The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Selenium, Selenoproteins, and Immunity
Open accessAbstract
Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. The selenoproteome contains 25 members in humans that exhibit a wide variety of functions. The development of high-throughput omic approaches and novel bioinformatics tools has led to new insights regarding the effects of selenium and selenoproteins in human immuno-biology. Equally important are the innovative experimental systems that have emerged to interrogate molecular mechanisms underlying those effects. This review presents a summary of the current understanding of the role of selenium and selenoproteins in regulating immune cell functions and how dysregulation of these processes may lead to inflammation or immune-related diseases.
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Cites
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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
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Self-citationSelenium biochemistry and its role for human health
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Cited by
Childs, C. E., Calder, P. C., & Miles, E. A. (2019) · Nutrients · doi:10.3390/nu11081933 · Cited by 532
Nutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition, Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 426
Selenium in thyroid disorders—essential knowledge for clinicians
Winther, K. H., Rayman, M. P., Bonnema, S. J., & Hegedüs, L. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0311-6 · Cited by 288
Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review
Zhang, Y., Roh, Y. J., Han, S.-J., Park, I., Lee, H. M., Ok, Y. S., Lee, B. C., & Lee, S.-R. (2020) · Antioxidants · doi:10.3390/antiox9050383 · Cited by 267
Mineral Micronutrients in Asthma
Zajac, D. (2021) · Nutrients · doi:10.3390/nu13114001 · Cited by 33
Metadata
- Authors
- Avery, J., & Hoffmann, P.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-09-01
- Volume
- 10
- Issue
- 9
- Pages
- 1203
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2889290358
- Cited by
- 894
- References
- 161
- FWCI
- 44.17
- Type
- journal article
- Language
- en
- Open access
- gold
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