Distinct Pathways for the Trafficking of Angiotensin II and Adrenergic Receptors from the Endoplasmic Reticulum to the Cell Surface

TGF-β SIGNAL TRANSDUCTION

Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571

Small GTP-Binding Proteins

Takai, Y., Sasaki, T., & Matozaki, T. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.153 · Cited by 2,511

Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling

Ferguson, S. S. G. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01478-9 · Cited by 1,827

Endoplasmic Reticulum-Mediated Phagocytosis Is a Mechanism of Entry into Macrophages

Gagnon, É., Duclos, S., Rondeau, C., Chevet, É., Cameron, P. H., Steele‐Mortimer, O., Paiement, J. M., Bergeron, J. J. M., & Desjardins, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00797-3 · Cited by 683

The polyphosphoinositide phosphodiesterase of erythrocyte membranes

Downes, C. P., & Michell, R. H. (1981) · Biochemical Journal · doi:10.1042/bj1980133 · Cited by 610

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

Downes, C. P., Mussat, M. C., & Michell, R. H. (1982) · Biochemical Journal · doi:10.1042/bj2030169 · Cited by 537

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins

Claing, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00023-5 · Cited by 519

GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex

Tisdale, E. J., Bourne, J. R., Khosravi-Far, R., Der, C. J., & Balch, W. E. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.4.749 · Cited by 500

Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion

Allan, B. B., Moyer, B. D., & Balch, W. E. (2000) · Science · doi:10.1126/science.289.5478.444 · Cited by 418

Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus.

Dascher, C., & Balch, W. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42277-0 · Cited by 413

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system

Mehta, P. K., & Griendling, K. K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2006 · Cited by 1,924

International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli

Karnik, S. S., Ünal, H., Kemp, J. R., Tirupula, K. C., Eguchi, S., Vanderheyden, P., & Thomas, W. G. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.010454 · Cited by 313

Regulation of G protein-coupled receptor export trafficking

Dong, C., Filipeanu, C. M., Duvernay, M. T., & Wu, G. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.008 · Cited by 280

G Protein-Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo

Conn, P. M., Ulloa‐Aguirre, A., Ito, J., & Janovick, J. A. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.3.2 · Cited by 246

A Conserved Motif for the Transport of G Protein-coupled Receptors from the Endoplasmic Reticulum to the Cell Surface

Duvernay, M. T., Zhou, F., & Wu, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313881200 · Cited by 163

Seven Transmembrane Receptor Core Signaling Complexes Are Assembled Prior to Plasma Membrane Trafficking

Dupré, D. J., Robitaille, M., Éthier, N., Villeneuve, L. R., Mamarbachi, A. M., & Hébert, T. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605012200 · Cited by 152

The regulatory mechanisms of export trafficking of G protein-coupled receptors

Duvernay, M. T., Filipeanu, C. M., & Wu, G. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.05.020 · Cited by 148

Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics

Tao, Y., & Conn, P. M. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1121 · Cited by 149

Small GTP-binding protein-coupled receptors

Bhattacharya, M., Babwah, A. V., & Ferguson, S. S. G. (2004) · Biochemical Society Transactions · doi:10.1042/bst0321040 · Cited by 130

An escort for GPCRs: implications for regulation of receptor density at the cell surface

Achour, L., Labbé‐Jullié, C., Scott, M. G. H., & Marullo, S. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.07.009 · Cited by 112

Angiotensin II Signal Transduction Through Small GTP-Binding Proteins

Ohtsu, H., Suzuki, H., NAKASHIMA, H., Dhobale, S., Frank, G. D., Motley, E. D., & Eguchi, S. (2006) · Hypertension · doi:10.1161/01.hyp.0000237975.90870.eb · Cited by 94

Regulation of the Cell Surface Expression and Function of Angiotensin II Type 1 Receptor by Rab1-mediated Endoplasmic Reticulum-to-Golgi Transport in Cardiac Myocytes

Filipeanu, C. M., Zhou, F., Claycomb, W. C., & Wu, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405988200 · Cited by 89

Small GTPase regulation of GPCR anterograde trafficking

Wang, G., & Wu, G. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.09.002 · Cited by 81

Regulation of Anterograde Transport of α2-Adrenergic Receptors by the N Termini at Multiple Intracellular Compartments

Dong, C., & Wu, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605734200 · Cited by 70

Anterograde Trafficking of G Protein-Coupled Receptors: Function of the C-Terminal F(X)6LL Motif in Export from the Endoplasmic Reticulum

Duvernay, M. T., Dong, C., Zhang, X., Zhou, F., Nichols, C. D., & Wu, G. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.051623 · Cited by 70

Targeting of the 5-HT1ASerotonin Receptor to Neuronal Dendrites Is Mediated by Yif1B

Carrel, D., Masson, J., Awabdh, S. A., Borg‐Capra, C., Lenkei, Z., Hamon, M., Emerit, M. B., & Darmon, M. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4487-07.2008 · Cited by 68

Signalling complexes associated with adenylyl cyclase II are assembled during their biosynthesis

Dupré, D. J., Baragli, A., Rebois, R. V., Éthier, N., & Hébert, T. E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.07.021 · Cited by 67

Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels

David, M., Richer, M., Mamarbachi, A. M., Villeneuve, L. R., Dupré, D. J., & Hébert, T. E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.05.014 · Cited by 64

A Single Conserved Leucine Residue on the First Intracellular Loop Regulates ER Export of G Protein‐Coupled Receptors

Duvernay, M. T., Dong, C., Zhang, X., Robitaille, M., Hébert, T. E., & Wu, G. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00890.x · Cited by 64

Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia

Wang, G., Zhang, Z., Xu, Z. Z., Yin, H., Bai, L., Ma, Z., DeCoster, M. A., Qian, G., & Wu, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.002 · Cited by 64

Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells

Wang, G., Qian, P., Jackson, F. R., Qian, G., & Wu, G. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.08.008 · Cited by 62

A Triple Arg Motif Mediates α2 B‐Adrenergi c Receptor Interaction with Sec 24 C /D and Export

Dong, C., Nichols, C. D., Guo, J., Huang, W. Y., Lambert, N. A., & Wu, G. (2012) · Traffic · doi:10.1111/j.1600-0854.2012.01351.x · Cited by 61

Rab8 Interacts with Distinct Motifs in α2B- and β2-Adrenergic Receptors and Differentially Modulates Their Transport

Dong, C., Yang, L., Zhang, X., Gu, H., Lam, M. L., Claycomb, W. C., Xia, H., & Wu, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081521 · Cited by 62

Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases

Dong, C., & Wu, G. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.07.017 · Cited by 59

Biosynthesis and trafficking of seven transmembrane receptor signalling complexes

Dupré, D. J., & Hébert, T. E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.03.009 · Cited by 55

The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs

Li, C., Wei, Z., Fan, Y., Huang, W. Y., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M., & Wu, G. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.011 · Cited by 54

Rab26 Modulates the Cell Surface Transport of α2-Adrenergic Receptors from the Golgi

Li, C., Fan, Y., Lan, T.-H., Lambert, N. A., & Wu, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410936 · Cited by 54

Transmembrane Signaling by G Protein–Coupled Receptors

Jacob, C., & Bunnett, N. W. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50006-4 · Cited by 53

Enhancement of the Recycling and Activation of β-Adrenergic Receptor by Rab4 GTPase in Cardiac Myocytes

Filipeanu, C. M., Zhou, F., Lam, M. L., Kerut, E. K., Claycomb, W. C., & Wu, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511460200 · Cited by 52

Differential Regulation of the Cell-Surface Targeting and Function of β- and α1-Adrenergic Receptors by Rab1 GTPase in Cardiac Myocytes

Filipeanu, C. M., Zhou, F., Fugetta, E. K., & Wu, G. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.019984 · Cited by 52

Calcium-Sensing Receptor

Ray, K. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.02.006 · Cited by 50

Identification and Characterization of AGS4

Cao, X., Cismowski, M. J., Sato, M., Blumer, J., & Lanier, S. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312786200 · Cited by 50

Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice

Sharma, R., Ishimaru, Y., Davison, I. G., Ikegami, K., Chien, M., You, H., Chi, Q., Kubota, M., Yohda, M., Ehlers, M., et al. (2017) · eLife · doi:10.7554/elife.21895 · Cited by 49

Cell-surface targeting of α2-adrenergic receptors — Inhibition by a transport deficient mutant through dimerization

Zhou, F., Filipeanu, C. M., Duvernay, M. T., & Wu, G. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.05.014 · Cited by 47

Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs

Wei, Z., Zhang, M., Li, C., Huang, W. Y., Fan, Y., Guo, J., Khater, M., Fukuda, M., Dong, Z., Hu, G., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.033 · Cited by 46

A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels

Flowerdew, S. E., & Burgoyne, R. D. (2009) · Biochemical Journal · doi:10.1042/bj20081736 · Cited by 48

Di-acidic Motifs in the Membrane-distal C Termini Modulate the Transport of Angiotensin II Receptors from the Endoplasmic Reticulum to the Cell Surface

Zhang, X., Dong, C., Wu, Q., Balch, W. E., & Wu, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.222034 · Cited by 44

α2B-Adrenergic Receptor Interaction with Tubulin Controls Its Transport from the Endoplasmic Reticulum to the Cell Surface

Duvernay, M. T., Wang, H., Dong, C., Guidry, J. J., Sackett, D. L., & Wu, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.222323 · Cited by 43

Endoplasmic reticulum export of adrenergic and angiotensin II receptors is differentially regulated by Sar1 GTPase

Dong, C., Zhou, F., Fugetta, E. K., Filipeanu, C. M., & Wu, G. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.01.014 · Cited by 41

ADP-Ribosylation Factors Modulate the Cell Surface Transport of G Protein-Coupled Receptors

Dong, C., Zhang, X., Zhou, F., Dou, H., Duvernay, M. T., Zhang, P., & Wu, G. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.161489 · Cited by 41

Rab1 GTPase and Dimerization in the Cell Surface Expression of Angiotensin II Type 2 Receptor

Zhang, X., Wang, G., Dupré, D. J., Feng, Y., Robitaille, M., Lazartigues, E. D., Feng, Y., Hébert, T. E., & Wu, G. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.153460 · Cited by 42

Rab1 Small GTP-Binding Protein Regulates Cell Surface Trafficking of the Human Calcium-Sensing Receptor

Zhuang, X., Adipietro, K. A., Datta, S., Northup, J. K., & Ray, K. (2010) · Endocrinology · doi:10.1210/en.2010-0422 · Cited by 34

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

Redmann, V., Lamb, C. A., Hwang, S., Orchard, R. C., Kim, S., Razi, M., Milam, A., Park, S., Yokoyama, C. C., Kambal, A., et al. (2016) · Scientific Reports · doi:10.1038/srep23326 · Cited by 31

G-Protein-Coupled Receptor Interaction with Small GTPases

Dong, C., & Wu, G. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-407865-9.00006-6 · Cited by 31

Mechanisms of the anterograde trafficking of GPCRs: Regulation of AT1R transport by interacting proteins and motifs

Zhang, M., & Wu, G. (2018) · Traffic · doi:10.1111/tra.12624 · Cited by 32

Inhibition of Rab1 GTPase and Endoplasmic Reticulum-to-Golgi Trafficking Underlies Statin’s Toxicity in Rat Skeletal Myofibers

Sakamoto, K., Wada, I., & Kimura, J. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.179762 · Cited by 30

α1B-Adrenergic Receptors Differentially Associate with Rab Proteins during Homologous and Heterologous Desensitization

Castillo‐Badillo, J. A., Sánchez-Reyes, O. B., Alfonzo‐Méndez, M. A., Romero‐Ávila, M. T., Reyes‐Cruz, G., & García-Sáinz, J. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121165 · Cited by 31

GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export

Zhang, M., Davis, J., Li, C., Gao, J., Huang, W. Y., Lambert, N. A., Terry, A. V., & Wu, G. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00009-16 · Cited by 30

Regulation of α2B-Adrenergic Receptor-mediated Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Activation by ADP-ribosylation Factor 1

Dong, C., Li, C., & Wu, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.267286 · Cited by 27

C-terminal processing of GABARAP is not required for trafficking of the angiotensin II type 1A receptor

Alam, J., deHaro, D. L., Redding, K., Ré, R. N., & Cook, J. L. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.09.002 · Cited by 25

Anterograde Trafficking of KCa3.1 in Polarized Epithelia Is Rab1- and Rab8-Dependent and Recycling Endosome-Independent

Bertuccio, C. A., Lee, S.-L., Wu, G., Butterworth, M. B., Hamilton, K. L., & Devor, D. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092013 · Cited by 24

G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers

Khater, M., Wei, Z., Xu, X., Huang, W. Y., Lokeshwar, B. L., Lambert, N. A., & Wu, G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100325 · Cited by 24

Rab1 GTPase regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia

Yin, H., Li, Q., Qian, G., Wang, Y., Li, Y., Wu, G., & Wang, G. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.11.010 · Cited by 24

Functional Characterization of Monomeric GTPase Rab1 in the Secretory Pathway of Leishmania

Bahl, S., Parashar, S., Malhotra, H., Raje, M., & Mukhopadhyay, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.670018 · Cited by 24

Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway

Nachmias, D., Sklan, E. H., Ehrlich, M., & Bacharach, E. (2012) · Retrovirology · doi:10.1186/1742-4690-9-7 · Cited by 24

Headless splice variant acting as dominant negative calcitonin receptor

Nag, K., Sultana, N., Kato, A., & Hirose, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.107 · Cited by 23

The mechanism and function of mitogen-activated protein kinase activation by ARF1

Zhou, F., Dong, C., Davis, J., Wu, W. H., Surrao, K., & Wu, G. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.06.007 · Cited by 23

Postnatal early overfeeding induces cardiovascular dysfunction by oxidative stress in adult male Wistar rats

Ferreira-Junior, M. D., Cavalcante, K. V. N., Ferreira, L. A., Lopes, P. R., Pontes, C. N. R., de Bessa, A. D. S. M., Neves, Â. R., Francisco, F. A., Pedrino, G. R., Xavier, C. H., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.018 · Cited by 22

Rab1 GTPase promotes expression of β-adrenergic receptors in rat pulmonary microvascular endothelial cells

Li, Y., Wang, G., Lin, K., Yin, H., Zhou, C., Liu, T., Wu, G., & Qian, G. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.04.009 · Cited by 22

Role of Rab GTPases in the export trafficking of G protein-coupled receptors

Wang, G., Wei, Z., & Wu, G. (2017) · Small GTPases · doi:10.1080/21541248.2016.1277000 · Cited by 23

Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein–coupled receptor signaling to MAPK

Khater, M., Bryant, C. N., & Wu, G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100805 · Cited by 21

Regulation of β-Adrenergic Receptor Trafficking and Lung Microvascular Endothelial Cell Permeability by Rab5 GTPase

Yang, J., Sun, H., Zhang, J., Hu, M., Wang, J., Wu, G., & Wang, G. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.12045 · Cited by 20

Rab43 GTPase directs postsynaptic trafficking and neuron-specific sorting of G protein–coupled receptors

Wei, Z., Xu, X., Fang, Y., Khater, M., Naughton, S. X., Hu, G., Terry, A. V., & Wu, G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100517 · Cited by 21

Anterograde Trafficking of CXCR4 and CCR2 Receptors in a Prostate Cancer Cell Line

Gillies, K., Wertman, J. N., Charette, N., & Dupré, D. J. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350126 · Cited by 19

Pharmacological Chaperones Correct Misfolded GPCRs and Rescue Function: Protein Trafficking as a Therapeutic Target

Maya‐Núñez, G., Ulloa‐Aguirre, A., Janovick, J. A., & Conn, P. M. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4765-4_14 · Cited by 19

EndophilinA2 protects against angiotensin II‐induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes

Liu, Y., Shen, H., Wang, X.-Q.-Y., Liu, H.-Q., Zheng, L., & Luo, J. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26862 · Cited by 20

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2

Zhang, M., Huang, W. Y., Gao, J., Terry, A. V., & Wu, G. (2016) · Scientific Reports · doi:10.1038/srep37921 · Cited by 18

The olfactory receptor OR51E2 activates ERK1/2 through the Golgi-localized Gβγ-PI3Kγ-ARF1 pathway in prostate cancer cells

Xu, X., Khater, M., & Wu, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1009380 · Cited by 17

Dependence on different Rab GTPases for the trafficking of CXCR4 and CCR5 homo or heterodimers between the endoplasmic reticulum and plasma membrane in Jurkat cells

Charette, N., Holland, P., Frazer, J., Allen, H., & Dupré, D. J. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.06.008 · Cited by 17

Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons

Jaremko, K. M., Thompson, N. L., Reyes, B. A. S., Jin, J., Ebersole, B., Jenney, C. B., Grigson, P. S., Levenson, R. G., Berrettini, W. H., & Bockstaele, E. J. V. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.12.003 · Cited by 16

Analysis of Rab1 Function in Cardiomyocyte Growth

Filipeanu, C. M., Zhou, F., & Wu, G. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)38015-4 · Cited by 16

The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking

Zhang, X., Wang, H., Duvernay, M. T., Zhu, S., & Wu, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057805 · Cited by 15

Sequence-directed concentration of G protein-coupled receptors in COPII vesicles

Xu, X., Lambert, N. A., & Wu, G. (2023) · iScience · doi:10.1016/j.isci.2023.107969 · Cited by 14

Specific motifs mediate post-synaptic and surface transport of G protein-coupled receptors

Xu, X., Wei, Z., & Wu, G. (2021) · iScience · doi:10.1016/j.isci.2021.103643 · Cited by 13

Escorts Take the Lead

Williams, D., & Devi, L. A. (2010) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(10)91005-3 · Cited by 13

Regulation of GPCR Anterograde Trafficking by Molecular Chaperones and Motifs

Young, B., Wertman, J. N., & Dupré, D. J. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.02.012 · Cited by 14

Identification of a novel endoplasmic reticulum export motif within the eighth α-helical domain (α-H8) of the human prostacyclin receptor

Donnellan, P. D., Kimbembe, C. C., Reid, H. M., & Kinsella, B. T. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.01.003 · Cited by 11

A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling

Zhu, S., Zhang, M., Davis, J., Wu, W. H., Surrao, K., Wang, H., & Wu, G. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.08.020 · Cited by 11

Regulation of Post-Golgi Traffic of G Protein-Coupled Receptors

Wu, G. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4765-4_5 · Cited by 9

Human C1orf27 protein interacts with α2A-adrenergic receptor and regulates its anterograde transport

Xu, X., & Wu, G. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102021 · Cited by 9

Potential Roles of SNX17, Rab11, and Rab5 in LDLR Recycling

Zhao, X., Long, S., Zhu, M., Hao, H., Liao, Y., Zhang, C., & Liu, Z. (2025) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.125.322498 · Cited by 8

A Single Lys Residue on the First Intracellular Loop Modulates the Endoplasmic Reticulum Export and Cell-Surface Expression of α2A-Adrenergic Receptor

Fan, Y., Li, C., Guo, J., Hu, G., & Wu, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050416 · Cited by 8

Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction

Xu, X., Qiu, L., Zhang, M., & Wu, G. (2024) · Journal of Cell Science · doi:10.1242/jcs.261685 · Cited by 7

Effects of agonists and phorbol esters on α1A-adrenergic receptor-Rab protein interactions

de-los-Santos-Cocotle, G., Martínez-Morales, J. C., Romero‐Ávila, M. T., Reyes‐Cruz, G., & García-Sáinz, J. A. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173423 · Cited by 6

Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila

Hutter, P. (2007) · Advances in genetics · doi:10.1016/s0065-2660(06)58001-0 · Cited by 6

Regulation of the Trafficking and Function of G Protein‐Coupled Receptors by Rab1 GTPase in Cardiomyocytes

Wu, G. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)38016-6 · Cited by 6

Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas

Huang, W. Y., Wu, G., & WANG, G.-Y. (2009) · Visual Neuroscience · doi:10.1017/s0952523809990277 · Cited by 5

Regulation of α2B-Adrenerigc Receptor Export Trafficking by Specific Motifs

Wu, G., Davis, J., & Zhang, M. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.03.004 · Cited by 5

Geometric Isomer of Guanabenz Confers Hepatoprotection to a Murine Model of Acetaminophen Toxicity

Xie, W., Jiang, R., Xie, J., Vince, R., & More, S. S. (2023) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.3c00047 · Cited by 3

A Naturally Occurring Splice Variant of GGA1 Inhibits the Anterograde Post-Golgi Traffic of α2B-Adrenergic Receptor

Zhang, M., Xu, X., Li, C., Huang, W. Y., Xu, N., & Wu, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-46547-4 · Cited by 3

GPCR Signaling from Intracellular Membranes

Jong, Y.-J. I., Harmon, S. K., & O’Malley, K. L. (2022) · Wiley eBooks · doi:10.1002/9781119564782.ch8 · Cited by 3

Anterograde Trafficking of Nascent α2B-Adrenergic Receptor: Structural Basis, Roles of Small GTPases

Dong, C., & Wu, G. (2011) · Current topics in membranes · doi:10.1016/b978-0-12-384921-2.00004-5 · Cited by 2

The UFSP2-C1orf27 complex positions nascent GPCRs to the ufmylation system for ER export control

Xu, X., Fang, Y., Qiu, L., Huang, W., Li, H., & Wu, G. (2026) · iScience · doi:10.1016/j.isci.2026.115707 · Cited by 1

The Rho kinase (ROCK) inhibitor Y-27632 reduces the β2-adrenoceptor density but enhance cAMP formation in primary equine bronchial epithelial cells

Schellenberg, L. M., Regenthal, R., & Abraham, G. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174323 · Cited by 1

Aspects of Nox/Duox Signaling

Ushio‐Fukai, M. (2009) · Wiley eBooks · doi:10.1002/9783527627585.ch14 · Cited by 1

The Role of Oligomerization in G Protein-Coupled Receptor Maturation

Kong, M. M. C., So, C. H., O’Dowd, B. F., & George, S. R. (2005) · Contemporary clinical neuroscience · doi:10.1007/978-1-59259-919-6_13 · Cited by 1

Functional Studies on α 2 -Adrenergic Receptor Subtypes

Sen, S. (2005)

Discovering G Protein-Coupled Receptor Motifs Mediating Export from the Endoplasmic Reticulum

Dong, C., & Wu, G. (2011) · Neuromethods · doi:10.1007/978-1-61779-179-6_8

CHARACTERIZATION OF THE ANGIOTENSIN TYPE 1 RECEPTOR AND THE BETA2 ADRENERGIC RECEPTOR PROPERTIES: THE INVOLVEMENT OF ARRESTIN2, RAB1 AND SOME MOLECULAR CHAPERONES IN THE ASSEMBLY AND TRAFFICKING OF GPCRS

Hammad, M. M. (2010) · Library and Archives Canada (Government of Canada)

Rab1a

Sivalingam, D., Amirshahi, S., Thyagarajan, K., Tofig, B., & Stein, M. (2011) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a001968.01

Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases

Dong, C., & Wu, G. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.07.017 · Cited by 59

Rab1 GTPase and Dimerization in the Cell Surface Expression of Angiotensin II Type 2 Receptor

Zhang, X., Wang, G., Dupré, D. J., Feng, Y., Robitaille, M., Lazartigues, E. D., Feng, Y., Hébert, T. E., & Wu, G. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.153460 · Cited by 42

Differential regulation of the export of G protein‐coupled receptors from the endoplasmic reticulum by a GTP‐restricted Sar1 GTPase mutant

Zhou, F., & Wu, G. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.4.a249

Differential Regulation of the Cell-Surface Targeting and Function of β- and α1-Adrenergic Receptors by Rab1 GTPase in Cardiac Myocytes

Filipeanu, C. M., Zhou, F., Fugetta, E. K., & Wu, G. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.019984 · Cited by 52

Roles of Rab1 GTPase and dimerization in the cell surface transport of angiotensin II type 2 receptor

Zhang, X., Dupré, D. J., Feng, Y., Hébert, T. E., & Wu, G. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.945.6