Salvesen, Guy S.

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 4,268

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 3,686

IAP proteins: blocking the road to death's door

Salvesen, G. S., & Duckett, C. S. (2002) · Nature Reviews Molecular Cell Biology

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 1,756

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,363

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S., & Green, D. R. (2011) · Nature

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 1,278

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature

Adenosine and Purinergic SignalingCell death mechanisms and regulation

Cited by 1,120

The apoptosome: Signalling platform of cell death

Riedl, S. J., & Salvesen, G. S. (2007) · Nature Reviews Molecular Cell Biology

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 1,097

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

Eckelman, B. P., Salvesen, G. S., & Scott, F. L. (2006) · The EMBO Reports

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 813

Caspase-9 Can Be Activated without Proteolytic Processing

Stennicke, H. R., Deveraux, Q. L., Humke, E. W., Reed, J. C., Dixit, V. M., & Salvesen, G. S. (1999) · Journal of Biological Chemistry

Cell death mechanisms and regulationInflammasome and immune disorders

Cited by 497

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

Droga-Mazovec, G., Bojič, L., Petelin, A., Ivanova, S., Romih, R., Repnik, U., Salvesen, G. S., Stoka, V., Turk, V., & Turk, B. (2008) · Journal of Biological Chemistry

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 399

The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases

Eckelman, B. P., & Salvesen, G. S. (2006) · Journal of Biological Chemistry

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 391

The Fas–FADD death domain complex structure unravels signalling by receptor clustering

Scott, F. L., Stec, B., Pop, C., Dobaczewska, M. K., Lee, J. J., Monosov, E., Robinson, H., Salvesen, G. S., Schwarzenbacher, R., & Riedl, S. J. (2009) · Nature

Cell death mechanisms and regulationProtein Structure and Dynamics

Cited by 384

Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 Activation

Oberst, A., Pop, C., Tremblay, A. G., Blais, V., Denault, J.-B., Salvesen, G. S., & Green, D. R. (2010) · Journal of Biological Chemistry

Cell death mechanisms and regulationInflammasome and immune disorders

Cited by 214

Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

Kasperkiewicz, P., Poreba, M., Snipas, S. J., Parker, H., Winterbourn, C. C., Salvesen, G. S., & Drag, M. (2014) · Proceedings of the National Academy of Sciences

Protease and Inhibitor MechanismsChemical Synthesis and Analysis

Cited by 189

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

Lu, J. V., Weist, B. M., van Raam, B. J., Marro, B. S., Nguyen, L. V., Srinivas, P., Bell, B. D., Luhrs, K. A., Lane, T. E., Salvesen, G. S., et al. (2011) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationT-cell and B-cell Immunology

Cited by 122