The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Sox9 and p300 Cooperatively Regulate Chromatin-mediated Transcription
Open accessAbstract
Chromatin structure is a fundamental component of gene regulation, expression, and cellular differentiation. We have previously reported that the multifunctional coactivator p300 is a member of the Sox9 (Sry-type high mobility group box 9)-related transcriptional apparatus and activates Sox9-dependent transcription during chondrogenesis. However, the mechanism of synergy between Sox9 and p300 in chromatin-mediated transcription has not been elucidated. In the present study we investigated the activity of Sox9 and p300 on chromatinized templates in vitro. Recombinant Sox9 was shown to be associated with several transcriptional cofactors including p300. In vitro transcription assays revealed that p300 potentiated Sox9-dependent transcription on chromatinized DNA and, importantly, was associated with hyperacetylated histones. Consistent with these results, the histone deacetylase inhibitor trichostatin A stimulated the expression of Sox9-regulated cartilage matrix genes and induced histone acetylation around the enhancer region of the collagen alpha1 (II) gene in chondrocytes. These findings suggest that Sox9 interacts with chromatin and activates transcription via regulation of chromatin modification.
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Kitagawa, H., Fujiki, R., Yoshimura, K., Mezaki, Y., Uematsu, Y., Matsui, D., Ogawa, S., Unno, K., Okubo, M., Tokita, A., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00436-7 · Cited by 268
Self-citationRetractedJaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
Petrif, F., Giles, R. H., Dauwerse, H. G., Saris, J. J., Hennekam, R. C. M., Masuno, M., Tommerup, N., van Ommen, G.-J. B., Goodman, R. H., Peters, D. J. M., et al. (1995) · Nature · doi:10.1038/376348a0 · Cited by 1,217
Signaling to Chromatin through Histone Modifications
Cheung, P., Allis, C. D., & Sassone-Corsi, P. (2000) · Cell · doi:10.1016/s0092-8674(00)00118-5 · Cited by 989
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Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte
Ohba, S., He, X., Hojo, H., & McMahon, A. P. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.013 · Cited by 179
Liu, C.-F., Angelozzi, M., Haseeb, A., & Lefebvre, V. (2018) · Development · doi:10.1242/dev.164459 · Cited by 73
Metadata
- Authors
- Furumatsu, T., Tsuda, M., Yoshida, K., Taniguchi, N., Ito, T., Hashimoto, M., Ito, T., & Asahara, H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 280
- Issue
- 42
- Pages
- 35203-35208
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2058255189
- Cited by
- 164
- References
- 5
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Furumatsu, T., Tsuda, M., Yoshida, K., Taniguchi, N., Ito, T., Hashimoto, M., Ito, T., & Asahara, H. (2005). Sox9 and p300 Cooperatively Regulate Chromatin-mediated Transcription. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m502409200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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