The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Heme-regulated Inhibitor Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival upon Arsenite Exposure
Open accessAbstract
Exposure to arsenite inhibits protein synthesis and activates multiple stress signaling pathways. Although arsenite has diverse effects on cell metabolism, we demonstrated that phosphorylation of eukaryotic translation initiation factor 2 at Ser-51 on the alpha subunit was necessary to inhibit protein synthesis initiation in arsenite-treated cells and was essential for stress granule formation. Of the four protein kinases known to phosphorylate eukaryotic translation initiation factor 2alpha, only the heme-regulated inhibitor kinase (HRI) was required for the translational inhibition in response to arsenite treatment in mouse embryonic fibroblasts. In addition, HRI expression was required for stress granule formation and cellular survival after arsenite treatment. In vivo studies elucidated a fundamental requirement for HRI in murine survival upon acute arsenite exposure. The results demonstrated an essential role for HRI in mediating arsenite stress-induced phosphorylation of eukaryotic translation initiation factor 2alpha, inhibition of protein synthesis, stress granule formation, and survival.
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Cites
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
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Translational control of gene expression
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Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
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Self-citationTranslational control of gene expression
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Dynamic Shuttling of Tia-1 Accompanies the Recruitment of mRNA to Mammalian Stress Granules
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The integrated stress response
Pakos‐Zebrucka, K., Koryga, I., Mnich, K., Ljujic, M., Samali, A., & Gorman, A. M. (2016) · The EMBO Reports · doi:10.15252/embr.201642195 · Cited by 2,659
Stress granules: the Tao of RNA triage
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Self-citationAnderson, P., & Kedersha, N. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512082 · Cited by 984
Self-citationAngiogenin cleaves tRNA and promotes stress-induced translational repression
Yamasaki, S., Ivanov, P., Hu, G.-F., & Anderson, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200811106 · Cited by 936
Self-citationStress granules and neurodegeneration
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Metadata
- Authors
- McEwen, E., Kedersha, N., Song, B., Scheuner, D., Gilks, N., Han, A., Chen, J.-J., Anderson, P., & Kaufman, R. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 280
- Issue
- 17
- Pages
- 16925-16933
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2040640278
- Cited by
- 447
- References
- 43
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- McEwen, E., Kedersha, N., Song, B., Scheuner, D., Gilks, N., Han, A., Chen, J.-J., Anderson, P., & Kaufman, R. J. (2005). Heme-regulated Inhibitor Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival upon Arsenite Exposure. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m412882200
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