Imai, Shin-ichiro

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature

Genomics and Chromatin DynamicsSirtuins and Resveratrol in Medicine

Cited by 3,510

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell

Sirtuins and Resveratrol in MedicineCancer-related Molecular Pathways

Cited by 2,081

NAD+ and sirtuins in aging and disease

Imai, S.-I., & Guarente, L. (2014) · Trends in Cell Biology

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 1,481

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism

Sirtuins and Resveratrol in MedicineMetabolism, Diabetes, and Cancer

Cited by 1,340

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis

Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science

Circadian rhythm and melatoninSirtuins and Resveratrol in Medicine

Cited by 1,126

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

Yoshino, J., Baur, J. A., & Imai, S.-I. (2018) · Cell Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 1,061

The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

Revollo, J. R., Grimm, A. A., & Imai, S.-I. (2004) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 1,010

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., et al. (2016) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 930

Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

Revollo, J. R., Körner, A., Mills, K. F., Satoh, A., Wang, T., Garten, A., Dasgupta, B., Sasaki, Y., Wolberger, C., Townsend, R. R., et al. (2007) · Cell Metabolism

Sirtuins and Resveratrol in MedicinePancreatic function and diabetes

Cited by 911

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S.-I., et al. (2021) · Science

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 439

Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice

Yoshida, M., Satoh, A., Lin, J. B., Mills, K. F., Sasaki, Y., Rensing, N., Wong, M., Apte, R. S., & Imai, S.-I. (2019) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 407

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell

Sirtuins and Resveratrol in MedicineCardiovascular Health and Disease Prevention

Cited by 396

It takes two to tango: NAD(+) and sirtuins in aging/longevity control

Imai, S.-I., & Guarente, L. (2016) · npj Aging and Mechanisms of Disease

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 394

Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice

Ramsey, K. M., Mills, K. F., Satoh, A., & Imai, S. (2008) · Aging Cell

Sirtuins and Resveratrol in MedicinePancreatic function and diabetes

Cited by 321

Slc12a8 is a nicotinamide mononucleotide transporter

Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E., et al. (2019) · Nature Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 287

Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

Stein, L. R., & Imai, S. (2014) · The EMBO Journal

Neurogenesis and neuroplasticity mechanismsSirtuins and Resveratrol in Medicine

Cited by 265

SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus

Satoh, A., Brace, C. S., Ben-Josef, G., West, T., Wozniak, D. F., Holtzman, D. M., Herzog, E. D., & Imai, S.-I. (2010) · The Journal of Neuroscience

Sirtuins and Resveratrol in MedicineRegulation of Appetite and Obesity

Cited by 237

NAMPT-Mediated NAD+ Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice

Stromsdorfer, K. L., Yamaguchi, S., Yoon, M. J., Moseley, A. C., Franczyk, M. P., Kelly, S. C., Qi, N., Imai, S.-I., & Yoshino, J. (2016) · Cell Reports

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 213

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., et al. (2020) · Endocrine Journal

Sirtuins and Resveratrol in MedicineFolate and B Vitamins Research

Cited by 191

NAD+ biosynthesis, aging, and disease

Johnson, S., & Imai, S. (2018) · F1000Research

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 178

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Editorial

Imai, S., & Kitano, H. (1998) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 82

Dietary restriction: standing up for sirtuins

Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., Cabo, R. D., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., et al. (2010) · Science

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 76

Diurnal Variation in Insulin Sensitivity of Glucose Metabolism Is Associated With Diurnal Variations in Whole-Body and Cellular Fatty Acid Metabolism in Metabolically Normal Women

Yoshino, J., Almeda-Valdes, P., Patterson, B. W., Okunade, A. L., Imai, S.-I., Mittendorfer, B., & Klein, S. (2014) · The Journal of Clinical Endocrinology & Metabolism

Circadian rhythm and melatoninAdipose Tissue and Metabolism

Cited by 75