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Cited by 631

The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.

Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

Open access
Claesson-Welsh, Lena, Dejana, Elisabetta, McDonald, Donald M.·2021·Trends in Molecular Medicine
DOI 10.1016/j.molmed.2020.11.006
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Abstract

Leakage from blood vessels into tissues is governed by mechanisms that control endothelial barrier function to maintain homeostasis.Dysregulated endothelial permeability contributes to many conditions and can influence disease morbidity and treatment.Diverse approaches used to study endothelial permeability have yielded a wealth of valuable insights.Yet, ongoing questions, technical challenges, and unresolved controversies relating to the mechanisms and relative contributions of barrier regulation, transendothelial sieving, and transport of fluid, solutes, and particulates complicate interpretations in the context of vascular physiology and pathophysiology.Here, we describe recent in vivo findings and other advances in understanding endothelial barrier function with the goal of identifying and reconciling controversies over cellular and molecular processes that regulate the vascular barrier in health and disease.Gap formation requires changes in the organization of tight junctions and adherens junctions that join endothelial cells and create a barrier.Adherens junction opening requires phosphorylation, loss of homophilic interactions, and internalization of VE-cadherin accompanied by changes in the cortical cytoskeleton.Sustained hyperpermeability in pathologic conditions can lead to edema, reduced vascular perfusion, impaired drug delivery, and exaggerated disease severity.

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Metadata

Authors
Claesson-Welsh, L., Dejana, E., & McDonald, D. M.
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2021-04
Volume
27
Issue
4
Pages
314-331
ISSN
1471-4914 (ISSN-L)
DOI
10.1016/j.molmed.2020.11.006
OpenAlex
W3111954174
Cited by
631
References
135
FWCI
8.44
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies. https://app.cochat.ai/papers/10.1016/j.molmed.2020.11.006
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Claesson-Welsh, L., Dejana, E., & McDonald, D. M. (2021). Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2020.11.006

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.