The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mammalian Selenoprotein Thioredoxin-glutathione Reductase
Open accessAbstract
Thioredoxin reductases (TRs) are important redox regulatory enzymes, which control the redox state of thioredoxins. Mammals have cytosolic and mitochondrial TRs, which contain an essential selenocysteine residue and reduce cytosolic and mitochondrial thioredoxins. In addition, thioredoxin/glutathione reductase (TGR) was identified, which is a fusion of an N-terminal glutaredoxin domain and the TR module. Here we show that TGR is expressed at low levels in various tissues but accumulates in testes after puberty. The protein is particularly abundant in elongating spermatids at the site of mitochondrial sheath formation but is absent in mature sperm. We found that TGR can catalyze isomerization of protein and interprotein disulfide bonds and localized this function to its thiol domain. TGR targets include proteins that form structural components of the sperm, including glutathione peroxidase GPx4/PHGPx. Together, TGR and GPx4 can serve as a novel disulfide bond formation system. Both enzymes contain a catalytic selenocysteine consistent with the role of selenium in male reproduction.
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Conrad, M., Jakupoglu, C., Moreno, S. G., Lippl, S., Banjac, A., Schneider, M., Beck, H., Hatzopoulos, A. K., Just, U., Sinowatz, F., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9414-9423.2004 · Cited by 485
Moustafa, M. E., Carlson, B. A., El-Saadani, M. A., Kryukov, G. V., Sun, Q.-A., Harney, J. W., Hill, K. E., Combs, G. F., Feigenbaum, L., Mansur, D. B., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3840-3852.2001 · Cited by 131
Self-citation
Cited by
Selenium, Selenoproteins, and Immunity
Avery, J., & Hoffmann, P. (2018) · Nutrients · doi:10.3390/nu10091203 · Cited by 894
Selenium biochemistry and its role for human health
Roman, M., Jitaru, P., & Barbante, C. (2014) · Metallomics · doi:10.1039/c3mt00185g · Cited by 823
Thioredoxin and Related Molecules–From Biology to Health and Disease
Lillig, C. H., & Holmgren, A. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.9.25 · Cited by 724
Hanschmann, E.-M., Godoy, J. R., Berndt, C., Hudemann, C., & Lillig, C. H. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4599 · Cited by 677
Lillig, C. H., Berndt, C., & Holmgren, A. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.06.003 · Cited by 561
Metadata
- Authors
- Su, D., Novoselov, S. V., Sun, Q.-A., Moustafa, M. E., Zhou, Y., Oko, R., Hatfield, D. L., & Gladyshev, V. N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 280
- Issue
- 28
- Pages
- 26491-26498
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1966815619
- Cited by
- 204
- References
- 2
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Su, D., Novoselov, S. V., Sun, Q.-A., Moustafa, M. E., Zhou, Y., Oko, R., Hatfield, D. L., & Gladyshev, V. N. (2005). Mammalian Selenoprotein Thioredoxin-glutathione Reductase. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m503638200
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