The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
c-FLIPR, a New Regulator of Death Receptor-induced Apoptosis
Open accessAbstract
c-FLIPs (c-FLICE inhibitory proteins) play an essential role in regulation of death receptor-induced apoptosis. Multiple splice variants of c-FLIP have been described on the mRNA level; so far only two of them, c-FLIP(L) and c-FLIP(S,) had been found to be expressed at the protein level. In this report, we reveal the endogenous expression of a third isoform of c-FLIP. We demonstrate its presence in a number of T and B cell lines as well as in primary human T cells. We identified this isoform as c-FLIP(R), a death effector domain-only splice variant previously identified on the mRNA level. Impor-/tantly, c-FLIP(R) is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex upon CD95 stimulation. Several properties of c-FLIP(R) are similar to c-FLIP(S): both isoforms have a short half-life, a similar pattern of expression during activation of primary human T cells, and are strongly induced in T cells upon CD3/CD28 costimulation. Taken together, our data demonstrate endogenous expression of c-FLIP(R) and similar roles of c-FLIP(R) and c-FLIP(S) isoforms in death receptor-mediated apoptosis.
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Cites
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Brenner, D., Blaser, H., & Mak, T. W. (2015) · Nature Reviews Immunology · doi:10.1038/nri3834 · Cited by 998
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Falschlehner, C., Emmerich, C. H., Gerlach, B., & Walczak, H. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.02.007 · Cited by 458
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Metadata
- Authors
- Golks, A., Brenner, D., Fritsch, C., Krammer, P. H., & Lavrik, I. N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 280
- Issue
- 15
- Pages
- 14507-14513
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1997759940
- Cited by
- 282
- References
- 33
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Golks, A., Brenner, D., Fritsch, C., Krammer, P. H., & Lavrik, I. N. (2005). c-FLIPR, a New Regulator of Death Receptor-induced Apoptosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m414425200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
