The DOI matches its Crossref record.
Plasma Membrane Ca2+ ATPase 4 Is Required for Sperm Motility and Male Fertility
Open accessAbstract
Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility. Furthermore, the PMCA inhibitor 5-(and-6)-carboxyeosin diacetate succinimidyl ester reduced sperm motility in wild-type animals, thus mimicking the effects of PMCA4 deficiency on sperm motility and supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca(2+) levels.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Calcium Pumps in Health and Disease
Brini, M., & Carafoli, E. (2009) · Physiological Reviews · doi:10.1152/physrev.00032.2008 · Cited by 676
Blomberg Jensen, M., Nielsen, J. E., Jorgensen, A., Rajpert-De Meyts, E., Kristensen, D. M., Jorgensen, N., Skakkebaek, N. E., Juul, A., & Leffers, H. (2010) · Human Reproduction · doi:10.1093/humrep/deq024 · Cited by 354
Vitamin D and male reproduction
Jensen, M. B. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.262 · Cited by 242
Extracellular vesicles as personalized medicine
Beetler, D. J., Di Florio, D. N., Bruno, K. A., Ikezu, T., March, K. L., Cooper, L. T., Wolfram, J., & Fairweather, D. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101155 · Cited by 101
Metadata
- Authors
- Schuh, K., Cartwright, E. J., Jankevics, E., Bundschu, K., Liebermann, J., Williams, J. C., Armesilla, A. L., Emerson, M., Oceandy, D., Knobeloch, K.-P., & Neyses, L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 279
- Issue
- 27
- Pages
- 28220-28226
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2104174115
- Cited by
- 268
- References
- 0
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Plasma Membrane Ca2+ ATPase 4 Is Required for Sperm Motility and Male Fertility. https://app.cochat.ai/papers/10.1074/jbc.m312599200
- The paper
- Schuh, K., Cartwright, E. J., Jankevics, E., Bundschu, K., Liebermann, J., Williams, J. C., Armesilla, A. L., Emerson, M., Oceandy, D., Knobeloch, K.-P., & Neyses, L. (2004). Plasma Membrane Ca2+ ATPase 4 Is Required for Sperm Motility and Male Fertility. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m312599200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
