Cited by 397Cell death mechanisms and regulationCancer-related Molecular PathwaysNF-κB Signaling Pathways

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The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases

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Eckelman, Brendan P., Salvesen, Guy S.·2006·Journal of Biological Chemistry

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Abstract

cIAPs (cellular inhibitor of apoptosis proteins) 1 and 2 are able to regulate apoptosis when ectopically expressed in recipient cells and probably also in vivo. Previous work suggested that this is at least partially due to direct caspase inhibition, mediated by two of the three baculovirus IAP repeat (BIR) domains that are contained in these proteins. In support of this we show that the BIR domains 2 and 3 of the two cIAPs are able to bind caspases-7 and -9. However, we demonstrate that neither of these BIR domains is able to inhibit caspases because of critical substitutions in the regions that target caspase inhibition in the X-linked IAP, a tight binding caspase inhibitor. The cIAP BIR domains can be converted to tight binding caspase inhibitors by substituting these critical residues with XIAP residues. Thus, cIAPs maintain protein scaffolds suitable for direct caspase inhibition but have lost or never acquired specific caspase inhibitory interaction sites. Consequently, although the binding function of the cIAP BIRs may be important for their physiologic function, caspase inhibition is not.

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Additional file 3 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
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Additional file 13 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
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Additional file 1 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13636990
Additional file 11 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13636981
Additional file 2 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13636993
Additional file 6 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13637005
Additional file 10 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13636978
Additional file 7 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13637008
Additional file 5 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13637002
Additional file 12 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13636984
Additional file 9 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13637014
Additional file 4 of The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
Song, H., Guo, X., Sun, L., Wang, Q., Han, F., Wang, H., Wray, G. A., Davidson, P. L., Wang, Q., Hu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13636999
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BindingDB (2007) · UC San Diego · doi:10.7270/q2g15z34
BindingDB Entry 50045720: The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity.
BindingDB (2016) · UC San Diego · doi:10.7270/q2rf5wq0
Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
Yalcin-Chin, A. (2008)

Authors: Eckelman, B. P., & Salvesen, G. S.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Salvesen, Guy S.
ORCID: Eckelman, Brendan P.
Salvesen, Guy S.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2006-02
Volume: 281
Issue: 6
Pages: 3254-3260
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m510863200
OpenAlex: W2148894303
Cited by: 391
References: 45
Citations by year: 2026: 2 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 9 · 2021: 25 · 2020: 13 · 2019: 17 · 2018: 20 · 2017: 10 · 2016: 19 · 2015: 24 · 2014: 27 · 2013: 22 · 2012: 24
FWCI: 9.79
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5353 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG15402, R01AG015402)
National Cancer Institute (2T32CA77109, T32CA077109)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: cIAP1, cIAP2, caspase inhibition, caspase-7, caspase-9, XIAP, protein-protein binding, apoptosis regulation
MeSH terms: Amino Acid Sequence, Cell Line, Enzyme Inhibitors, Escherichia coli, Humans, Kinetics, Molecular Sequence Data, Protein Binding, Recombinant Proteins, Immunoblotting, Apoptosis, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Caspases, Inhibitor of Apoptosis Proteins, X-Linked Inhibitor of Apoptosis Protein, Caspase 3, Caspase 7, Caspase 9, Caspase Inhibitors

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The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases

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