Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

Matsusue, Kimihiko; Haluzik, Martin; Lambert, Gilles; Yim, Sun-Hee; Gavrilova, Oksana; Ward, Jerrold M.; Brewer, Bryan; Reitman, Marc L.; Gonzalez, Frank J.

doi:10.1172/jci200317223

Cited by 585

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Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

Matsusue, Kimihiko, Haluzik, Martin, Lambert, Gilles, Yim, Sun-Hee, Gavrilova, Oksana, Ward, Jerrold M., Brewer, Bryan, Reitman, Marc L., Gonzalez, Frank J.·2003·Journal of Clinical Investigation

DOI 10.1172/jci200317223

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Liver-specific knockout of Pparg reduces expression of Acaca, Fasn, and Scd1 and hepatic steatosis.
“Whereas it is expressed mostly in adipose tissue, liver-specifi c knockout of Pparg reduces expression of Acaca , Fasn , and Scd1 and hepatic steatosis ( 55,56 ).”
From KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression (2015) · cites this paper as [56]
PPARγ activates genes involved in lipid storage and metabolism.
“PPAR ␥ activates genes involved in lipid storage and metabolism.”
From KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression (2015) · cites this paper as [56]

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Authors: Matsusue, K., Haluzik, M., Lambert, G., Yim, S.-H., Gavrilova, O., Ward, J. M., Brewer, B., Reitman, M. L., & Gonzalez, F. J.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2003-03-01
Volume: 111
Issue: 5
Pages: 737-747
ISSN: 0021-9738
DOI: 10.1172/jci200317223
Cited by: 585
References: 3
Language: en

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Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

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