · Cited by 458 · see citing works
Dascher, C., & Balch, W. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42277-0 · Cited by 413 · see citing works
A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product
Gallwitz, D., Donath, C., & Sander, C. (1983) · Nature · doi:10.1038/306704a0 · Cited by 401 · see citing works
Plutner, H., Cox, A. D., Pind, S., Khosravi‐Far, R., Bourne, J. R., Schwaninger, R., Der, C. J., & Balch, W. E. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.1.31 · Cited by 392 · see citing works
The cyclophilin homolog ninaA is required in the secretory pathway
Colley, N. J., Baker, E. K., Stamnes, M. A., & Zuker, C. S. (1991) · Cell · doi:10.1016/0092-8674(91)90177-z · Cited by 324 · see citing works
Traffic Jam: A Compendium of Human Diseases that Affect Intracellular Transport Processes
Aridor, M., & Hannan, L. A. (2000) · Traffic · doi:10.1034/j.1600-0854.2000.011104.x · Cited by 279 · see citing works
Protein Sorting upon Exit from the Endoplasmic Reticulum
Muñiz, M., Morsomme, P., & Riezman, H. (2001) · Cell · doi:10.1016/s0092-8674(01)00215-x · Cited by 254 · see citing works
Rab1 Interaction with a GM130 Effector Complex Regulates COPII Vesicle cis‐Golgi Tethering
Moyer, B. D., Allan, B. B., & Balch, W. E. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.1o007.x · Cited by 251 · see citing works
Dwyer, N. D., Troemel, E. R., Sengupta, P., & Bargmann, C. I. (1998) · Cell · doi:10.1016/s0092-8674(00)81173-3 · Cited by 249 · see citing works
Martinez, O., & Goud, B. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00050-0 · Cited by 231 · see citing works
Nuoffer, C., Davidson, H. W., Matteson, J., Meinkoth, J. L., & Balch, W. E. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.2.225 · Cited by 230 · see citing works
Barak, L. S., Ferguson, S. S. G., Zhang, J., Martenson, C. H., Meyer, T., & Caron, M. G. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.2.177 · Cited by 219 · see citing works
Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin
Ferreira, P. A., Nakayama, T. A., Pak, W. L., & Travis, G. H. (1996) · Nature · doi:10.1038/383637a0 · Cited by 216 · see citing works
t-SNARE Activation Through Transient Interaction with a Rab-Like Guanosine Triphosphatase
Lupashin, V. V., & Waters, M. G. (1997) · Science · doi:10.1126/science.276.5316.1255 · Cited by 212 · see citing works
Yoo, J.-S., Moyer, B. D., Bannykh, S. I., Yoo, H.-M., Riordan, J. R., & Balch, W. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110263200 · Cited by 200 · see citing works
Dohlman, H. G., Bouvier, M., Benovic, J., Caron, M. G., & Lefkowitz, R. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47935-5 · Cited by 197 · see citing works
Hunyady, L., Baukal, A. J., Gáborik, Z., Olivares-Reyes, J. A., Bor, M., Szaszák, M., Lodge, R., Catt, K. J., & Balla, T. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200111013 · Cited by 173 · see citing works
Kallal, L. A., Gagnon, A. W., Penn, R. B., & Benovic, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.322 · Cited by 165 · see citing works
Seachrist, J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003657200 · Cited by 157 · see citing works
Lentiviral Vectors for Sustained Transgene Expression in Human Bone Marrow–Derived Stromal Cells
Zhang, X.-Y., Russa, V. F. L., Bao, L., Kolls, J. K., Schwarzenberger, P. O., & Reiser, J. (2002) · Molecular Therapy · doi:10.1006/mthe.2002.0585 · Cited by 156 · see citing works
Rab2 Is Essential for the Maturation of Pre-Golgi Intermediates
Tisdale, E. J., & Balch, W. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.29372 · Cited by 139 · see citing works
Interaction of Arrestins with Intracellular Domains of Muscarinic and α2-Adrenergic Receptors
Wu, G., Krupnick, J. G., Benovic, J., & Lanier, S. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17836 · Cited by 138 · see citing works
Self-citationSeachrist, J. L., Anborgh, P. H., & Ferguson, S. S. G. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61500-0 · Cited by 129 · see citing works
A Rab1 mutant affecting guanine nucleotide exchange promotes disassembly of the Golgi apparatus.
Wilson, B. S., Nuoffer, C., Meinkoth, J. L., McCaffery, M., Feramisco, J. R., Balch, W. E., & Farquhar, M. G. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.3.557 · Cited by 127 · see citing works
Multiple GTP-binding proteins regulate vesicular transport from the ER to Golgi membranes.
Schwaninger, R., Plutner, H., Bokoch, G., & Balch, W. E. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.5.1077 · Cited by 123 · see citing works
Blumer, J., Chandler, L. J., & Lanier, S. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112185200 · Cited by 116 · see citing works
Membrane Tethering and Fusion in the Secretory and Endocytic Pathways
Waters, M. G., & Hughson, F. M. (2000) · Traffic · doi:10.1034/j.1600-0854.2000.010802.x · Cited by 113 · see citing works
Wu, G., Bogatkevich, G. S., Mukhin, Y. V., Benovic, J., Hildebrandt, J. D., & Lanier, S. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9026 · Cited by 102 · see citing works
Self-citationReceptor Docking Sites for G-protein βγ Subunits
Wu, G., Benovic, J., Hildebrandt, J. D., & Lanier, S. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7197 · Cited by 98 · see citing works
Self-citationIncreased Myocardial Rab GTPase Expression
Wu, G., Yussman, M. G., Barrett, T. J., Hahn, H. S., Osińska, H. E., Hilliard, G. M., Wang, X., Toyokawa, T., Yatani, A., Lynch, R. A., et al. (2001) · Circulation Research · doi:10.1161/hh2401.100427 · Cited by 96 · see citing works
Self-citationSatoh, A. K., Tokunaga, F., Kawamura, S., & Ozaki, O. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.23.2943 · Cited by 95 · see citing works
Li, J., Benovic, J., & Liu‐Chen, L. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23112-6 · Cited by 94 · see citing works
Moore, R. H., Sadovnikoff, N., Hoffenberg, S., Liu, S., Woodford, P., Angelides, K. J., Trial, J., Carsrud, N. D. V., Dickey, B. F., & Knoll, B. J. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.9.2983 · Cited by 92 · see citing works
Volpicelli‐Daley, L. A., Lah, J. J., & Levey, A. I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106535200 · Cited by 80 · see citing works
Role of N-Glycosylation in the Expression and Functional Properties of Human AT1Receptor
Lanctôt, P. M., Leclerc, P. C., Escher, E., Leduc, R., & Guillemette, G. (1999) · Biochemistry · doi:10.1021/bi9830516 · Cited by 78 · see citing works
ε Protein Kinase C in Pathological Myocardial Hypertrophy
Wu, G., Toyokawa, T., Hahn, H. H., & Dorn, G. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000380200 · Cited by 77 · see citing works
Self-citationTisdale, E. J. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.6.1837 · Cited by 76 · see citing works
Genetic Defects of Intracellular-Membrane Transport
Olkkonen, V. M., & Ikonen, E. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010123431507 · Cited by 74 · see citing works
Dugan, J. M., deWit, C., McConlogue, L., & Maltese, W. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10982 · Cited by 65 · see citing works
N-Linked Glycosylation Is Required for Optimal AT1a Angiotensin Receptor Expression in COS-7 Cells
Jayadev, S., Smith, R. D., Jagadeesh, G., Baukal, A. J., Hunyady, L., & Catt, K. J. (1999) · Endocrinology · doi:10.1210/en.140.5.2010 · Cited by 49 · see citing works
Rab1a and Multiple Other Rab Proteins Are Associated with the Transcytotic Pathway in Rat Liver
Jin, M., Saucan, L., Farquhar, M. G., & Palade, G. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.30105 · Cited by 48 · see citing works
Regulation of G-Protein-Coupled Receptor Activity by Rab GTPases
Rosenfeld, J. L., Knoll, B. J., & Moore, R. H. (2002) · Receptors and Channels · doi:10.3109/10606820212398 · Cited by 46 · see citing works
Castellano, F., Wilson, A. L., & Maltese, W. A. (1995) · Journal of Receptors and Signal Transduction · doi:10.3109/10799899509049861 · Cited by 10 · see citing works
Hughes, R. J., Pasillas, M. P., Saiz, J., Jasper, J. R., & Insel, P. A. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)00005-0 · Cited by 7 · see citing works
Characterization of angiotensin II receptors (binding and mRNA) in the rat thyroid gland
Montiel, M., & Jiménez, E. (1998) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0200299 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
Mehta, P. K., & Griendling, K. K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2006 · Cited by 1,924 · see citing works
Karnik, S. S., Ünal, H., Kemp, J. R., Tirupula, K. C., Eguchi, S., Vanderheyden, P., & Thomas, W. G. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.010454 · Cited by 302 · see citing works
Regulation of G protein-coupled receptor export trafficking
Dong, C., Filipeanu, C. M., Duvernay, M. T., & Wu, G. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.008 · Cited by 280 · see citing works
Self-citationConn, P. M., Ulloa‐Aguirre, A., Ito, J., & Janovick, J. A. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.3.2 · Cited by 242 · see citing works
Duvernay, M. T., Zhou, F., & Wu, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313881200 · Cited by 163 · see citing works
Self-citationDupré, D. J., Robitaille, M., Éthier, N., Villeneuve, L. R., Mamarbachi, A. M., & Hébert, T. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605012200 · Cited by 152 · see citing works
The regulatory mechanisms of export trafficking of G protein-coupled receptors
Duvernay, M. T., Filipeanu, C. M., & Wu, G. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.05.020 · Cited by 148 · see citing works
Self-citationChaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics
Tao, Y., & Conn, P. M. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1121 · Cited by 146 · see citing works
Small GTP-binding protein-coupled receptors
Bhattacharya, M., Babwah, A. V., & Ferguson, S. S. G. (2004) · Biochemical Society Transactions · doi:10.1042/bst0321040 · Cited by 130 · see citing works
An escort for GPCRs: implications for regulation of receptor density at the cell surface
Achour, L., Labbé‐Jullié, C., Scott, M. G. H., & Marullo, S. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.07.009 · Cited by 112 · see citing works
Angiotensin II Signal Transduction Through Small GTP-Binding Proteins
Ohtsu, H., Suzuki, H., NAKASHIMA, H., Dhobale, S., Frank, G. D., Motley, E. D., & Eguchi, S. (2006) · Hypertension · doi:10.1161/01.hyp.0000237975.90870.eb · Cited by 94 · see citing works
Filipeanu, C. M., Zhou, F., Claycomb, W. C., & Wu, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405988200 · Cited by 89 · see citing works
Self-citationSmall GTPase regulation of GPCR anterograde trafficking
Wang, G., & Wu, G. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.09.002 · Cited by 79 · see citing works
Self-citationDong, C., & Wu, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605734200 · Cited by 70 · see citing works
Self-citationDuvernay, M. T., Dong, C., Zhang, X., Zhou, F., Nichols, C. D., & Wu, G. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.051623 · Cited by 70 · see citing works
Self-citationTargeting of the 5-HT1ASerotonin Receptor to Neuronal Dendrites Is Mediated by Yif1B
Carrel, D., Masson, J., Awabdh, S. A., Borg‐Capra, C., Lenkei, Z., Hamon, M., Emerit, M. B., & Darmon, M. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4487-07.2008 · Cited by 68 · see citing works
Signalling complexes associated with adenylyl cyclase II are assembled during their biosynthesis
Dupré, D. J., Baragli, A., Rebois, R. V., Éthier, N., & Hébert, T. E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.07.021 · Cited by 67 · see citing works
Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels
David, M., Richer, M., Mamarbachi, A. M., Villeneuve, L. R., Dupré, D. J., & Hébert, T. E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.05.014 · Cited by 64 · see citing works
Duvernay, M. T., Dong, C., Zhang, X., Robitaille, M., Hébert, T. E., & Wu, G. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00890.x · Cited by 64 · see citing works
Self-citationWang, G., Zhang, Z., Xu, Z. Z., Yin, H., Bai, L., Ma, Z., DeCoster, M. A., Qian, G., & Wu, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.002 · Cited by 64 · see citing works
Self-citationWang, G., Qian, P., Jackson, F. R., Qian, G., & Wu, G. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.08.008 · Cited by 62 · see citing works
Self-citationA Triple Arg Motif Mediates α2 B‐Adrenergi c Receptor Interaction with Sec 24 C /D and Export
Dong, C., Nichols, C. D., Guo, J., Huang, W. Y., Lambert, N. A., & Wu, G. (2012) · Traffic · doi:10.1111/j.1600-0854.2012.01351.x · Cited by 61 · see citing works
Self-citationDong, C., Yang, L., Zhang, X., Gu, H., Lam, M. L., Claycomb, W. C., Xia, H., & Wu, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081521 · Cited by 61 · see citing works
Self-citationDong, C., & Wu, G. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.07.017 · Cited by 59 · see citing works
Self-citationBiosynthesis and trafficking of seven transmembrane receptor signalling complexes
Dupré, D. J., & Hébert, T. E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.03.009 · Cited by 55 · see citing works
The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs
Li, C., Wei, Z., Fan, Y., Huang, W. Y., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M., & Wu, G. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.011 · Cited by 54 · see citing works
Self-citationRab26 Modulates the Cell Surface Transport of α2-Adrenergic Receptors from the Golgi
Li, C., Fan, Y., Lan, T.-H., Lambert, N. A., & Wu, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410936 · Cited by 54 · see citing works
Self-citationTransmembrane Signaling by G Protein–Coupled Receptors
Jacob, C., & Bunnett, N. W. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50006-4 · Cited by 53 · see citing works
Filipeanu, C. M., Zhou, F., Lam, M. L., Kerut, E. K., Claycomb, W. C., & Wu, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511460200 · Cited by 52 · see citing works
Self-citationFilipeanu, C. M., Zhou, F., Fugetta, E. K., & Wu, G. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.019984 · Cited by 52 · see citing works
Self-citationRay, K. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.02.006 · Cited by 50 · see citing works
Identification and Characterization of AGS4
Cao, X., Cismowski, M. J., Sato, M., Blumer, J., & Lanier, S. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312786200 · Cited by 50 · see citing works
Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice
Sharma, R., Ishimaru, Y., Davison, I. G., Ikegami, K., Chien, M., You, H., Chi, Q., Kubota, M., Yohda, M., Ehlers, M., et al. (2017) · eLife · doi:10.7554/elife.21895 · Cited by 49 · see citing works
Zhou, F., Filipeanu, C. M., Duvernay, M. T., & Wu, G. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.05.014 · Cited by 47 · see citing works
Self-citationSpecific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs
Wei, Z., Zhang, M., Li, C., Huang, W. Y., Fan, Y., Guo, J., Khater, M., Fukuda, M., Dong, Z., Hu, G., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.033 · Cited by 45 · see citing works
Self-citationFlowerdew, S. E., & Burgoyne, R. D. (2009) · Biochemical Journal · doi:10.1042/bj20081736 · Cited by 44 · see citing works
Zhang, X., Dong, C., Wu, Q., Balch, W. E., & Wu, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.222034 · Cited by 44 · see citing works
Self-citationDuvernay, M. T., Wang, H., Dong, C., Guidry, J. J., Sackett, D. L., & Wu, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.222323 · Cited by 43 · see citing works
Self-citationDong, C., Zhou, F., Fugetta, E. K., Filipeanu, C. M., & Wu, G. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.01.014 · Cited by 41 · see citing works
Self-citationADP-Ribosylation Factors Modulate the Cell Surface Transport of G Protein-Coupled Receptors
Dong, C., Zhang, X., Zhou, F., Dou, H., Duvernay, M. T., Zhang, P., & Wu, G. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.161489 · Cited by 41 · see citing works
Self-citationRab1 GTPase and Dimerization in the Cell Surface Expression of Angiotensin II Type 2 Receptor
Zhang, X., Wang, G., Dupré, D. J., Feng, Y., Robitaille, M., Lazartigues, E. D., Feng, Y., Hébert, T. E., & Wu, G. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.153460 · Cited by 41 · see citing works
Self-citationZhuang, X., Adipietro, K. A., Datta, S., Northup, J. K., & Ray, K. (2010) · Endocrinology · doi:10.1210/en.2010-0422 · Cited by 34 · see citing works
Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival
Redmann, V., Lamb, C. A., Hwang, S., Orchard, R. C., Kim, S., Razi, M., Milam, A., Park, S., Yokoyama, C. C., Kambal, A., et al. (2016) · Scientific Reports · doi:10.1038/srep23326 · Cited by 31 · see citing works
G-Protein-Coupled Receptor Interaction with Small GTPases
Dong, C., & Wu, G. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-407865-9.00006-6 · Cited by 31 · see citing works
Self-citationZhang, M., & Wu, G. (2018) · Traffic · doi:10.1111/tra.12624 · Cited by 31 · see citing works
Self-citationSakamoto, K., Wada, I., & Kimura, J. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.179762 · Cited by 30 · see citing works
Castillo‐Badillo, J. A., Sánchez-Reyes, O. B., Alfonzo‐Méndez, M. A., Romero‐Ávila, M. T., Reyes‐Cruz, G., & García-Sáinz, J. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121165 · Cited by 29 · see citing works
GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export
Zhang, M., Davis, J., Li, C., Gao, J., Huang, W. Y., Lambert, N. A., Terry, A. V., & Wu, G. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00009-16 · Cited by 28 · see citing works
Self-citationDong, C., Li, C., & Wu, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.267286 · Cited by 27 · see citing works
Self-citationAlam, J., deHaro, D. L., Redding, K., Ré, R. N., & Cook, J. L. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.09.002 · Cited by 25 · see citing works
Bertuccio, C. A., Lee, S.-L., Wu, G., Butterworth, M. B., Hamilton, K. L., & Devor, D. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092013 · Cited by 24 · see citing works
Self-citationG protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers
Khater, M., Wei, Z., Xu, X., Huang, W. Y., Lokeshwar, B. L., Lambert, N. A., & Wu, G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100325 · Cited by 24 · see citing works
Self-citationYin, H., Li, Q., Qian, G., Wang, Y., Li, Y., Wu, G., & Wang, G. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.11.010 · Cited by 24 · see citing works
Self-citationFunctional Characterization of Monomeric GTPase Rab1 in the Secretory Pathway of Leishmania
Bahl, S., Parashar, S., Malhotra, H., Raje, M., & Mukhopadhyay, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.670018 · Cited by 24 · see citing works
Nachmias, D., Sklan, E. H., Ehrlich, M., & Bacharach, E. (2012) · Retrovirology · doi:10.1186/1742-4690-9-7 · Cited by 24 · see citing works
Headless splice variant acting as dominant negative calcitonin receptor
Nag, K., Sultana, N., Kato, A., & Hirose, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.107 · Cited by 23 · see citing works
The mechanism and function of mitogen-activated protein kinase activation by ARF1
Zhou, F., Dong, C., Davis, J., Wu, W. H., Surrao, K., & Wu, G. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.06.007 · Cited by 23 · see citing works
Self-citationFerreira-Junior, M. D., Cavalcante, K. V. N., Ferreira, L. A., Lopes, P. R., Pontes, C. N. R., de Bessa, A. D. S. M., Neves, Â. R., Francisco, F. A., Pedrino, G. R., Xavier, C. H., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.018 · Cited by 22 · see citing works
Li, Y., Wang, G., Lin, K., Yin, H., Zhou, C., Liu, T., Wu, G., & Qian, G. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.04.009 · Cited by 22 · see citing works
Self-citationRole of Rab GTPases in the export trafficking of G protein-coupled receptors
Wang, G., Wei, Z., & Wu, G. (2017) · Small GTPases · doi:10.1080/21541248.2016.1277000 · Cited by 22 · see citing works
Self-citationKhater, M., Bryant, C. N., & Wu, G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100805 · Cited by 21 · see citing works
Self-citationYang, J., Sun, H., Zhang, J., Hu, M., Wang, J., Wu, G., & Wang, G. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.12045 · Cited by 20 · see citing works
Self-citationWei, Z., Xu, X., Fang, Y., Khater, M., Naughton, S. X., Hu, G., Terry, A. V., & Wu, G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100517 · Cited by 20 · see citing works
Self-citationAnterograde Trafficking of CXCR4 and CCR2 Receptors in a Prostate Cancer Cell Line
Gillies, K., Wertman, J. N., Charette, N., & Dupré, D. J. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350126 · Cited by 19 · see citing works
Maya‐Núñez, G., Ulloa‐Aguirre, A., Janovick, J. A., & Conn, P. M. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4765-4_14 · Cited by 19 · see citing works
Liu, Y., Shen, H., Wang, X.-Q.-Y., Liu, H.-Q., Zheng, L., & Luo, J. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26862 · Cited by 20 · see citing works
Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2
Zhang, M., Huang, W. Y., Gao, J., Terry, A. V., & Wu, G. (2016) · Scientific Reports · doi:10.1038/srep37921 · Cited by 18 · see citing works
Self-citationXu, X., Khater, M., & Wu, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1009380 · Cited by 17 · see citing works
Self-citationCharette, N., Holland, P., Frazer, J., Allen, H., & Dupré, D. J. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.06.008 · Cited by 17 · see citing works
Jaremko, K. M., Thompson, N. L., Reyes, B. A. S., Jin, J., Ebersole, B., Jenney, C. B., Grigson, P. S., Levenson, R. G., Berrettini, W. H., & Bockstaele, E. J. V. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.12.003 · Cited by 16 · see citing works
Analysis of Rab1 Function in Cardiomyocyte Growth
Filipeanu, C. M., Zhou, F., & Wu, G. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)38015-4 · Cited by 16 · see citing works
Self-citationZhang, X., Wang, H., Duvernay, M. T., Zhu, S., & Wu, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057805 · Cited by 15 · see citing works
Self-citationSequence-directed concentration of G protein-coupled receptors in COPII vesicles
Xu, X., Lambert, N. A., & Wu, G. (2023) · iScience · doi:10.1016/j.isci.2023.107969 · Cited by 14 · see citing works
Self-citationSpecific motifs mediate post-synaptic and surface transport of G protein-coupled receptors
Xu, X., Wei, Z., & Wu, G. (2021) · iScience · doi:10.1016/j.isci.2021.103643 · Cited by 13 · see citing works
Self-citationWilliams, D., & Devi, L. A. (2010) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(10)91005-3 · Cited by 13 · see citing works
Regulation of GPCR Anterograde Trafficking by Molecular Chaperones and Motifs
Young, B., Wertman, J. N., & Dupré, D. J. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.02.012 · Cited by 13 · see citing works
Donnellan, P. D., Kimbembe, C. C., Reid, H. M., & Kinsella, B. T. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.01.003 · Cited by 11 · see citing works
A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling
Zhu, S., Zhang, M., Davis, J., Wu, W. H., Surrao, K., Wang, H., & Wu, G. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.08.020 · Cited by 11 · see citing works
Self-citationRegulation of Post-Golgi Traffic of G Protein-Coupled Receptors
Wu, G. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4765-4_5 · Cited by 9 · see citing works
Self-citationHuman C1orf27 protein interacts with α2A-adrenergic receptor and regulates its anterograde transport
Xu, X., & Wu, G. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102021 · Cited by 9 · see citing works
Self-citationPotential Roles of SNX17, Rab11, and Rab5 in LDLR Recycling
Zhao, X., Long, S., Zhu, M., Hao, H., Liao, Y., Zhang, C., & Liu, Z. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.322498 · Cited by 8 · see citing works
Fan, Y., Li, C., Guo, J., Hu, G., & Wu, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050416 · Cited by 8 · see citing works
Self-citationSegregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction
Xu, X., Qiu, L., Zhang, M., & Wu, G. (2024) · Journal of Cell Science · doi:10.1242/jcs.261685 · Cited by 7 · see citing works
Self-citationEffects of agonists and phorbol esters on α1A-adrenergic receptor-Rab protein interactions
de-los-Santos-Cocotle, G., Martínez-Morales, J. C., Romero‐Ávila, M. T., Reyes‐Cruz, G., & García-Sáinz, J. A. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173423 · Cited by 6 · see citing works
Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila
Hutter, P. (2007) · Advances in genetics · doi:10.1016/s0065-2660(06)58001-0 · Cited by 6 · see citing works
Wu, G. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)38016-6 · Cited by 6 · see citing works
Self-citationCell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas
Huang, W. Y., Wu, G., & WANG, G.-Y. (2009) · Visual Neuroscience · doi:10.1017/s0952523809990277 · Cited by 5 · see citing works
Self-citationRegulation of α2B-Adrenerigc Receptor Export Trafficking by Specific Motifs
Wu, G., Davis, J., & Zhang, M. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.03.004 · Cited by 4 · see citing works
Self-citationGeometric Isomer of Guanabenz Confers Hepatoprotection to a Murine Model of Acetaminophen Toxicity
Xie, W., Jiang, R., Xie, J., Vince, R., & More, S. S. (2023) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.3c00047 · Cited by 3 · see citing works
Zhang, M., Xu, X., Li, C., Huang, W. Y., Xu, N., & Wu, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-46547-4 · Cited by 3 · see citing works
Self-citationGPCR Signaling from Intracellular Membranes
Jong, Y.-J. I., Harmon, S. K., & O’Malley, K. L. (2022) · doi:10.1002/9781119564782.ch8 · Cited by 3 · see citing works
Anterograde Trafficking of Nascent α2B-Adrenergic Receptor: Structural Basis, Roles of Small GTPases
Dong, C., & Wu, G. (2011) · Current topics in membranes · doi:10.1016/b978-0-12-384921-2.00004-5 · Cited by 2 · see citing works
Self-citationThe UFSP2-C1orf27 complex positions nascent GPCRs to the ufmylation system for ER export control
Xu, X., Fang, Y., Qiu, L., Huang, W., Li, H., & Wu, G. (2026) · iScience · doi:10.1016/j.isci.2026.115707 · Cited by 1 · see citing works
Self-citationSchellenberg, L. M., Regenthal, R., & Abraham, G. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174323 · Cited by 1 · see citing works
Ushio‐Fukai, M. (2009) · Wiley eBooks · doi:10.1002/9783527627585.ch14 · Cited by 1 · see citing works
The Role of Oligomerization in G Protein-Coupled Receptor Maturation
Kong, M. M. C., So, C. H., O’Dowd, B. F., & George, S. R. (2005) · Contemporary clinical neuroscience · doi:10.1007/978-1-59259-919-6_13 · Cited by 1 · see citing works
Functional Studies on α 2 -Adrenergic Receptor Subtypes
Sen, S. (2005)
Discovering G Protein-Coupled Receptor Motifs Mediating Export from the Endoplasmic Reticulum
Dong, C., & Wu, G. (2011) · Neuromethods · doi:10.1007/978-1-61779-179-6_8
Self-citationHammad, M. M. (2010) · Library and Archives Canada (Government of Canada)
Sivalingam, D., Amirshahi, S., Thyagarajan, K., Tofig, B., & Stein, M. (2011) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a001968.01
- Authors
- Wu, G., Zhao, G., & He, Y.
- Affiliations
- Louisiana State University (US)
- Louisiana State University Health Sciences Center New Orleans (US)
- Corresponding author
- Wu, Guangyu
- ORCID
- Wu, Guangyu
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 278
- Issue
- 47
- Pages
- 47062-47069
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2059443787
- Cited by
- 103
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 9 · 2014: 2 · 2013: 4 · 2012: 6
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- Rab1, G protein-coupled receptor trafficking, endoplasmic reticulum to Golgi transport, angiotensin II type 1a receptor, beta2-adrenergic receptor, alpha2B-adrenergic receptor, ERK1/2 activation, inositol phosphate accumulation, receptor subcellular distribution, HEK293T cells
- MeSH terms
- Animals, Cell Line, Cell Membrane, Endoplasmic Reticulum, Golgi Apparatus, Humans, Inositol Phosphates, Receptors, Adrenergic, Transfection, Receptors, Adrenergic, alpha-2, Receptors, Adrenergic, beta-2, rab1 GTP-Binding Proteins, Mitogen-Activated Protein Kinases, Protein Transport, Receptors, G-Protein-Coupled, Receptor, Angiotensin, Type 1, Mitogen-Activated Protein Kinase 3, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review