Nephrocan, a Novel Member of the Small Leucine-rich Repeat Protein Family, Is an Inhibitor of Transforming Growth Factor-β Signaling
Open accessAbstract
In a search of new, small leucine-rich repeat proteoglycan/protein (SLRP) family members, a novel gene, nephrocan (NPN), has been identified. The gene consists of three exons, and based on the deduced amino acid sequence, NPN has 17 leucine-rich repeat motifs and unique cysteine-rich clusters both in the N and C termini, indicating that this gene belongs to a new class of SLRP family. NPN mRNA was predominantly expressed in kidney in adult mice, and during mouse embryogenesis, the expression was markedly increased in 11-day-old embryos at a time when early kidney development takes place. In the adult mouse kidney, NPN protein was located in distal tubules and collecting ducts. When NPN was overexpressed in cell culture, the protein was detected in the cultured medium, and upon treatment with N-glycosidase F, the molecular mass was lowered by approximately 14 kDa, indicating that NPN is a secreted N-glycosylated protein. Furthermore, transforming growth factor-beta (TGF-beta)-responsive 3TP promoter luciferase activity was down-regulated, and TGF-beta-induced Smad3 phosphorylation was also inhibited by NPN, suggesting that NPN suppresses TGF-beta/Smad signaling. Taken together, NPN is a novel member of the SLRP family that may play important roles in kidney development and pathophysiology by functioning as an endogenous inhibitor of TGF-beta signaling.
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Nephrocan (Nepn) was identified by Mochida et al. as an inhibitor of Transforming Growth Factor-β signaling.
“Interestingly, 5730521E12Rik is identical to nephrocan (Nepn), which was recently identified by Mochida et al. as an inhibitor of Transforming Growth Factor-β signaling [52].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [52]
5730521E12Rik is identical to nephrocan (Nepn).
“Interestingly, 5730521E12Rik is identical to nephrocan (Nepn), which was recently identified by Mochida et al. as an inhibitor of Transforming Growth Factor-β signaling [52].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [52]
The Abstract identifies nephrocan (NPN) and describes it as an inhibitor of TGF-β signaling. However, neither that passage nor the passages retrieved by searching for “5730521E12Rik” and its RIKEN-clone variant links that identifier to nephrocan, so our copy cannot verify the claimed identity. (LLM, conf=0.76)
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- Authors
- Mochida, Y., Parisuthiman, D., Kaku, M., Hanai, J.-I., Sukhatme, V. P., & Yamauchi, M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Yamauchi, Mitsuo
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 281
- Issue
- 47
- Pages
- 36044-36051
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2150843788
- Cited by
- 34
- References
- 49
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Aeronautics and Space Administration (NAG21596)
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR052824, R21AR052824)
- National Institute of Dental and Craniofacial Research (DE10489, R01DE010489)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- small leucine-rich proteoglycans, TGF-beta signaling, Smad3 phosphorylation, kidney development, distal tubule, collecting duct, N-glycosylation, secreted proteins, embryonic kidney, gene expression
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, Cloning, Molecular, Glycoproteins, Humans, Kidney, Leucine, Molecular Sequence Data, Phylogeny, Tissue Distribution, Signal Transduction, Transforming Growth Factor beta, Gene Expression Regulation, Developmental, Intercellular Signaling Peptides and Proteins, Mice
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