Extracellular vesicles as personalized medicine
Open accessAbstract
Extracellular vesicles (EVs) are released from all cells in the body, forming an important intercellular communication network that contributes to health and disease. The contents of EVs are cell source-specific, inducing distinct signaling responses in recipient cells. The specificity of EVs and their accumulation in fluid spaces that are accessible for liquid biopsies make them highly attractive as potential biomarkers and therapies for disease. The duality of EVs as favorable (therapeutic) or unfavorable (pathological) messengers is context dependent and remains to be fully determined in homeostasis and various disease states. This review describes the use of EVs as biomarkers, drug delivery vehicles, and regenerative therapeutics, highlighting examples involving viral infections, cancer, and neurological diseases. There is growing interest to provide personalized therapy based on individual patient and disease characteristics. Increasing evidence suggests that EV biomarkers and therapeutic approaches are ideal for personalized medicine due to the diversity and multifunctionality of EVs.
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It is possible that virus-containing EVs may be taken up by cells that do not express ACE2 using surface ligands on EVs.
“Additionally, it is possible that virus-containing EVs may be taken up by cells that do not express ACE2 using surface ligands on EVs.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [51]
Section 3.1 (page unavailable) reports that viral material, including SARS-CoV-2 RNA, can be found in EVs and that viruses can use EV receptors rather than their own receptors to enter host cells. It does not specifically establish uptake of virus-containing EVs by cells lacking ACE2 through EV surface ligands. (LLM, conf=0.78)
Experimental — accuracy not yet measuredBoth the mRNA against the SARS-CoV-2 spike protein and the lipid nanoparticle vehicle could provide the adjuvant effect needed to promote myocarditis following vaccination with an mRNA vaccine.
“Possibly both the mRNA against the SARS-CoV-2 spike protein and the lipid nanoparticle vehicle could provide the adjuvant effect needed to promote myocarditis following vaccination with an mRNA vaccine. 35,51,198”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [51]
Section 3.1 discusses extracellular vesicles, SARS-CoV-2 infection, and immune activation; section 4.3 discusses nanoparticles as drug-delivery vehicles. Neither addresses whether vaccine mRNA or its lipid nanoparticle vehicle could act as an adjuvant that promotes myocarditis. Searches for myocarditis, lipid nanoparticles, and mRNA-vaccine adjuvant effects found no passage making that connection; page numbers were unavailable in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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- Authors
- Beetler, D. J., Di Florio, D. N., Bruno, K. A., Ikezu, T., March, K. L., Cooper, L. T., Wolfram, J., & Fairweather, D.
- Affiliations
- Mayo Clinic (US)
- University of Florida (US)
- Mayo Clinic in Florida (US)
- The University of Queensland (AU)
- Corresponding author
- Fairweather, DeLisa
- ORCID
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2023-06
- Volume
- 91
- Pages
- 101155
- ISSN
- 0098-2997 (ISSN-L)
- PMC
- PMC10073244
- OpenAlex
- W4310099811
- Cited by
- 101
- References
- 265
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 28 · 2023: 20
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Aspects of Medicine (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- Funders
- American Heart Association (R01 HL164520, 20TPA35490415, TL1 TR002380, R21 AI154927, R21 AI145356, R21 AI163302, R21 AI152318)
- Ionis Pharmaceuticals
- National Institutes of Health (20TPA35490415, UL1TR002556, AI154927, TR002380, TL1TR002380, UL1TR002377)
- Advanced Research Projects Agency
- National Institute on Aging (R01AG066429, RF1AG054199, R01AG054672, R01AG067763, R01AG072719, R01AG054199, R01AG076537)
- National Heart, Lung, and Blood Institute (HL164520, R01HL164520)
- National Institute of Allergy and Infectious Diseases (R21AI145356, 20TPA35490415, AI145356, R21AI163302, R21AI152318, R21AI154927)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- extracellular vesicles, personalized medicine, liquid biopsy, biomarkers, drug carriers, intercellular communication, viral infection, cancer, neurological disorders
- MeSH terms
- Extracellular Vesicles, Liquid Biopsy, Humans, Biomarkers, Drug Delivery Systems, Precision Medicine
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