The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Copper Binding to the Amyloid-β (Aβ) Peptide Associated with Alzheimer's Disease
Open accessAbstract
There is now direct evidence that copper is bound to amyloid-beta peptide (Abeta) in senile plaque of Alzheimer's disease. Copper is also linked with the neurotoxicity of Abeta and free radical damage, and Cu(2+) chelators represent a possible therapy for Alzheimer's disease. We have therefore used a range of complementary spectroscopies to characterize the coordination of Cu(2+) to Abeta in solution. The mode of copper binding is highly pH-dependent. EPR spectroscopy indicates that both coppers have axial, Type II coordination geometry, square-planar or square-pyramidal, with nitrogen and oxygen ligands. Circular dichroism studies indicate that copper chelation causes a structural transition of Abeta. Competition studies with glycine and l-histidine indicate that copper binds to Abeta-(1-28) at pH 7.4 with an affinity of K(a) approximately 10(7) m(-1). (1)H NMR indicates that histidine residues are involved in Cu(2+) coordination but that Tyr(10) is not. Studies using analogues of Abeta-(1-28) in which each of the histidine residues have been replaced by alanine or in which the N terminus is acetylated suggest that the N terminus and His(13) are crucial for Cu(2+) binding and that His(6) and His(14) are also implicated. Evidence for the link between Alzheimer's disease and Cu(2+) is growing, and our studies have made a significant contribution to understanding the mode of Cu(2+) binding to Abeta in solution.
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Cites
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Cited by
Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729
The redox chemistry of the Alzheimer's disease amyloid β peptide
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Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide
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Copper in the brain and Alzheimer’s disease
Hung, Y. H., Bush, A. I., & Cherny, R. A. (2010) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-009-0600-y · Cited by 498
Kozlowski, H., Janicka-Klos, A., Brasun, J., Gaggelli, E., Valensin, D., & Valensin, G. (2009) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2009.05.011 · Cited by 469
Metadata
- Authors
- Syme, C. D., Nadal, R. C., Rigby, S. E. J., & Viles, J. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 279
- Issue
- 18
- Pages
- 18169-18177
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2009833553
- Cited by
- 460
- References
- 11
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Syme, C. D., Nadal, R. C., Rigby, S. E. J., & Viles, J. H. (2004). Copper Binding to the Amyloid-β (Aβ) Peptide Associated with Alzheimer's Disease. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m313572200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
