Copper, iron and zinc in Alzheimer's disease senile plaques
Abstract
Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) patients and in the neuropil of the amygdala of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE). Comparison of SP rim and core values revealed no significant differences between levels of Cu, Fe or Zn. Zinc and Fe in SP rims and cores were significantly elevated in AD compared with AD neuropil (P<0.05). Copper was significantly elevated (P<0.05) in the rim of SP compared with AD neuropil. Comparison of AD and control neuropil revealed a significant (P<0.05) elevation of Zn in AD subjects. The elevation of these elements in SP in AD is of interest in light of the observation that Cu, Fe and particularly Zn, can accelerate aggregation of amyloid beta peptide.
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Bio-available metals (copper, zinc, and iron) are found in high concentration in amyloid plaques.
“Post-mortem examination of the brain suggested that bio-available metals (i.e., copper, zinc, and iron) are found in high concentration in the amyloid plaques.”
From The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity (2013) · cites this paper as [12]
These metal ions have been shown to promote Aβ40 aggregation.
“Thus, these metal ions have been shown to promote Aβ40 aggregation,23–27,29–32”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [23]
Remarkably high concentrations of Zn, Cu, and Fe have been found within the amyloid deposits in AD-affected brains.
“Remarkably high concentrations of Zn, Cu, and Fe have been found within the amyloid deposits in AD-affected brains,23,24”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [23]
This is in contrast with a large number of reports showing the aggregation-promoting effect of metal ions on the Aβ peptide.
“This is in contrast with a large number of reports showing the aggregation-promoting effect of metal ions on the Aβ peptide.23–27,29–32,37,38”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [23]
Unusually high concentrations of copper, iron, and zinc are found within amyloid deposits in AD-affected brains.
“unusually high concentrations of copper, iron, and zinc have been found within the amyloid deposits in AD-affected brains.11”
From Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity (2014) · cites this paper as [11]
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- Authors
- Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R.
- Affiliations
- University of Kentucky (US)
- University of Guelph (CA)
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 158
- Issue
- 1
- Pages
- 47-52
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2083500052
- Cited by
- 2,120
- References
- 72
- Citations by year
- 2026: 38 · 2025: 52 · 2024: 69 · 2023: 82 · 2022: 100 · 2021: 92 · 2020: 95 · 2019: 103 · 2018: 80 · 2017: 94 · 2016: 87 · 2015: 82 · 2014: 89 · 2013: 96 · 2012: 116
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (2-PO1-AG05119, P01AG005119, 5-P50 AG0514)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, amyloid plaques, copper, iron, zinc, trace elements, amygdala, amyloid-beta aggregation, neuropil
- MeSH terms
- Alzheimer Disease, Amygdala, Copper, Humans, Iron, Spectrometry, X-Ray Emission, Zinc, Neuropil, Biotinylation, Plaque, Amyloid
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