The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

Efficient selection for high-expression transfectants with a novel eukaryotic vector

Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,149

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation.

Yang, Y., Dudoit, S., Luu, P., Lin, D., Peng, V., Ngai, J., & Speed, T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.e15 · Cited by 3,722

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924

Nicotinamide improves NAD + levels to protect against acetaminophen-induced acute liver injury in mice

Xu, J., Zhang, L., Jiang, R., Hu, K., Hu, D., Liao, C., Jiang, S., Yang, Y., Huang, J., Tang, L. P., et al. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211014573 · Cited by 13

Regular exercise effectively protects against the aging-associated decline in skeletal muscle NAD content

Chubanava, S., & Treebak, J. T. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112109 · Cited by 16

SIRT1 Regulation—It Ain't All NAD

Chao, L. C., & Tontonoz, P. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.12.017 · Cited by 13

Caloric excess or restriction mediated modulation of metabolic enzyme acetylation—proposed effects on cardiac growth and function

Sack, M. N. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.032 · Cited by 13

Sirtuins in Aging and Age-Related Diseases

Haigis, M. C., & Sinclair, D. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00011-7 · Cited by 13

Overexpression of miR-182 inhibits ossification of ligamentum flavum cells by targeting NAMPT

Zhang, Q., Shen, Y., Jiang, Y., Zhao, S., Zhou, D., & Xu, N. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.03.008 · Cited by 13

Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis

Brandl, L., Zhang, Y., Kirstein, N., Sendelhofert, A., Boos, S. L., Jung, P., Greten, F. R., Rad, R., & Menssen, A. (2019) · Neoplasia · doi:10.1016/j.neo.2019.07.009 · Cited by 15

Risks and rewards of targeting NAD+ homeostasis in the brain

Li, C., & Wu, L. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111545 · Cited by 14

The Governance of Management Consultancy Use: Practices, Problems, and Possibilities

Sturdy, A. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-72128-2_16 · Cited by 13

WldS Reduces Paraquat-Induced Cytotoxicity via SIRT1 in Non-Neuronal Cells by Attenuating the Depletion of NAD

Yu, Q., Wang, T., Zhou, X., Wu, J., Chen, X., Liu, Y., Wu, D., & Zhai, Q. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021770 · Cited by 12

Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders

Helman, T. J., & Braidy, N. (2022) · Drugs & Aging · doi:10.1007/s40266-022-00989-0 · Cited by 13

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Wang, J., Sun, R., Xia, L., Zhu, X., Zhang, Q., & Ye, Y. (2022) · Brain Sciences · doi:10.3390/brainsci12121699 · Cited by 14

Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins

Feng, S., Xie, N., Liu, Y., Qin, C., Savas, A. C., Wang, T., Li, S., Rao, Y., Shambayate, A., Chou, T., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01162-0 · Cited by 12

Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease

Ismaiel, A., Spînu, M., Budişan, L., Leucuta, D., Popa, S., Chiş, B. A., Berindan‐Neagoe, I., Olinic, D.-M., & Dumitrascu, D. L. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215194 · Cited by 12

Visfatin, Obesity, and Cancer

Dalamaga, Μ., & Christodoulatos, G. S. (2016) · Energy balance and cancer · doi:10.1007/978-3-319-41677-9_6 · Cited by 12

Visfatin concentrations in children with leukemia before and after stem cell transplantation

Skoczeń, S., Tomasik, P., Goździk, J., Fijorek, K., Krasowska-Kwiecień, A., Wiecha, O., Czogała, W., Dłużniewska, A., Sztefko, K., Starzyk, J., et al. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2013.12.006 · Cited by 12

Association of Nicotinamide Phosphoribosyltransferase (NAMPT) Gene Polymorphisms and of Serum NAMPT Levels with Dilated Cardiomyopathy in a Chinese Population

Dou, Q., Peng, Y., Zhou, B., Zhang, K., Lin, J., Dai, X., Zhang, L., & Rao, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160922299 · Cited by 12

Nutrient-Dependent Acetylation Controls Basic Regulatory Metabolic Switches and Cellular ReprogrammingPreprint

Dominy, J. E., Gerhart‐Hines, Z., & Puigserver, P. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2012.76.010843 · Cited by 12

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Gordon-Blake, J. M., Ratia, K. M., Weidig, V., Reddy, V. G., Ackerman-Berrier, M. S., Penton, C., Musku, S. R., Alves, E. T. M., Driver, T. G., Tai, L. M., et al. (2024) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.3c00391 · Cited by 11

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Xu, Y., Lu, A., Guan, X., Ying, T., Pan, J., Tan, M., & Lu, J. (2024) · Food Frontiers · doi:10.1002/fft2.511 · Cited by 11

MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866

Huang, P., Lee, M. W., Sadrerafi, K., Heruth, D. P., Zhang, L. Q., Maulik, D., & Ye, S. Q. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s125349 · Cited by 11

Circadian cardiac NAD+ metabolism, from transcriptional regulation to healthy aging

Carpenter, B. J., & Dierickx, P. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00239.2022 · Cited by 11

Nicotinamide phosphoribosyltransferase regulates cocaine reward through Sirtuin 1

Kong, J., Du, C., Jiang, L., Jiang, W., Deng, P., Shao, X., Zhang, B., Li, Y., Zhu, R., Zhao, Q., et al. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.05.010 · Cited by 12

FOXO1 functions in the regulation of nicotinamide phosphoribosyltransferase (Nampt) expression

Jeong, B., Park, J. W., Kim, J. G., & Lee, B. J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.069 · Cited by 11

Serum visfatin as a metabolic biomarker in obese patients with gestational diabetes mellitus

Radzicka, S., ZABOROWSKI, M. P., BRĄZERT, J., & PIETRYGA, M. (2022) · Minerva Endocrinology · doi:10.23736/s2724-6507.20.03280-0 · Cited by 11

NPC Natural Product Communications

Khana, S. I., Hester, J. P., Tekwania, B. L., Midiwob, J. O., Muhammada, I., Jaina, S. K., Jacoba, M. R., Walkera, L. A., Rahmana, A. A., & Samoylenkoa, V. (2011) · Cited by 11

Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

Zeidler, J. D., Chini, C. C. S., Kanamori, K. S., Kashyap, S., Espíndola‐Netto, J. M., Thompson, K. D., Warner, G. M., Cabral, F. S., Peclat, T., Gomez, L. S., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105431 · Cited by 11

Functional genomic screens with death rate analyses reveal mechanisms of drug action

Honeywell, M. E., Isidor, M. S., Harper, N. W., Fontana, R. E., Birdsall, G. A., Cruz‐Gordillo, P., Porto, S. A., Jerome, M., Fraser, C. S., Sarosiek, K. A., et al. (2024) · Nature Chemical Biology · doi:10.1038/s41589-024-01584-7 · Cited by 9

Harnessing lactic acid bacteria for nicotinamide mononucleotide biosynthesis: a review of strategies and future directions

Kong, L., Li, X., Liu, T., Yao, Q., & Qin, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1492179 · Cited by 10

NAD+ oscillation and hypothalamic neuronal functions

Tokizane, K., & Imai, S. (2021) · Faculty Reviews · doi:10.12703/r/10-42 · Cited by 10

Prediction of Cervical Cancer Outcome by Identifying and Validating a NAD+ Metabolism-Derived Gene Signature

Chen, A., Jing, W., Qiu, J., & Zhang, R. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12122031 · Cited by 10

The Effect of Ascorbic Acid and Nicotinamide on Panton–Valentine Leukocidin Cytotoxicity: An Ex Vivo Study

AlSaleh, A., Shahid, M., Farid, E., & Bindayna, K. M. (2023) · Toxins · doi:10.3390/toxins15010038 · Cited by 10

The Role of Adipokines in the Control of Pituitary Functions

Kamińska, B., Kurowicka, B., Kieżun, M., Dobrzyń, K., Kisielewska, K., Gudelska, M., Kopij, G., Szymańska, K., Zarzecka, B., Koker, O., et al. (2024) · Animals · doi:10.3390/ani14020353 · Cited by 10

Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors

Stein, L. R., Zorumski, C. F., Imai, S., & Izumi, Y. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.10.005 · Cited by 10

The Role of Visfatin in Pregnancy, Complications and Procreation

Marseglia, L. M., D’Angelo, G., Cuppari, C., Salpietro, V., Filippelli, M., Chirico, V., Gitto, E., Salpietro, C. D., Arrigo, T., & Manti, S. (2015) · Journal of Pediatric Biochemistry · doi:10.1055/s-0035-1554783 · Cited by 10

Sex-based differences in myocardial infarction-induced kidney damage following cigarette smoking exposure: more renal protection in premenopausal female mice

Habeichi, N. J., Mroueh, A., Kaplan, A., Ghali, R., Al-Awassi, H., Tannous, C., Husari, A. W., Jurjus, A. R., Altara, R., Booz, G. W., et al. (2020) · Bioscience Reports · doi:10.1042/bsr20193229 · Cited by 10

Structure-based virtual screening, molecular dynamics simulation and in vitro evaluation to identify inhibitors against NAMPT

Panwar, S., Kumari, A., Kumar, H., Tiwari, A. K., Tripathi, P., & Asthana, S. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1943526 · Cited by 10

Nicotinamide treatment reduces the levels of histone H3K4 trimethylation in the promoter of the mper1 circadian clock gene and blocks the ability of dexamethasone to induce the acute response

Xydous, M., Sekeri‐Pataryas, K. E., Prombona, A., & Sourlingas, T. G. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.03.001 · Cited by 10

Sirt1 as a key regulator orchestrating the response to caloric restriction

Moynihan, K. A., & Imai, S. (2006) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2006.02.005 · Cited by 10

Resveratrol treatment improves plasma and blood glucose concentration and lipid metabolism in high-fat-fed C57BL/6J mice

Yu, Y., Zhang, N., Jiang, H., Xue, W., Guo, X., Xu, X., Fang, W., Wang, H., & Hua, E. (2016) · European Food Research and Technology · doi:10.1007/s00217-016-2684-2 · Cited by 10

Adipose Tissues Have Been Overlooked as Players in Prostate Cancer Progression

Liermann-Wooldrik, K. T., Kosmacek, E. A., & Oberley‐Deegan, R. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212137 · Cited by 11

Circ_0008956 contributes to IL-1β-induced osteoarthritis progression via miR-149-5p/NAMPT axis

Fu, S., Fan, Q., Xu, J., Yu, S., Sun, M., Ji, Y., & Liu, D. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107857 · Cited by 9

NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction

Stock, A. J., & Liu, Y. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.785171 · Cited by 10

Untargeted Metabolomics Studies of H9c2 Cardiac Cells Submitted to Oxidative Stress, β-Adrenergic Stimulation and Doxorubicin Treatment: Investigation of Cardiac Biomarkers

Lima, M. F., Amaral, A. G., Moretto, I. A., Paiva-Silva, F. J. T. N., Pereira, F. O. B., Barbas, C., dos Santos, A. M., Simionato, A. V. C., & Rupérez, F. J. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.898742 · Cited by 9

Effects of dietary niacinamide and CP concentrations on the nitrogen excretion, growth performance, and meat quality of pigs

Wu, L., Tan, L. M., You, C. Y., Lan, T., Li, W. X., Xu, Y., Ren, Z., Ding, Q., Zhou, C., Tang, Z. R., et al. (2023) · animal · doi:10.1016/j.animal.2023.100869 · Cited by 9

Structural insights into Xanthomonas campestris pv. campestris NAD+ biosynthesis via the NAM salvage pathway

Xu, G., Ma, J., Fang, Q., Peng, Q., Jiao, X., Hu, W., Zhao, Q., Kong, Y., Liu, F., Shi, X., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-05921-3 · Cited by 8

Potential Therapeutic Interventions Targeting NAD+ Metabolism for ALS

Lundt, S., & Ding, S. (2024) · Cells · doi:10.3390/cells13171509 · Cited by 12

Pyridine Metabolism and Trigonelline Synthesis in Leaves of the Mangrove Legume trees Derris indica (Millettia pinnata ) and Caesalpinia crista

Yin, Y., Sasamoto, H., & Ashihara, H. (2011) · Natural Product Communications · doi:10.1177/1934578x1100601212 · Cited by 9

A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD+

Silveira, S. C., Buhagiar‐Labarchède, G., Onclercq, R., Gemble, S., Samra, E. B., Mameri, H., Duchambon, P., Machon, C., Guitton, J., & Amor-Guéret, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-70874-6 · Cited by 9

A Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, Suppresses the Growth of Anaplastic Meningiomas and Inhibits Immune Checkpoint Expression by Regulating STAT1

Deng, Y., Hu, B., Miao, Y., Wang, J., Zhang, S., Wan, H., Wu, Z., Lv, Y., Feng, J., Ji, N., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.836257 · Cited by 10

The Evolutionary Portrait of Metazoan NAD Salvage

Carneiro, J., Duarte-Pereira, S., Azevedo, L., Castro, L. F. C., Aguiar, P., Moreira, I. S., Amorim, A., & Silva, R. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064674 · Cited by 9

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Madawala, R. J., Banks, J. L., Hancock, S. E., Quek, L., Turner, N. A., & Wu, L. E. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108248 · Cited by 9

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Zhang, C.-Y., Zhu, X., Sun, W.-D., Bi, S.-Z., Lai, S.-Y., An-Liu, & Li, J.-H. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110558 · Cited by 8

Porcine placental extract increase the cellular NAD levels in human epidermal keratinocytes

Katayoshi, T., Yamaura, N., Nakajo, T., Kitajima, N., & Tsuji, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-23446-9 · Cited by 8

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Lundt, S., Zhang, N., Polo‐Parada, L., Wang, X., & Ding, S. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114698 · Cited by 9

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Henderson, D., Miranda, J. L., & Emerson, B. M. (2017) · Oncotarget · doi:10.18632/oncotarget.19841 · Cited by 8

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Shang, F., Chen, J., Wang, L., Jin, L., Zou, L., Bu, T., Dong, Y., Ha, N., Nam, K. H., Quan, C., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.08.067 · Cited by 8

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Biniecka, P., Matsumoto, S., Bellotti, A., Joussot, J., Bai, J., Majjigapu, S. R., Thoueille, P., Spaggiari, D., Desfontaine, V., Piacente, F., et al. (2023) · Molecules · doi:10.3390/molecules28041897 · Cited by 8

Formation of [Nicotinamide-2H3]NAD+ from [2H4]Nicotinamide and [2H4]Nicotinic Acid in Human HepG2N Cells and Involvement of 2H/1H Exchange at the Redox Site of NAD+/NADH

Hara, N., Shibata, T., Osago, H., Yamada, K., & Tsuchiya, M. (2014) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.60.17 · Cited by 8

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Seidel, M., King, J. A., Ritschel, F., Döpmann, J., Bühren, K., Seitz, J., Roessner, V., Westphal, S., Egberts, K. M., Burghardt, R., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.12.010 · Cited by 8

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Singh, R. K., van Haandel, L., Heruth, D. P., Ye, S. Q., Leeder, J. S., Becker, M. L., & Funk, R. S. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.246199 · Cited by 8

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Celichowski, P., Jopek, K., Milecka, P., Szyszka, M., Tyczewska, M., Malendowicz, L. K., & Ruciński, M. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8569 · Cited by 9

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Vora, M., Alattia, L., Ansari, J., ONG, M., Cotelingam, J. D., Coppola, D., & Shackelford, R. E. (2017) · Anticancer Research · doi:10.21873/anticanres.11889 · Cited by 8

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Zhang, W., Zhang, J., Xue, H., Chen, X., Li, M., Chen, S., Li, Z., Sechi, L. A., Wang, Q., Capobianco, G., et al. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400340 · Cited by 7

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Zhao, H., & Wu, W. (2025) · Antioxidants · doi:10.3390/antiox14101228 · Cited by 8

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Abdulsalam, E. A. A., & Harithy, R. N. A. (2021) · Annals of Medicine · doi:10.1080/07853890.2021.1925737 · Cited by 8

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Huang, W., Xu, J.-Z., & Zhang, W. (2023) · Systems Microbiology and Biomanufacturing · doi:10.1007/s43393-023-00172-5 · Cited by 7

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Guo, M., Song, Y., Cheng, J., Dong, G., Sun, X., & Sheng, C. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.109392 · Cited by 7

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Pugel, A. D., Schoenfeld, A. M., Alsaifi, S. Z., Holmes, J. R., & Morrison, B. E. (2024) · Pharmaceuticals · doi:10.3390/ph17020226 · Cited by 7

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Cardoso, D., Guilbert, S. M., Guigue, P., Carabalona, A., Harhouri, K., Peccate, C., Tournois, J., Guesmia, Z., Ferreira, L., Bartoli, C., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07078-7 · Cited by 8

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Sims, C. A., Labiner, H. E., Shah, S. S., & Baur, J. A. (2021) · GeroScience · doi:10.1007/s11357-020-00311-z · Cited by 7

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Nazari, M., Kordi, M. R., Minasian, V., & Quchan, A. H. S. K. (2022) · PubMed Central · doi:10.22038/ijbms.2022.65117.14335 · Cited by 7

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Almeida, K. H., Avalos-Irving, L., Berardinelli, S., Chauvin, K., & Yanez, S. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283428 · Cited by 7

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Furtado, A., Costa, D. R. B., Lemos, M. C., Cavaco, J. E. B., Santos, C. R. A., & Quintela, T. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.03.004 · Cited by 8

Synthesis of a C‐Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866

Gillig, A., Majjigapu, S. R., Sordat, B., & Vogel, P. (2012) · Helvetica Chimica Acta · doi:10.1002/hlca.201100415 · Cited by 7

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Heruth, D. P., Zhang, L. Q., & Ye, S. Q. (2011) · Journal of Bioanalysis & Biomedicine · doi:10.4172/1948-593x.1000047 · Cited by 6

Regulation of Nampt expression by transcriptional coactivator NCOA6 in pancreatic β-cells

Yoon, J. H., Lee, K. J., Oh, G., Kim, G. H., & Kim, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.098 · Cited by 7

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Eller, J., Stewart, M. L., Slepian, A. J., Markwardt, S., Wiedrick, J. T., Cohen, M. S., Goodman, R. H., & Cambronne, X. A. (2018) · Current Protocols in Cytometry · doi:10.1002/cpcy.54 · Cited by 7

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Marin-Blazquez, M., Rovira, J., Ramírez-Bajo, M. J., Perez, R. Z., & Rabadán-Ros, R. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01903-4 · Cited by 7

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Manickam, R., Santhana, S., Xuan, W., Bisht, K. S., & Tipparaju, S. M. (2025) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2024-0400 · Cited by 9

Oral nicotinamide mononucleotide (NMN) increases tissue NAD+ content in mice but neither NMN nor Polypodium leucotomos protect against UVR-induced skin cancer

Pihl, C., Kara, R., Granborg, J. R., Olesen, U. H., Bjerring, P., Hædersdal, M., Untracht, G. R., & Lerche, C. M. (2025) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-025-00736-5 · Cited by 7

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Kim, J. W., Manickam, R., Sinha, P., Xuan, W., Huang, J., Awad, K. R., Brotto, M. A. P., & Tipparaju, S. M. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31346 · Cited by 6

Soy food supplementation, dietary fat reduction and peripheral blood gene expression in postmenopausal women – A randomized, controlled trial

Wang, J., Siegmund, K. D., Tseng, C., Lee, A. S., & Wu, A. H. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100242 · Cited by 6

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Holay, N., Kennedy, B. E., Murphy, J. P., Konda, P., Giacomantonio, M., Brauer-Chapin, T., Paulo, J. A., Kumar, V., Kim, Y., Elaghil, M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1047661 · Cited by 6

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Cardoso, D., Barthélémy, I., Blot, S., & Muchir, A. (2023) · Skeletal Muscle · doi:10.1186/s13395-023-00328-w · Cited by 6

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Maylem, E. R. S., Schütz, L. F., & SPICER, L. J. (2024) · Reproduction Fertility and Development · doi:10.1071/rd24027 · Cited by 6

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Zeidan, M. A., Sharara, G. M., Suliman, H. S., Zeid, M., & Zytoun, S. S. (2012) · Cited by 6

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Wu, Z., Sun, Y., Huang, Y., Zhu, S., Feng, Y., Ye, H., Liu, C., & Tang, S. (2016) · Oncotarget · doi:10.18632/oncotarget.12864 · Cited by 6

Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors

Sadrerafi, K., Mason, E., & Lee, M. W. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s152685 · Cited by 6

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Rosti, V., Campanelli, R., Massa, M., Viarengo, G., Villani, L., Poletto, V., Bonetti, E., Catarsi, P., Magrini, U., Grolla, A. A., et al. (2016) · American Journal of Hematology · doi:10.1002/ajh.24388 · Cited by 6

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Hwang, E. S., & Hwang, S. Y. (2017) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.2017.21.4.149 · Cited by 6

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Welz, L., Harris, D. M. M., Kim, N., Alsaadi, A. I., Wu, Q., Oumari, M., Taubenheim, J., Volk, V., Credido, G., Koncina, E., et al. (2024) · medRxiv · doi:10.1101/2024.08.08.24311598 · Cited by 6

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Zheng, H., Wang, X., Gao, Z., Zhang, X., Liu, J., Yan, J., Li, N., Chen, R., Xu, Y., Yang, Y., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123706 · Cited by 5

MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma

Issa, L. H. B., Fléchon, L., Laine, W., Ouelkdite, A., Gaggero, S., Cozzani, A., Tilmont, R., Chauvet, P., Gower, N., Sklavenitis‐Pistofidis, R., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109417 · Cited by 5

Extracellular NAD+ response to post-hepatectomy liver failure: bridging preclinical and clinical findings

Kamali, C., Brunnbauer, P., Kamali, K., Saqr, A.-H. A., Arnold, A., Kamali, G. H., Babigian, J., Keshi, E., Mohr, R. U., Felsenstein, M., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06661-0 · Cited by 5

Outcomes of patients with post-hepatectomy hypophosphatemia: A narrative review

Chan, K. S., Mohan, S., & Shelat, V. G. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i8.1550 · Cited by 5

Capillary electrophoresis-mass spectrometry as a tool for Caenorhabditis elegans metabolomics research

Salzer, L., Schmitt‐Kopplin, P., & Witting, M. A. (2023) · Metabolomics · doi:10.1007/s11306-023-02025-7 · Cited by 5

Nicotinamide phosphoribose transferase facilitates macrophage-mediated pulmonary fibrosis through the Sirt1-Smad7 pathway in mice

Zhan, T., Chen, Y.-L., Dong, L., Wei, T.-F., Lu, D., Wang, Q., Wu, Z., Xu, J., & Ge, M. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176355 · Cited by 5

Effects of adding niacinamide to diets with normal and low protein levels on the immunity, antioxidant, and intestinal microbiota in growing-finishing pigs

Lan, T., Cai, M., Wang, S., Lü, Y., Tang, Z., Tang, Q., Gao, J., Xu, Y., Peng, X., & Sun, Z. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109809 · Cited by 5

Stability of nicotinamide - adenine dinucleotide phosphate and nicotinamide - adenine dinucleotide in tissue extracts under mildly acidic conditions

Neubert, D., Schulz, H.-U., & Hoehne, R. (1964) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(64)90023-9 · Cited by 9

The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals

Revollo, J. R., Grimm, A. A., & Imai, S. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32801b3c8f · Cited by 316

Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

Lin, S.-J., & Guarente, L. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00006-1 · Cited by 486

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Zhang, T., Berrocal, J. G., Frizzell, K. M., Gamble, M. J., DuMond, M. E., Krishnakumar, R., Yang, T., Sauve, A. A., & Kraus, W. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016469 · Cited by 234

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