Aberrant Hepatic Expression of PPARγ2 Stimulates Hepatic Lipogenesis in a Mouse Model of Obesity, Insulin Resistance, Dyslipidemia, and Hepatic Steatosis

Zhang, Yuan-Li; Hernandez-Ono, Antonio; Siri, Patty; Weisberg, Stuart; Conlon, Donna; Graham, Mark J.; Crooke, Rosanne M.; Huang, Li-Shin; Ginsberg, Henry N.

doi:10.1074/jbc.m604709200

Cited by 147

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Aberrant Hepatic Expression of PPARγ2 Stimulates Hepatic Lipogenesis in a Mouse Model of Obesity, Insulin Resistance, Dyslipidemia, and Hepatic Steatosis

Zhang, Yuan-Li, Hernandez-Ono, Antonio, Siri, Patty, Weisberg, Stuart, Conlon, Donna, Graham, Mark J., Crooke, Rosanne M., Huang, Li-Shin, Ginsberg, Henry N.·2006·Journal of Biological Chemistry

DOI 10.1074/jbc.m604709200

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Hepatic PPARγ plays important roles in HFD-induced up-regulation of lipogenic genes and de novo lipogenesis.
“and this may also have contributed to the reduced hepatic lipogenesis, as hepatic PPARγ plays important roles in HFD-induced up-regulation of lipogenic genes and de novo lipogenesis.53–55”
From (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis (2018) · cites this paper as [55]

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity
Stiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W. P., Kim, Y.-J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308617100 · Cited by 436
Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression
Seo, J. B., Moon, H. M., Kim, W. S., Lee, Y. S., Jeong, H. W., Yoo, E. J., Ham, J., Kang, H., Park, M.-G., Steffensen, K. R., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3430-3444.2004 · Cited by 250
Iron‐ and inflammation‐induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo†
Lou, D., Lesbordes, J., Nicolas, G., Viatte, L., Bennoun, M., Van Rooijen, N., Kahn, A., Renia, L., & Vaulont, S. (2005) · Hepatology · doi:10.1002/hep.20663 · Cited by 62

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Research works printed but not linked: 57

Voyiaziakis, 1999, J. Lipid Res., 40, 2004, 10.1016/S0022-2275(20)32424-X · DOI
Siri, 2001, J. Biol. Chem., 276, 46064, 10.1074/jbc.M108909200 · DOI
Fisher, 2002, J. Biol. Chem., 277, 17377, 10.1074/jbc.R100068200 · DOI
Gordon, 2000, Biochim. Biophys. Acta, 1486, 72, 10.1016/S1388-1981(00)00049-4 · DOI
Twisk, 2000, J. Clin. Investig., 105, 521, 10.1172/JCI8623 · DOI
Browning, 2004, Hepatology, 40, 1387, 10.1002/hep.20466 · DOI · Paper page
Uyeda, 2002, Biochem. Pharmacol., 63, 2075, 10.1016/S0006-2952(02)01012-2 · DOI
Matsusue, 2003, J. Clin. Investig., 111, 737, 10.1172/JCI200317223 · DOI · Paper page
Gavrilova, 2003, J. Biol. Chem., 278, 34268, 10.1074/jbc.M300043200 · DOI · Paper page
Herzig, 2003, Nature, 426, 190, 10.1038/nature02110 · DOI
Folch, 1957, J. Biol. Chem., 224, 497, 10.1016/S0021-9258(18)64849-5 · DOI · Paper page
Shimano, 1996, J. Clin. Investig., 98, 1575, 10.1172/JCI118951 · DOI
Ko, 2003, J. Lipid Res., 44, 1946, 10.1194/jlr.M300172-JLR200 · DOI
Sheng, 1995, Proc. Natl. Acad. Sci. U. S. A., 92, 935, 10.1073/pnas.92.4.935 · DOI · Paper page
Tzung, 1994, Genomics, 21, 244, 10.1006/geno.1994.1250 · DOI
Latasa, 2000, Proc. Natl. Acad. Sci. U. S. A., 97, 10619, 10.1073/pnas.180306597 · DOI
Van Rooijen, 1994, J. Immunol. Methods, 174, 83, 10.1016/0022-1759(94)90012-4 · DOI
Weisberg, 2003, J. Clin. Investig., 112, 1796, 10.1172/JCI200319246 · DOI · Paper page
Siri, 2003, Metabolism, 52, 659, 10.1016/S0026-0495(03)00061-1 · DOI
Miyazaki, 2001, J. Lipid Res., 42, 1018, 10.1016/S0022-2275(20)31589-3 · DOI
Shimomura, 1999, J. Biol. Chem., 274, 30028, 10.1074/jbc.274.42.30028 · DOI
Repa, 2000, Genes Dev., 14, 2819, 10.1101/gad.844900 · DOI
Costet, 2000, J. Biol. Chem., 275, 28240, 10.1074/jbc.M003337200 · DOI
Lee, 2006, Proc. Natl. Acad. Sci. U. S. A., 103, 3444, 10.1073/pnas.0511253103 · DOI
Vidal-Puig, 1996, J. Clin. Investig., 97, 2553, 10.1172/JCI118703 · DOI
Bellentani, 2000, Ann. Intern. Med., 132, 112, 10.7326/0003-4819-132-2-200001180-00004 · DOI
Yki-Jarvinen, 2005, Ann. Intern. Med., 37, 347, 10.1080/07853890510037383 · DOI
Tanoli, 2004, J. Lipid Res., 45, 941, 10.1194/jlr.M300508-JLR200 · DOI
Wetterau, 1992, Science, 258, 999, 10.1126/science.1439810 · DOI
Taghibiglou, 2000, J. Biol. Chem., 275, 8416, 10.1074/jbc.275.12.8416 · DOI
Salmon, 1973, Biochemistry, 136, 551
Kissebah, 1982, Diabetes, 31, 217, 10.2337/diab.31.3.217 · DOI
Myerson, 2005, J. Lipid Res., 46, 2735, 10.1194/jlr.M500335-JLR200 · DOI
Kissebah, 1974, Clin. Sci. Mol. Med., 47, 259
Lewis, 1999, Curr. Opin. Lipidol., 10, 475, 10.1097/00041433-199910000-00015 · DOI
Diraison, 1998, Am. J. Physiol., 274, E321
Hellerstein, 1999, Eur. J. Clin. Nutr., 53, S53, 10.1038/sj.ejcn.1600744 · DOI
Shimomura, 1999, Proc. Natl. Acad. Sci. U. S. A., 96, 13656, 10.1073/pnas.96.24.13656 · DOI
Chen, 2004, Proc. Natl. Acad. Sci. U. S. A., 101, 11245, 10.1073/pnas.0404297101 · DOI
Shimomura, 2000, Mol. Cell, 6, 77, 10.1016/S1097-2765(05)00010-9 · DOI
Schultz, 2000, Genes Dev., 14, 2831, 10.1101/gad.850400 · DOI · Paper page
Joseph, 2002, J. Biol. Chem., 277, 11019, 10.1074/jbc.M111041200 · DOI
Ishii, 2004, Proc. Natl. Acad. Sci. U. S. A., 101, 15597, 10.1073/pnas.0405238101 · DOI
Iizuka, 2004, Proc. Natl. Acad. Sci. U. S. A., 101, 7281, 10.1073/pnas.0401516101 · DOI
Mensenkamp, 2004, Hepatology, 40, 599, 10.1016/j.jhep.2003.12.011 · DOI
Rosen, 2001, J. Biol. Chem., 276, 37731, 10.1074/jbc.R100034200 · DOI
Memon, 2000, Endocrinology, 141, 4021, 10.1210/endo.141.11.7771 · DOI
Moitra, 1998, Genes Dev., 12, 3168, 10.1101/gad.12.20.3168 · DOI
Yu, 2003, J. Biol. Chem., 278, 498, 10.1074/jbc.M210062200 · DOI
Schadinger, 2005, Am. J. Physiol., 288, E1195
Uno, 2006, Science, 312, 1656, 10.1126/science.1126010 · DOI
Edvardsson, 2006, Biochem. Biophys. Res. Commun., 340, 111, 10.1016/j.bbrc.2005.12.008 · DOI
Horie, 2004, J. Clin. Investig., 113, 1774, 10.1172/JCI20513 · DOI
Elam, 2001, J. Lipid Res., 42, 2039, 10.1016/S0022-2275(20)31533-9 · DOI
Adiels, 2005, Arterioscler. Thromb. Vasc. Biol., 25, 1697, 10.1161/01.ATV.0000172689.53992.25 · DOI
Chan, 2004, Clin. Sci. (Lond.), 107, 233, 10.1042/CS20040109 · DOI
Castro Cabezas, 1993, J. Clin. Investig., 92, 160, 10.1172/JCI116544 · DOI

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Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151
Toll‐like receptor‐4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non‐alcoholic steatohepatitis
Rivera, C. A., Adegboyega, P., van Rooijen, N., Tagalicud, A., Allman, M., & Wallace, M. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.04.019 · Cited by 693
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
Knutson, S. K., Chyla, B. J., Amann, J. M., Bhaskara, S., Huppert, S. S., & Hiebert, S. W. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.51 · Cited by 271
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Sowa, N., Yahagi, N., et al. (2013) · Nature Communications · doi:10.1038/ncomms3883 · Cited by 230
(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis
Ren, L., Sun, Y., Lu, H., Ye, D., Han, L., Wang, N., Daugherty, A., Li, F., Wang, M., Su, F., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312422 · Cited by 59

Authors: Zhang, Y.-L., Hernandez-Ono, A., Siri, P., Weisberg, S., Conlon, D., Graham, M. J., Crooke, R. M., Huang, L.-S., & Ginsberg, H. N.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2006-12
Volume: 281
Issue: 49
Pages: 37603-37615
ISSN: 0021-9258
DOI: 10.1074/jbc.m604709200
Cited by: 147
References: 5
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5051 d)

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Aberrant Hepatic Expression of PPARγ2 Stimulates Hepatic Lipogenesis in a Mouse Model of Obesity, Insulin Resistance, Dyslipidemia, and Hepatic Steatosis

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