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Wallace, K., Burt, A. D., & Wright, M. C. (2008) · Biochemical Journal · doi:10.1042/bj20071570 · Cited by 273 · see citing works

MAPK signaling in inflammation-associated cancer development

Huang, P., Han, J., & Hui, L. (2010) · Protein &amp; Cell · doi:10.1007/s13238-010-0019-9 · Cited by 273 · see citing works

c-FLIP, a master anti-apoptotic regulator.

Safa, A. R. (2012) · PubMed · Cited by 272 · see citing works

Role of Oxidative Stress in Pancreatic Inflammation

Leung, P. S., & Chan, Y. C. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2109 · Cited by 264 · see citing works

Tumor Promotion via Injury- and Death-Induced Inflammation

Kuraishy, A. I., Karin, M., & Grivennikov, S. I. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.006 · Cited by 265 · see citing works

Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies

Broekgaarden, M., Weijer, R., van Gulik, T. M., Hamblin, M. R., & Heger, M. (2015) · Cancer and Metastasis Reviews · doi:10.1007/s10555-015-9588-7 · Cited by 261 · see citing works

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

Nakagawa, H., Maeda, S., Hikiba, Y., Ohmae, T., Shibata, W., Yanai, A., Sakamoto, K., Ogura, K., Noguchi, T., Karin, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.006 · Cited by 253 · see citing works

Leptin, IL‐10 and Inflammatory Markers (TNF‐α, IL‐6 and IL‐8) in Pre‐Eclamptic, Normotensive Pregnant and Healthy Non‐Pregnant Women

Sharma, A., Satyam, A., & Sharma, J. B. (2007) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2007.00486.x · Cited by 247 · see citing works

Apoptosis signaling pathways and lymphocyte homeostasis

Xu, G., & Shi, Y. (2007) · Cell Research · doi:10.1038/cr.2007.52 · Cited by 243 · see citing works

p62, an autophagy hero or culprit?

Rusten, T. E., & Stenmark, H. (2010) · Nature Cell Biology · doi:10.1038/ncb0310-207 · Cited by 237 · see citing works

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Demarco, B., Grayczyk, J. P., Bjånes, E., Roy, D. L., Tonnus, W., Assenmacher, C., Radaelli, E., Fettrelet, T., Mack, V., Linkermann, A., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc3465 · Cited by 237 · see citing works

Ral GTPases and cancer: linchpin support of the tumorigenic platform

Bodemann, B. O., & White, M. A. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2296 · Cited by 231 · see citing works

The Nedd4-like family of E3 ubiquitin ligases and cancer

Chen, C., & Matesic, L. E. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9091-x · Cited by 228 · see citing works

The E3 ubiquitin ligase Itch controls the protein stability of p63

Rossi, M., Aqeilan, R. I., Neale, M. H., Candi, E., Salomoni, P., Knight, R. A., Croce, C. M., & Melino, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603449103 · Cited by 220 · see citing works

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells

Trivedi, R., & Mishra, D. P. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00069 · Cited by 223 · see citing works

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

Wang, P., Ji, Y., Zhang, X., Zhao, L., Yan, Z.-Z., Zhang, P., Shen, L., Yang, X., Fang, J., Tian, S., et al. (2017) · Nature Medicine · doi:10.1038/nm.4290 · Cited by 221 · see citing works

Hepatic Tumor Necrosis Factor Signaling and Nuclear Factor-κB: Effects on Liver Homeostasis and Beyond

Wullaert, A., Loo, G., Heyninck, K., & Beyaert, R. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0031 · Cited by 217 · see citing works

Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity

Malhi, H., Barreyro, F. J., Isomoto, H., Bronk, S. F., & Gores, G. J. (2007) · Gut · doi:10.1136/gut.2006.118059 · Cited by 212 · see citing works

Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): A critical discussion

Ingawale, D. K., Mandlik, S. K., & Suresh Ramnath, N. A. I. K. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.08.015 · Cited by 202 · see citing works

Cell Survival through Trk Neurotrophin Receptors Is Differentially Regulated by Ubiquitination

Arévalo, J. C., Waite, J. C., Rajagopal, R., Beyna, M., Chen, Z.-Y., Lee, F. S., & Chao, M. V. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.044 · Cited by 202 · see citing works

Redox Control of Liver Function in Health and Disease

Marı́, M., Colell, A., Morales, A., von Montfort, C., García‐Ruiz, C., & Fernández-Checa, J. C. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2634 · Cited by 201 · see citing works

Mechanisms of crosstalk between TNF-induced NF-κB and JNK activation in hepatocytes

Wullaert, A., Heyninck, K., & Beyaert, R. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.003 · Cited by 200 · see citing works

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice

Win, S., Than, T. A., Han, D., Petrovic, L. M., & Kaplowitz, N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276089 · Cited by 197 · see citing works

Reactive Oxygen Species in TNFα-Induced Signaling and Cell Death

Morgan, M. J., & Liu, Z.-G. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0105-0 · Cited by 198 · see citing works

Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

Pan, Y., Wang, Y. N., Zhao, Y., Peng, K., Li, W., Wang, Y., Zhang, J., Zhou, S., Liu, Q., Li, X., et al. (2014) · Diabetes · doi:10.2337/db13-1577 · Cited by 195 · see citing works

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

Kodama, Y., Kisseleva, T., Iwaisako, K., Miura, K., Taura, K., Minicis, S. D., Österreicher, C. H., Schnabl, B., Seki, E., & Brenner, D. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.045 · Cited by 195 · see citing works

The isoform‐specific functions of the c‐Jun N‐terminal Kinases (JNKs): differences revealed by gene targeting

Bogoyevitch, M. A. (2006) · BioEssays · doi:10.1002/bies.20458 · Cited by 190 · see citing works

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

Sampson, C., Wang, Q., Otkur, W., Zhao, H., Lu, Y., Liu, X., & Piao, H. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1204 · Cited by 186 · see citing works

Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy

Safa, A. R., Day, T. W., & Wu, C. (2008) · Current Cancer Drug Targets · doi:10.2174/156800908783497087 · Cited by 183 · see citing works

Tumor necrosis factor-α: regulation of renal function and blood pressure

Ramseyer, V. D., & Garvin, J. L. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00557.2012 · Cited by 184 · see citing works

Mitogen-activated protein kinases in hepatocellular carcinoma development

Min, L., He, B., & Hui, L. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.011 · Cited by 176 · see citing works

TNFR signaling: ubiquitin‐conjugated TRAFfic signals control stop‐and‐go for MAPK signaling complexes

Karin, M., & Gallagher, E. D. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00755.x · Cited by 178 · see citing works

RORγt protein modifications and IL-17-mediated inflammation

Kumar, R., Theiss, A. L., & Venuprasad, K. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.09.005 · Cited by 174 · see citing works

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

Tsuchiya, Y., Nakabayashi, O., & Nakano, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226232 · Cited by 172 · see citing works

Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells

Zhou, J., Zhang, S., Choon-Nam, O., & Shen, H. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.019 · Cited by 172 · see citing works

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Oshima, S., Turer, E. E., Callahan, J. A., Chai, S., Advincula, R., Barrera, J., Shifrin, N. T., Lee, B. L., Yen, B. C., Woo, T. T., et al. (2008) · Nature · doi:10.1038/nature07575 · Cited by 169 · see citing works

Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer

Bagnoli, M., Canevari, S., & Mezzanzanica, D. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.015 · Cited by 168 · see citing works

Redox Regulation of Tumor Necrosis Factor Signaling

Han, D., Ybanez, M. D., Ahmadi, S., Yeh, K., & Kaplowitz, N. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2611 · Cited by 169 · see citing works

Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression

Guo, L., Zhang, P., Chen, Z., Xia, H., Li, S., Zhang, Y., Kobberup, S., Zou, W., & Lin, J. D. (2017) · Journal of Clinical Investigation · doi:10.1172/jci96324 · Cited by 169 · see citing works

Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

Safa, A. R., & Pollok, K. E. (2011) · Cancers · doi:10.3390/cancers3021639 · Cited by 166 · see citing works

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

Melino, G., Gallagher, E. D., Aqeilan, R. I., Knight, R. A., Peschiaroli, A., Rossi, M., Scialpi, F., Malatesta, M., Zocchi, L., Browne, G. J., et al. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.60 · Cited by 168 · see citing works

Research Highlights

(2006) · Nature Immunology · doi:10.1038/ni0406-373

An antiapoptotic protein, c‐FLIPL, directly binds to MKK7 and inhibits the JNK pathway

Nakajima, A., Komazawa‐Sakon, S., Takekawa, M., Sasazuki, T., Yeh, W., Yagita∥, H., Okumura, K., & Nakano, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601423 · Cited by 94 · see citing works

Tumor Necrosis Factor (TNF) Receptor-associated Factor 7 Is Required for TNFα-induced Jun NH2-terminal Kinase Activation and Promotes Cell Death by Regulating Polyubiquitination and Lysosomal Degradation of c-FLIP Protein

Scudiero, I., Zotti, T., Ferravante, A., Vessichelli, M., Reale, C., Masone, M. C., Leonardi, A., Vito, P., & Stilo, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.300137 · Cited by 48 · see citing works

A Five-Year Itch in TNF-α Cytotoxicity: The Time Factor Determines JNK Action

Lin, A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.006 · Cited by 19 · see citing works

The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

Tang, F., Tang, G., Xiang, J., Dai, Q., Rosner, M. R., & Lin, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8571-8579.2002 · Cited by 145 · see citing works