The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Tyrosine Phosphorylation of VE-cadherin Prevents Binding of p120- and β-Catenin and Maintains the Cellular Mesenchymal State
Open accessAbstract
In several pathological conditions, epithelial cells demonstrate a breakdown of barrier function and acquire an invasive phenotype. Endothelial cells in particular are maintained in a mesenchymal state during the cell invasion phase of angiogenesis. We show here that tyrosine phosphorylation of the adherens junction protein VE-cadherin at two critical tyrosines, Tyr-658 and Tyr-731, via tyrosine kinase activation or phosphatase inactivation was sufficient to prevent the binding of p120- and beta-catenin, respectively, to the cytoplasmic tail of VE-cadherin. In fact, phosphorylation at either site led to the inhibition of cell barrier function. Cells expressing wild-type VE-cadherin showed decreased cell migration compared with cells lacking VE-cadherin, whereas expression of VE-cadherin with a simple phosphomimetic tyrosine-to-glutamic acid mutation of Y658E or Y731E was sufficient to restore the migratory response. These findings demonstrate that a single phosphorylation event within the VE-cadherin cytoplasmic tail is sufficient to maintain cells in a mesenchymal state.
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Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R. A., Come, C., Savagner, P., Gitelman, I., Richardson, A., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,855
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
Gumbiner, B. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81279-9 · Cited by 3,471
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
Hicklin, D. J., & Ellis, L. M. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.06.081 · Cited by 3,007
Epithelial–mesenchymal transitions in development and pathologies
Thiery, J. P. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.10.006 · Cited by 1,704
Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
Cavallaro, U., & Christofori, G. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1276 · Cited by 1,311
Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability
Eliceiri, B. P., Paul, R., Schwartzberg, P. L., Hood, J. D., Leng, J., & Cheresh, D. A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80221-x · Cited by 813
Self-citationE-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.
Berx, G., Cleton-Jansen, A. M., Nollet, F., de Leeuw, W. J., van de Vijver, M., Cornelisse, C., & van Roy, F. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00301.x · Cited by 775
Perez-Moreno, M., Jamora, C., & Fuchs, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00108-9 · Cited by 721
Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells
Esser, S., Lampugnani, M. G., Corada, M., Dejana, E., & Risau, W. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.13.1853 · Cited by 715
Regulation of E-cadherin/Catenin Association by Tyrosine Phosphorylation
Roura, S., Miravet, S., Piedra, J., de Herreros, A. G., & Duñach, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36734 · Cited by 603
Cited by
Gavard, J., & Gutkind, J. S. (2006) · Nature Cell Biology · doi:10.1038/ncb1486 · Cited by 1,018
The role of adherens junctions and VE-cadherin in the control of vascular permeability
Dejana, E., Orsenigo, F., & Lampugnani, M. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.017897 · Cited by 986
Vestweber (2008) · doi:10.1161/atvbaha.107.158014 · Cited by 806
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies
Claesson-Welsh, L., Dejana, E., & McDonald, D. M. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.11.006 · Cited by 631
Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis
Wallez, Y., & Huber, P. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.09.003 · Cited by 473
Metadata
- Authors
- Potter, M. D., Barbero, S., & Cheresh, D. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 280
- Issue
- 36
- Pages
- 31906-31912
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2068793465
- Cited by
- 337
- References
- 36
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Potter, M. D., Barbero, S., & Cheresh, D. A. (2005). Tyrosine Phosphorylation of VE-cadherin Prevents Binding of p120- and β-Catenin and Maintains the Cellular Mesenchymal State. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m505568200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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