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Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation
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“Increasing K6-linked auto-ubiquitination (i.e. by silencing USP8) is likely to stabilize parkin by protecting it from degradation in the proteasome or lysosome”
From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Shang et al, 2005
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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
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Cited by
Sorted by citations
USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin
Durcan, T. M., Tang, M. Y., Pérusse, J. R., Dashti, E. A., Aguileta, M. A., McLelland, G., Gros, P., Shaler, T. A., Faubert, D., Coulombe, B., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201489729 · Cited by 375
Cripps, D., Thomas, S. N., Jeng, Y., Yang, F., Davies, P., & Yang, A. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512786200 · Cited by 312
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics
Kirkpatrick, D. S., Denison, C., & Gygi, S. P. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-750 · Cited by 209
Uchiki, T., Weikel, K. A., Jiao, W., Shang, F., Caceres, A., Pawlak, D., Handa, J. T., Brownlee, M., Nagaraj, R., & Taylor, A. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2011.00752.x · Cited by 200
“S9B) (Shang et al., 2005).”
BackgroundSelf-citationAging and regulated protein degradation: who has the UPPer hand?
Vernace, V. A., Schmidt‐Glenewinkel, T., & Figueiredo‐Pereira, M. E. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00329.x · Cited by 110
Metadata
- Authors
- Shang, F., Deng, G., Liu, Q., Guo, W., Haas, A. L., Crosas, B., Finley, D., & Taylor, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 280
- Issue
- 21
- Pages
- 20365-20374
- ISSN
- 0021-9258
- Cited by
- 74
- References
- 1
- Language
- en
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- CoChat. (2026). Citation check: Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation. https://app.cochat.ai/papers/10.1074/jbc.m414356200
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- Shang, F., Deng, G., Liu, Q., Guo, W., Haas, A. L., Crosas, B., Finley, D., & Taylor, A. (2005). Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m414356200