The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer
Open accessAbstract
Prostaglandin E2 (PGE2) can stimulate tumor progression by modulating several proneoplastic pathways, including proliferation, angiogenesis, cell migration, invasion, and apoptosis. Although steady-state tissue levels of PGE2 stem from relative rates of biosynthesis and breakdown, most reports examining PGE2 have focused solely on the cyclooxygenase-dependent formation of this bioactive lipid. Enzymatic degradation of PGE2 involves the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). The present study examined a range of normal tissues in the human and mouse and found high levels of 15-PGDH in the large intestine. By contrast, the expression of 15-PGDH is decreased in several colorectal carcinoma cell lines and in other human malignancies such as breast and lung carcinomas. Consistent with these findings, we observe diminished 15-Pgdh expression in ApcMin+/- mouse adenomas. Enzymatic activity of 15-PGDH correlates with expression levels and the genetic disruption of 15-Pgdh completely blocks production of the urinary PGE2 metabolite. Finally, 15-PGDH expression and activity are significantly down-regulated in human colorectal carcinomas relative to matched normal tissue. In summary, these results suggest a novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression.
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Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice
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Cited by
Molecular Basis of Colorectal Cancer
Markowitz, S. D., & Bertagnolli, M. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804588 · Cited by 2,052
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The role of COX‐2 in intestinal inflammation and colorectal cancer
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Self-citationInflammation: Gearing the journey to cancer
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Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer
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Metadata
- Authors
- Backlund, M. G., Mann, J. R., Holla, V. R., Buchanan, F. G., Tai, H.-H., Musiek, E. S., Milne, G. L., Katkuri, S., & DuBois, R. N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 280
- Issue
- 5
- Pages
- 3217-3223
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2014306540
- Cited by
- 301
- References
- 32
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: 15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer. https://app.cochat.ai/papers/10.1074/jbc.m411221200
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- Backlund, M. G., Mann, J. R., Holla, V. R., Buchanan, F. G., Tai, H.-H., Musiek, E. S., Milne, G. L., Katkuri, S., & DuBois, R. N. (2005). 15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m411221200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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