The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
MEKK1 Is Required for MPK4 Activation and Regulates Tissue-specific and Temperature-dependent Cell Death in Arabidopsis
Open accessAbstract
Innate immunity signaling pathways in both animals and plants are regulated by mitogen-activated protein kinase (MAPK) cascades. An Arabidopsis MAPK cascade (MEKK1, MKK4/MKK5, and MPK3/MPK6) has been proposed to function downstream of the flagellin receptor FLS2 based on biochemical assays using transient overexpression of candidate components. To genetically test this model, we characterized two mekk1 mutants. We show here that MEKK1 is not required for flagellin-triggered activation of MPK3 and MPK6. Instead, MEKK1 is essential for activation of MPK4, a MAPK that negatively regulates systemic acquired resistance. We also showed that MEKK1 negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are partly dependent on both RAR1, a key component in resistance protein function, and SID2, an isochorismate synthase required for salicylic acid production upon pathogen infection.
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Cites
Host-Microbe Interactions: Shaping the Evolution of the Plant Immune Response
Chisholm, S. T., Coaker, G., Day, B., & Staskawicz, B. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.008 · Cited by 2,957
Emerging MAP kinase pathways in plant stress signalling
Nakagami, H., Pitzschke, A., & Hirt, H. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.05.009 · Cited by 676
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CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis
Miya, A., Albert, P., Shinya, T., Desaki, Y., Ichimura, K., Shirasu, K., Narusaka, Y., Kawakami, N., Kaku, H., & Shibuya, N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705147104 · Cited by 1,427
Self-citationMAPK Cascades in Plant Disease Resistance Signaling
Meng, X., & Zhang, S. (2013) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-082712-102314 · Cited by 1,367
Signaling Mechanisms in Pattern-Triggered Immunity (PTI)
Bigeard, J., Colcombet, J., & Hirt, H. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.12.022 · Cited by 1,105
Mitogen-Activated Protein Kinase Signaling in Plants
Cristina, M., Petersen, M., & Mundy, J. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112252 · Cited by 1,103
Metadata
- Authors
- Ichimura, K., Casais, C., Peck, S. C., Shinozaki, K., & Shirasu, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 281
- Issue
- 48
- Pages
- 36969-36976
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2075068237
- Cited by
- 293
- References
- 2
- FWCI
- 22.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ichimura, K., Casais, C., Peck, S. C., Shinozaki, K., & Shirasu, K. (2006). MEKK1 Is Required for MPK4 Activation and Regulates Tissue-specific and Temperature-dependent Cell Death in Arabidopsis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m605319200
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