The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transient Receptor Potential Channel A1 Is Directly Gated by Calcium Ions
Open accessAbstract
Members of the superfamily of transient receptor potential (TRP) channels are proposed to play important roles in sensory physiology. As an excitatory ion channel TRPA1 is robustly activated by pungent irritants in mustard and garlic and is suggested to mediate the inflammatory actions of environmental irritants and proalgesic agents. Here, we demonstrate that, in addition to pungent natural compounds, Ca(2+) directly gates heterologously expressed TRPA1 in whole-cell and excised-patch recordings with an apparent EC(50) of 905 nm. Pharmacological experiments and site-directed mutagenesis indicate that the N-terminal EF-hand calcium-binding domain of the channel is involved in Ca(2+)-dependent activation. Furthermore, we determine Ca(2+) as prerequisite for icilin activity on TRPA1.
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Citations
Cites
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Cited by
Trevisani, M., Siemens, J., Materazzi, S., Bautista, D. M., Nassini, R., Campi, B., Imamachi, N., Andrè, E., Patacchini, R., Cottrell, G. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705923104 · Cited by 770
Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress
Andersson, D. A., Gentry, C., Moss, S., & Bevan, S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5369-07.2008 · Cited by 718
TRPA1 acts as a cold sensor in vitro and in vivo
Karashima, Y., Talavera, K., Everaerts, W., Janssens, A., Kwan, K. Y., Vennekens, R., Nilius, B., & Voets, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808487106 · Cited by 585
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
Meseguer, V., Alpizar, Y. A., Luis, E., Tajada, S., Denlinger, B., Fajardo, O., Manenschijn, J.-A., Fernández-Peña, C., Talavera, A., Kichko, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms4125 · Cited by 479
Eid, S. R., Crown, E. D., Moore, E. L., Liang, H. A., Choong, K.-C., Dima, S., Henze, D. A., Kane, S. A., & Urban, M. O. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-48 · Cited by 447
Metadata
- Authors
- Doerner, J. F., Gisselmann, G., Hatt, H., & Wetzel, C. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 282
- Issue
- 18
- Pages
- 13180-13189
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2000429979
- Cited by
- 320
- References
- 1
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Doerner, J. F., Gisselmann, G., Hatt, H., & Wetzel, C. H. (2007). Transient Receptor Potential Channel A1 Is Directly Gated by Calcium Ions. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m607849200
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