The integrated stress response

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

Autophagy and the Integrated Stress Response

Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336 · see citing works

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Harding, H. P., Zhang, Y., & Ron, D. (1999) · Nature · doi:10.1038/16729 · Cited by 3,310 · see citing works

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R. C., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,281 · see citing works

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

Bertolotti, A., Zhang, Y., Hendershot, L. M., Harding, H. P., & Ron, D. (2000) · Nature Cell Biology · doi:10.1038/35014014 · Cited by 2,871 · see citing works

The mechanism of eukaryotic translation initiation and principles of its regulation

Jackson, R. J., Hellen, C. U. T., & Pestova, T. V. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2838 · Cited by 2,759 · see citing works

Mediators of endoplasmic reticulum stress-induced apoptosis

Szegezdi, E., Logue, S. E., Gorman, A. M., & Samali, A. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400779 · Cited by 2,345 · see citing works

Perk is essential for translational regulation and cell survival during the unfolded protein response

Harding, H. P., Zhang, Y., Bertolotti, A., Zeng, H., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80330-5 · Cited by 2,021 · see citing works

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumPreprint

Marciniak, S. J., Yun, C. Y., Oyadomari, S., Novoa, I., Zhang, Y., Jungreis, R., Nagata, K., Harding, H. P., & Ron, D. (2004) · Genes & Development · doi:10.1101/gad.1250704 · Cited by 2,004 · see citing works

X-linked IAP is a direct inhibitor of cell-death proteases

Deveraux, Q. L., Takahashi, R., Salvesen, G. S., & Reed, J. C. (1997) · Nature · doi:10.1038/40901 · Cited by 1,956 · see citing works

IAP proteins: blocking the road to death's door

Salvesen, G. S., & Duckett, C. S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm830 · Cited by 1,756 · see citing works

Reinitiation involving upstream ORFs regulates <i>ATF4</i> mRNA translation in mammalian cells

Vattem, K. M., & Wek, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400541101 · Cited by 1,696 · see citing works

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

Han, J., Back, S. H., Hur, J., Lin, Y.-H., Gildersleeve, R., Shan, J., Yuan, C. L., Krokowski, D., Wang, S., Hatzoglou, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2738 · Cited by 1,691 · see citing works

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

Wang, M., & Kaufman, R. J. (2016) · Nature · doi:10.1038/nature17041 · Cited by 1,630 · see citing works

The Biology of Proteostasis in Aging and Disease

Labbadia, J., & Morimoto, R. I. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033955 · Cited by 1,472 · see citing works

ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

Puthalakath, H., O’Reilly, L. A., Gunn, P. A., Lee, L., Kelly, P. N., Huntington, N. D., Hughes, P., Michalak, E. M., McKimm‐Breschkin, J. L., Motoyama, N., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.027 · Cited by 1,428 · see citing works

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

Boyce, M., Bryant, K. F., Jousse, C., Long, K., Harding, H. P., Scheuner, D. L., Kaufman, R. J., Ma, D., Coen, D. M., Ron, D., et al. (2005) · Science · doi:10.1126/science.1101902 · Cited by 1,403 · see citing works

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

Novoa, I., Zeng, H., Harding, H. P., & Ron, D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.1011 · Cited by 1,392 · see citing works

IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

Lin, J. H., Li, H., Yasumura, D., Cohen, H. R., Zhang, C., Panning, B., Shokat, K. M., LaVail, M. M., & Walter, P. (2007) · Science · doi:10.1126/science.1146361 · Cited by 1,374 · see citing works

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

Scheuner, D. L., Song, B., McEwen, E. L., Liu, C., Laybutt, D. R., Gillespie, P. J., Saunders, T. L., Bonner‐Weir, S., & Kaufman, R. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00265-9 · Cited by 1,355 · see citing works

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

Hai, T., & Curran, T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3720 · Cited by 1,321 · see citing works

Leptin regulation of bone resorption by the sympathetic nervous system and CART

Elefteriou, F., Ahn, J. D., Takeda, S., Starbuck, M., Yang, X., Liu, X., Kondo, H., Richards, W. G., Bannon, T. W., Noda, M., et al. (2005) · Nature · doi:10.1038/nature03398 · Cited by 1,311 · cited 2× · see citing works

Coping with stress: eIF2 kinases and translational control

Wek, R. C., Jiang, H.-Y., & Anthony, T. G. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340007 · Cited by 1,290 · see citing works

TRANSLATIONAL REGULATION OFGCN4AND THE GENERAL AMINO ACID CONTROL OF YEAST

Hinnebusch, A. G. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.031805.133833 · Cited by 1,258 · see citing works

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

B’chir, W., Maurin, A.-C., Carraro, V., Averous, J., Jousse, C., Muranishi, Y., Parry, L., Stepien, G., Fafournoux, P., & Bruhat, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt563 · Cited by 1,162 · see citing works

miRiad Roles for the miR-17-92 Cluster in Development and Disease

Mendell, J. T. (2008) · Cell · doi:10.1016/j.cell.2008.04.001 · Cited by 1,086 · see citing works

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

MEURS, E. F., Chong, K. L., GALABRU, J., Thomas, N. S. B., Kerr, I. M., Williams, B. R. G., & Hovanessian, A. G. (1990) · Cell · doi:10.1016/0092-8674(90)90374-n · Cited by 1,017 · see citing works

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

Lu, P. D., Harding, H. P., & Ron, D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408003 · Cited by 1,006 · see citing works

TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death

Ohoka, N., Yoshii, S., Hattori, T., Onozaki, K., & Hayashi, H. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600596 · Cited by 1,004 · see citing works

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R. J., Kominami, E., & Momoi, T. (2007) · Cell Death &amp; Differentiation · doi:10.1038/sj.cdd.4401984 · Cited by 934 · see citing works

The eIF2α kinases: their structures and functions

Donnelly, N., Gorman, A. M., Gupta, S., & Afshin Samali, A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1252-6 · Cited by 860 · see citing works

TRB3: A <i>tribbles</i> Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

Du, K., Herzig, S., Kulkarni, R. N., & Montminy, M. (2003) · Science · doi:10.1126/science.1079817 · Cited by 842 · see citing works

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40027 · Cited by 829 · see citing works

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone‐Corsi, P., Townes, T. M., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00344-7 · Cited by 822 · see citing works

PKR; a sentinel kinase for cellular stress

Williams, B. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203127 · Cited by 820 · see citing works

Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action

García, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., & Esteban, M. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00027-06 · Cited by 818 · see citing works

EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

Delépine, M., Nicolino, M., Barrett, T., Golamaully, M., Mark Lathrop, G., & Julier, C. (2000) · Nature Genetics · doi:10.1038/78085 · Cited by 813 · see citing works

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

Rutkowski, D. T., Arnold, S. M., Miller, C. N., Wu, J., Li, J., Gunnison, K. M., Mori, K., Akha, A. A. S., Raden, D. L., & Kaufman, R. J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040374 · Cited by 804 · see citing works

Translational control in the endoplasmic reticulum stress response

Ron, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16784 · Cited by 778 · see citing works

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

Dever, T. E., Feng, L., Wek, R. C., Cigan, A. M., Donahue, T. F., & Hinnebusch, A. G. (1992) · Cell · doi:10.1016/0092-8674(92)90193-g · Cited by 776 · see citing works

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

Shi, Y., Vattem, K. M., Sood, R., An, J., Liang, J., Stramm, L. E., & Wek, R. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7499 · Cited by 776 · see citing works

Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

Tallóczy, Z., Jiang, W., Virgin, H. W., Leib, D. A., Scheuner, D. L., Kaufman, R. J., Eskelinen, E., & Levine, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012485299 · Cited by 741 · see citing works

Pharmacological brake-release of mRNA translation enhances cognitive memory

Sidrauski, C., Acosta‐Alvear, D., Khoutorsky, A., Vedantham, P., Hearn, B. R., Li, H., Gamache, K., Gallagher, C. M., Ang, K. K. H., Wilson, C. G. M., et al. (2013) · eLife · doi:10.7554/elife.00498 · Cited by 732 · see citing works

ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

Bi, M., Naczki, C., Koritzinsky, M., Fels, D. R., Blais, J. D., Hu, N., Harding, H. P., Novoa, I., Varia, M. A., Raleigh, J. A., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600777 · Cited by 732 · see citing works

Translational control in the endoplasmic reticulum stress response

Ron, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216784 · Cited by 728 · see citing works

Initiation of Protein Synthesis in Eukaryotic Cells

Pain, V. M. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00747.x · Cited by 712 · see citing works

The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

Ye, J., Kumanova, M., Hart, L. S., Sloane, K. L., Zhang, H., Panis, D. N. D., Bobrovnikova-Marjon, E. V., Diehl, J. A., Ron, D., & Koumenis, C. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.81 · Cited by 709 · see citing works

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

Gardner, B. M., & Walter, P. (2011) · Science · doi:10.1126/science.1209126 · Cited by 689 · see citing works

Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2

Deng, J., Lu, P. D., Zhang, Y., Scheuner, D. L., Kaufman, R. J., Sonenberg, N., Harding, H. P., & Ron, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10161-10168.2004 · Cited by 645 · see citing works

The dsRNA protein kinase PKR: Virus and cell control

García, M. A., Meurs, E. F., & Esteban, M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.03.001 · Cited by 644 · see citing works

Multiple upstream AUG codons mediate translational control of GCN4

Mueller, P. P., & Hinnebusch, A. G. (1986) · Cell · doi:10.1016/0092-8674(86)90384-3 · Cited by 641 · see citing works

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1 H -indol-5-yl)-7 H -pyrrolo[2,3- d ]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Axten, J. M., Medina, J. R., Feng, Y., Shu, A. Y. L., Romeril, S. P., Grant, S. W., Li, W. H. H., Heerding, D. A., Minthorn, E. A., Mencken, T., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300713s · Cited by 620 · see citing works

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

Sidrauski, C., McGeachy, A. M., Ingolia, N. T., & Walter, P. (2015) · eLife · doi:10.7554/elife.05033 · Cited by 616 · see citing works

The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

Clemens, M. J., & Elia, A. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.503 · Cited by 605 · see citing works

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

Oyadomari, S., Takeda, K., Takiguchi, M., Gotoh, T., Matsumoto, M., Wada, I., Akira, S., Araki, E., & Mori, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191207498 · Cited by 599 · see citing works

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

Puri, P., Mirshahi, F., Cheung, O., Natarajan, R., Maher, J. W., Kellum, J. M., & Sanyal, A. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.039 · Cited by 596 · see citing works

ATF4-dependent transcription mediates signaling of amino acid limitation

Kilberg, M. S., Shan, J., & Su, N. Y. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.05.008 · Cited by 595 · see citing works

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R. (1995) · Cell · doi:10.1016/0092-8674(95)90213-9 · Cited by 572 · see citing works

The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4

Sayer, J. A., Otto, E. A., O’Toole, J. F., Nürnberg, G., Kennedy, M. A., Becker, C., Hennies, H. C., Helou, J., Attanasio, M., Fausett, B. V., et al. (2006) · Nature Genetics · doi:10.1038/ng1786 · Cited by 571 · see citing works

Activating transcription factor 4

Ameri, K., & Harris, A. L. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.020 · Cited by 557 · see citing works

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

Tsaytler, P. A., Harding, H. P., Ron, D., & Bertolotti, A. (2011) · Science · doi:10.1126/science.1201396 · Cited by 536 · see citing works

Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection

Balachandran, S., Roberts, P. C., Brown, L. E., Truong, H., Pattnaik, A. K., Archer, D. R., & Barber, G. N. (2000) · Immunity · doi:10.1016/s1074-7613(00)00014-5 · Cited by 527 · see citing works

Translational Regulation of Yeast GCN4

Hinnebusch, A. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.21661 · Cited by 526 · see citing works

SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation

Dobreva, G. D., Chahrour, M. H., Dautzenberg, M., Chirivella, L., Kanzler, B., Fariñas, I., Karsenty, G., & Grosschedl, R. (2006) · Cell · doi:10.1016/j.cell.2006.05.012 · Cited by 522 · see citing works

Coping with stress: eIF2 kinases and translational control

Jiang, H.-Y., Wek, R. C., & Anthony, T. G. (2005) · Biochemical Society Transactions · doi:10.1042/bst20060007 · Cited by 522 · see citing works

The Mechanism of Eukaryotic Translation Initiation: New Insights and ChallengesPreprint

Hinnebusch, A. G., & Lorsch, J. R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011544 · Cited by 506 · see citing works

Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response

Jiang, H.-Y., Wek, S. A., McGrath, B. C., Lü, D., Hai, T., Harding, H. P., Wang, X., Ron, D., Cavener, D. R., & Wek, R. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.1365-1377.2004 · Cited by 504 · see citing works

Stress‐induced gene expression requires programmed recovery from translational repression

Novoa, I., Zhang, Y., Zeng, H., Jungreis, R., Harding, H. P., & Ron, D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg112 · Cited by 474 · see citing works

Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein

He, C. H., Gong, P., Hu, B., Stewart, D., Choi, M. E., Choi, A. M. K., & Alam, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101198200 · Cited by 473 · see citing works

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)‒ATF composite site to regulate Gadd153 expression during the stress response

Fawcett, T. W., Martindale, J. L., Guyton, K. Z., Hai, T., & Holbrook, N. J. (1999) · Biochemical Journal · doi:10.1042/bj3390135 · Cited by 472 · see citing works

Delineation of a Negative Feedback Regulatory Loop That Controls Protein Translation during Endoplasmic Reticulum Stress

Ma, Y., & Hendershot, L. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301107200 · Cited by 458 · see citing works

Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes

Hinnebusch, A. G. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00008-11 · Cited by 451 · see citing works

Heme-regulated Inhibitor Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival upon Arsenite Exposure

McEwen, E. L., Kedersha, N., Song, B., Scheuner, D. L., Gilks, N., Han, A., Chen, J.-J., Anderson, P., & Kaufman, R. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412882200 · Cited by 448 · see citing works

Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress

Blais, J. D., Filippenko, V., Bi, M., Harding, H. P., Ron, D., Koumenis, C., Wouters, B. G., & Bell, J. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7469-7482.2004 · Cited by 447 · see citing works

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

Atkins, C., Liu, Q., Minthorn, E., Zhang, S.-Y., Figueroa, D. J., Moss, K., Stanley, T. B., Sanders, B., Goetz, A., Gaul, N., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3109 · Cited by 443 · see citing works

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation

Palam, L. R., Baird, T. D., & Wek, R. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.216093 · Cited by 441 · see citing works

The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

Zhang, P., McGrath, B. C., Reinert, J., Olsen, D. S., Li, L., Gill, S., Wek, S. A., Vattem, K. M., Wek, R. C., Kimball, S. R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.19.6681-6688.2002 · Cited by 439 · see citing works

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

Hart, L. S., Cunningham, J. T., Datta, T., Dey, S., Tameire, F., Lehman, S. L., Qiu, B., Zhang, H., Cerniglia, G. J., Bi, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62973 · Cited by 436 · see citing works

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

Das, I., Krzyżosiak, A., Schneider, K., Wrabetz, L. G., D’Antonio, M., Barry, N. P., Sigurdardottir, A., & Bertolotti, A. (2015) · Science · doi:10.1126/science.aaa4484 · Cited by 436 · see citing works

Halofuginone Inhibits T H 17 Cell Differentiation by Activating the Amino Acid Starvation Response

Sundrud, M. S., Koralov, S. B., Feuerer, M., Calado, D. P., Kozhaya, A. E., Rhule-Smith, A., Lefebvre, R. E., Unutmaz, D., Mazitschek, R., Waldner, H., et al. (2009) · Science · doi:10.1126/science.1172638 · Cited by 422 · see citing works

Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum

Liu, C. Y., Schröder, M., & Kaufman, R. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004454200 · Cited by 421 · see citing works

Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2

Costa-Mattioli, M., Gobert, D., Harding, H., Herdy, B., Azzi, M., Bruno, M., Bidinosti, M., Mamou, C. B., Marcinkiewicz, E., Yoshida, M., et al. (2005) · Nature · doi:10.1038/nature03897 · Cited by 421 · see citing works

A mechanistic overview of translation initiation in eukaryotes

Aitken, C. E., & Lorsch, J. R. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2303 · Cited by 419 · see citing works

Heme‐regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

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Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

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ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

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Search for new genes involved in the integrated stress response

Гараева, А. Л., Kovaleva, I. E., & Evstafieva, A. G. (2015) · FEBS Journal