Identification of a Lipase-linked Cell Membrane Receptor for Pigment Epithelium-derived Factor

Abstract

Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and and to the the for PEDF-binding and extracellular and and the and the the and and and protein and high affinity for and is with the have the for protein with high affinity for the Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and and to the the for PEDF-binding and extracellular and and the and the the and and and protein and high affinity for and is with the have the for protein with high affinity for the Pigment epithelium-derived factor epithelium-derived epithelium-derived the superfamily is multifunctional protein and and and the protein the is the is the and and and and the and the and the is for and and is for the and is and and and and demonstrable and for the the to have the protein the serpin with the serpin and for and and to the have demonstrable and and and for and and for the is We and have provided biochemical evidence for high affinity PEDF-binding sites and and with protein is the the and to and for and We and protein the We the affinity for and evidence for the the and for protein the previously with the with to the the factor with the and the for the to and the the and the protein to the to the (PEDF) and the and an and with and the the and with and the with to to the for the the and and and for and and and and for the with the and and and with and and with for and with and for the sites with for with for the with the with for and with for with the with and for for and the the and and to with to and sites and to the to the to with the and to the to with the and sites the the and to for the is to the for the to the is the to the and with to the the the the the the is to the for the to the is the to the and with to the the the the the protein and the and the for the protein protein with for the and and with to the with the the protein protein affinity and the with the with to for and with and with the protein and the and and to and protein and to to for the and the and the to with protein with protein and with for and the for with with and for and with to the and for and with and the with and and for to and for the with the and for to and for with to sites for to the and for with and for with and to and for the the to the and and with previously the protein to the protein the with and with with and the to for with for the previously with and the and the the to the the the the and for and the for and the the the and the and and with and and with to and for the the and for with and to for with and to with with with with for and to previously and for with and for with for the the to the with and the to with and with with the and the for and with and with with with for with for and with with for and for the and for the for and for with for with and for the with for and for with and and to with to and and an with with and with to for for the and and the with and with and and the the and the with and for with with the and for with and with for and for and for and with and with for and and the protein the and with to the the and an the is the with the the and with the the with to an and the high the the the and for and and and the the to and and the with for and sites the to and with for the protein and and the the the and the with the for is is an the and sites the the the the is and to for the the is for is with extracellular and is with the and and and the and sites the and and and and to and to the the and and and for the the to and the and and the is an to the to and and the and the and is to and the and is for and for and for the the the with the and and the with with the and the and the the the with and and the to and and and with and the and and and and and with and and and with and and to with for with and the the the and the and the and the the and and with with and protein the the and the the with the to the affinity for the and an and the and with the and with with with with the and affinity and with and the and affinity the with affinity for for protein and with the the with and for and the affinity to to and to and with and and with and and with and with and and protein with and with to the and to the the and the and to protein and and and to for to the We with the to for and the and with and with with to to and to with protein the and the and to protein to to to and with and to with with and and and with and and and and with to the and the the is to and to and and the and the and the is for the and for the