Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057

The Polycystic Kidney Disease Proteins, Polycystin-1, Polycystin-2, Polaris, and Cystin, Are Co-Localized in Renal Cilia

Yoder, B. K., Hou, X., & Guay-Woodford, L. M. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000029587.47950.25 · Cited by 935

Polycystic Kidney Disease

Wilson, P. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022161 · Cited by 930

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

Hanaoka, K., Qian, F., Boletta, A., Bhunia, A. K., Piontek, K., Tsiokas, L., Sukhatme, V. P., Guggino, W. B., & Germino, G. G. (2000) · Nature · doi:10.1038/35050128 · Cited by 822

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone‐Corsi, P., Townes, T. M., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00344-7 · Cited by 822

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

Lin, F., Hiesberger, T., Cordes, K. R., Sinclair, A. M., Goldstein, L. S. B., Somlo, S., & Igarashi, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0836980100 · Cited by 602

PDGFRαα Signaling Is Regulated through the Primary Cilium in Fibroblasts

Schneider, L., Clement, C. A., Teilmann, S. C., Pazour, G. J., Hoffmann, E. K., Satir, P., & Christensen, S. T. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.012 · Cited by 592

Regulation of the osteoblast‐specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways

Franceschi, R. T., & Xiao, G. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10369 · Cited by 540

Mechanotransduction and strain amplification in osteocyte cell processes

Han, Y., Cowin, S. C., Schaffler, M. B., & Weinbaum, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407429101 · Cited by 495

Molecular pathways mediating mechanical signaling in bone

Rubin, J. E., Rubin, C. T., & Jacobs, C. R. (2005) · Gene · doi:10.1016/j.gene.2005.10.028 · Cited by 481

E-Cadherin and FGFR1 Expression in Mouse Osteoblastogenesis in Normoxic Cultures

Al‐Amer, O. M. (2017) · International Journal of Biomedical Science · doi:10.59566/ijbs.2017.13013 · Cited by 3

The Effect of IFT80 Deficiency in Osteocytes on Orthodontic Loading-Induced and Physiologic Bone Remodeling: In Vivo Study

Jeon, H. H., Kang, J. M., Li, J. (., Kim, D., Yuan, G., Almer, N., Liu, M., & Yang, S. (2022) · Life · doi:10.3390/life12081147 · Cited by 4

The Osteocyte Network as a Source and Reservoir of Signaling Factors

Bonewald, L. F. (2010) · Endocrinology and Metabolism · doi:10.3803/enm.2010.25.3.161 · Cited by 3

Cell Interaction and Mechanobiological Modeling of Bone Remodeling Process

Kahla, R. B., Barkaoui, A., Salah, F. Z. B., & Chafra, M. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.95045 · Cited by 3

Peripheral Blood Mononuclear Cells (PBMCs) to Dissect the Underlying Mechanisms of Bone Disease in Chronic Kidney Disease and Rare Renal Diseases

Bernardor, J., Alioli, C., Méaux, M.-N., Peyruchaud, O., Machuca‐Gayet, I., & Bacchetta, J. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00707-6 · Cited by 4

Genetic Interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial Bone

Bumann, E. E., Leat, P. H., Wang, H. H., Hufft‐Martinez, B. M., Wang, W., & Tran, P. V. (2022) · Journal of Developmental Biology · doi:10.3390/jdb10020017 · Cited by 2

Chronic kidney disease- mineral and bone disorder in autosomal dominant policystic kidney disease

Lai, S., Perrotta, A. M., Tartaglione, L., Mastroluca, D., Tinti, F., Mené, P., Pasquali, M., Ferraro, P. M., Mazzaferro, S., & Rotondi, S. (2025) · Bone · doi:10.1016/j.bone.2025.117652 · Cited by 2

The Molecular Mechanism of Multifunctional Mechano-Gated Channel TRPV4

Suzuki, M., & Mizuno, A. (2012) · Springer eBooks · doi:10.1007/978-94-007-5073-9_4 · Cited by 2

Craniofacial Development and Growth in Polycystic Kidney Disease

Ohazama, A., & Sharpe, P. T. (2015) · Codon Publications eBooks · doi:10.15586/codon.pkd.2015.ch19 · Cited by 2

On the Horizon From the ORS

Grande, D. A., Shah, N. V., Catanzano, A. A., Nelson, F. R. T., Hoey, D. A., & Jacobs, C. R. (2011) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-201101000-00007 · Cited by 2

Osteoblast Biology

Lian, J. B., & Stein, G. S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50007-x · Cited by 2

Exostoses of the Bony Pyramid of the Nose: A Review About an Adaptive Response to Mechanical Stimuli Exerted by In-Flight Oxygen Masks

Schreinemakers, J. R. C., Klein‐Nulend, J., van Lotten, M. L., Nolte, P. A., & Kon, M. (2015) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-015-9187-8 · Cited by 2

Mechanobiological Origins of Osteoporosis

Verbruggen, S. W. (2013) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/17164 · Cited by 2

Bone Cells: Osteoblast/Osteoclast/Osteocyte

Rucci, N., & Teti, A. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64347-7 · Cited by 3

Phosphaturia Exacerbates Tubular Injury and Cyst Formation in Polycystic Kidney Disease

Jansson, K. P., Kuluva, J., Swanson, T., Zhang, S., Fields, T. A., Swenson-Fields, K. I., Wallace, D. P., Rowe, P. S., & Stubbs, J. R. (2026) · Kidney360 · doi:10.34067/kid.0000001149 · Cited by 1

Matrix Competence Failure in Osteoporosis: Mechanosensing, Osteoimmune Crosstalk, and Fragility Beyond Bone Mineral Density

Xia, T.-G., Zhang, Y., Li, S., Zhou, Y., Tian, W., Jiang, Z., Shao, Y., & Wang, J. (2026) · Current Medical Science · doi:10.1007/s11596-026-00235-3 · Cited by 1

Mechanical Stimulation of Bone Cells Using Fluid Flow

Huesa, C., & Bakker, A. D. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-415-5_36 · Cited by 1

Bone Health: Basic and Applied Bone Biology

Miedany, Y. M. E. (2022) · Springer eBooks · doi:10.1007/978-3-030-87950-1_1 · Cited by 1

[Low-frequency pulsed electromagnetic fields promote osteoblast mineralization and maturation of rats through the PC2/sAC/PKA/CREB signaling pathway].

He, Y., Chen, K., Wei, P., Xie, G., Chen, Z., Qin, K., Gao, Y., & Ma, H. (2022) · PubMed Central · doi:10.12122/j.issn.1673-4254.2022.07.04 · Cited by 1

Mechanobiology regulation

McEvoy, E., & McNamara, L. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91821-3.00007-4 · Cited by 1

Mechanobiology of Bone

Dahl, A. C. E., & Thompson, M. S. (2011) · Elsevier eBooks · doi:10.1016/b978-0-08-088504-9.00419-0 · Cited by 3

Establishment of a model of murine odontoblasts underexpressing PKD1 using shRNA.

Thivichon‐Prince, B., Labert, N., Couble, M.-L., & Bleicher, F. (2013) · Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie · Cited by 1

Insulin, fat, and bone: multiple interactions lead to complex biology

Blank, R. D. (2012) · Translational research · doi:10.1016/j.trsl.2012.10.009 · Cited by 1

Osteocyte Mechanobiology in Aging and Disease

Donahue, H. J., Friendman, M. J., & Genetos, D. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817931-4.00001-7 · Cited by 1

Cell Biology of Craniofacial Bone: Osteocytes

Bonewald, L. F. (2012) · doi:10.1002/9781118704868.ch8 · Cited by 1

Roles for cilia in bone cells?

Andrews, N. A. (2006) · BoneKEy-Osteovision · doi:10.1138/20060239 · Cited by 1

Cellular Mechanisms of Mechanotransduction in Bone

Young, S. R. L., & Pavalko, F. M. (2010) · Springer eBooks · doi:10.1007/978-90-481-9881-8_12 · Cited by 1

On the Horizon From the ORS

GIBSON, G. J., & Fyhrie, D. P. (2007) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200701000-00008 · Cited by 1

Differentiation of osteoblasts to osteocytes in 3D type I collagen gels - a novel tool to study osteocyte responses to mechanical loading

Scully, N. E. E. (2015) · ORCA Online Research @Cardiff (Cardiff University)

The genetics of brachyolmia: between cilia and cell volume regulation

Stein, R. (2009) · Clinical Genetics · doi:10.1111/j.1399-0004.2008.01140_1.x

Meeting report from the 28th annual meeting of the American society for bone and mineral research

Schipani, E., Ferrari, S., Datta, N. S., McCauley, L. K., Vignery, A., Bellido, T., Strewler, G. J., Turner, C. H., Jiang, Y., & Seeman, E. (2006) · BoneKEy-Osteovision · doi:10.1138/20060237

Polycystin-1 may play an important role in mechanical modulation of bone growth and healing

Zhang, W., & Wang, L. (2009) · Bioscience hypotheses · doi:10.1016/j.bihy.2009.04.009

Investigating the contributions of TRPP2 and α7 nAChR to mouse auditory function utilising various genetic approaches

Laqua, M. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-16712

Analyse fonctionnelle de la polycystine-1 et de son domaine intracellulaire dans le développement de la polykystose rénale autosomique dominante

Côté, O. (2009) · doi:10.71781/30506

Multiscale Mechanobiology of Primary Cilia

Nguyen, A. M. (2015) · doi:10.7916/d8z60mt0

Effects of the Lyme disease pathogen Borrelia burgdorferi on murine bone biology

Tang, T. (2016) · TSpace (University of Toronto)

Clinical and basic research papers – October 2006 selections

Ferrari, S., Seeman, E., & Strewler, G. J. (2006) · BoneKEy-Osteovision · doi:10.1138/20060234

The effect of bone anabolic stimuli on human osteoblast to osteocyte transition.

Welldon, K. J. (2012) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)

The Roles of Primary Cilia in Cardiovascular Diseases and Cancer

Jamal, M. (2020) · Chapman University Digital Commons (Chapman University) · doi:10.36837/chapman.000172

Genetic interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial BonePreprint

Bumann, E. E., Leat, P. H., Wang, H., Hufft‐Martinez, B. M., Wang, W., & Tran, P. V. (2022) · Preprints.org · doi:10.20944/preprints202204.0150.v1

Osteocytes

Bonewald, L. F. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50009-3

Hierarchical analysis and multiscale modelling of cellular structures

Oftadeh, R. (2015) · doi:10.17760/d20212379

Cilia-Mediated Signaling

Johnson, G. P., Riffault, M., Woods, I., & Hoey, D. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11211-5

Bone Research Society 2015

(2015) · doi:10.3389/978-2-88919-659-3

Bone cells: Osteoblast/osteoclast/osteocyte

Ucci, A., & Rucci, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00158-8

Idiopathic Pubic Symphysis Diastasis in a Patient With Autosomal Dominant Polycystic Kidney Disease: A Rare Case Report

Beridze, L., Vardiashvili, L., Aladashvili, Z., Lekishvili, T., & Kintsurashvili, T. (2025) · Cureus · doi:10.7759/cureus.92657

Additional file 1 of Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes

Allison, H., Holdsworth, G., & McNamara, L. M. (2020) · Figshare · doi:10.6084/m9.figshare.13192087

Progress on the mechanism of Polycystin-1 in bone remodeling

Guo, J., Hu, G.-X., Li, X., Yi, X.-J., Chang, B., & Li, T. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1693704

Mechano-adaptation and mechano-sensing in skeletal biology

Busse, B., & Zimmermann, E. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13683-2.00017-7

Etude du rôle du récepteur LPA1 dans l'ostéogénèse au cours de la croissance du squelette : implication dans l'acquisition de masse osseuse

Alioli, A. C. (2020) · theses.fr (ABES) · doi:10.70675/91ed89a7zfc2fz442fz8da8zad0726b68cdd

Biallelic variants in DNAH10 are associated with skeletal developmental abnormalities and ciliary dysfunction

Zheng, R., Du, X., Yan, J., Huang, G., Guo, Z., Li, W. H., Que, H., Wen, Y., Yan, F., Chen, D., et al. (2026) · Journal of Medical Genetics · doi:10.1136/jmg-2025-111109

The Important Role of Polycystin in the Skeletal System

Zhang, J., Dai, Q., Chen, Q., 牟荣康, Kang, T., & Wu, Z. (2026) · Calcified Tissue International · doi:10.1007/s00223-026-01566-y

Mechanosensing and mechanotransduction in bone cells

Kerdjoudj, H., & Schiavi, J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-26739-0.00023-5

Polycystin-1 Regulates Skeletogenesis through Stimulation of the Osteoblast-specific Transcription Factor RUNX2-II

Xiao, Z., Zhang, S., Magenheimer, B. S., Luo, J., & Quarles, L. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710407200 · Cited by 76

Role of the polycytin‐primary cilia complex in bone development and mechanosensing

Xiao, Z., & Quarles, L. D. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05239.x · Cited by 80

On the Horizon From the ORS

GIBSON, G. J., & Fyhrie, D. P. (2007) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200701000-00008 · Cited by 1

Polycystin-1 Mediates Mechanical Strain-Induced Osteoblastic Mechanoresponses via Potentiation of Intracellular Calcium and Akt/b-Catenin Pathway

Wang, H., Sun, W., Ma, J., Pan, Y., Wang, L., & Zhang, W. (2016)

Polycystin-1 Mediates Mechanical Strain-Induced Osteoblastic Mechanoresponses via Potentiation of Intracellular Calcium and Akt/β-Catenin Pathway

Wang, H., Sun, W. S., Ma, J., Pan, Y., Wang, L., & Zhang, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091730 · Cited by 51