Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer

Wilson, Andrew J.; Byun, Do-Sun; Popova, Natalia; Murray, Lucas B.; L'Italien, Kaitlin; Sowa, Yoshihiro; Arango, Diego; Velcich, Anna; Augenlicht, Leonard H.; Mariadason, John M.

doi:10.1074/jbc.m510023200

Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer

Inhibitors of histone deacetylases (HDACs) induce growth arrest, differentiation, and apoptosis of colon cancer cell lines in vitro and have demonstrated anti-cancer efficacy in clinical trials. Whereas a role for HDAC1 and -2 in mediating components of the HDAC inhibitor response has been report…