TRP channels as cellular sensors

Clapham, David E.

doi:10.1038/nature02196

Cited by 2,779Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismBiochemical Analysis and Sensing Techniques

TRP channels as cellular sensors

Clapham, David E.·2003·Nature

DOI 10.1038/nature02196

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Abstract

TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.

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GPCRs directly or indirectly modulate several TRP channels.
“GPCRs directly or indirectly modulate several TRP channels [44,45].”
From G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane (2014) · cites this paper as [44]

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Mg2+-dependent Gating and Strong Inward Rectification of the Cation Channel TRPV6
Voets, T., Janssens, A., Prenen, J., Droogmans, G., & Nilius, B. (2003) · The Journal of General Physiology · doi:10.1085/jgp.20028752 · Cited by 155 · see citing works
The transient receptor potential channel on the yeast vacuole is mechanosensitive
Zhou, X., Batiza, A. F., Loukin, S. H., Palmer, C. P., Kung, C., & Saimi, Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1230540100 · Cited by 154 · see citing works
A C. elegans Sperm TRP Protein Required for Sperm-Egg Interactions during Fertilization
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New TRP Channels in Hearing and Mechanosensation
Corey, D. P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00505-1 · Cited by 140 · see citing works
Drosophila mutant with a transducer defect
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Molecular Basis of Amplification in Drosophila Phototransduction
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The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
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CaT1 Contributes to the Stores-operated Calcium Current in Jurkat T-lymphocytes
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A comparison of the genes coding for canonical TRP channels and their M, V and P relatives
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Calmodulin Modulates the Delay Period between Release of Calcium from Internal Stores and Activation of Calcium Influx via Endogenous TRP1 Channels
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Analysis of O-Acetyl-ADP-ribose as a Target for Nudix ADP-ribose Hydrolases
Rafty, L. A., Schmidt, M. T., Perraud, A., Scharenberg, A. M., & Denu, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208997200 · Cited by 60 · see citing works
Biophysical principles of sensory transduction.
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Indications from Mn-quenching of Fura-2 fluorescence in melanotrophs that dopamine and baclofen close Ca channels that are spontaneously open but not those opened by high [K+]o; and that Cd preferentially blocks the latter
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A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S.-H., Tanasă, B., Hogan, P. G., Lewis, R. S., Daly, M. J., & Rao, A. (2006) · Nature · doi:10.1038/nature04702 · Cited by 2,278 · see citing works
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt, S., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. J. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,896 · see citing works
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
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STIM1, an essential and conserved component of store-operated Ca2 + channel function
Roos, J., DiGregorio, P. J., Yeromin, A. V., Ohlsen, K. L., Lioudyno, M., Zhang, S., Safrina, O., Kozak, J. A., Wagner, S. L., Cahalan, M. D., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502019 · Cited by 1,819 · see citing works
AN INTRODUCTION TO TRP CHANNELS
Ramsey, I. S., Delling, M., & Clapham, D. E. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.100431 · Cited by 1,549 · see citing works
Self-citation
Transient Receptor Potential Cation Channels in Disease
Nilius, B., Owsianik, G., Voets, T., & Peters, J. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00021.2006 · Cited by 1,393 · see citing works
TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction
Kwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D.-S., Woolf, C. J., & Corey, D. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.042 · Cited by 1,267 · see citing works
Store-Operated Calcium Channels
Prakriya, M., & Lewis, R. S. (2015) · Physiological Reviews · doi:10.1152/physrev.00020.2014 · Cited by 1,232 · see citing works
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., & Patapoutian, A. (2007) · Nature · doi:10.1038/nature05544 · Cited by 1,112 · see citing works
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
Voets, T., Droogmans, G., Wissenbach, U., Janssens, A., Flockerzi, V., & Nilius, B. (2004) · Nature · doi:10.1038/nature02732 · Cited by 1,060 · see citing works
Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms
Jensen, T. S., & Finnerup, N. B. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70102-4 · Cited by 976 · see citing works
Calcium Absorption Across Epithelia
Hoenderop, J. G. J., Nilius, B., & Bindels, R. J. M. (2004) · Physiological Reviews · doi:10.1152/physrev.00003.2004 · Cited by 933 · see citing works
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
Reiser, J., Polu, K. R., Möller, C., Kenlan, P., Altintas, M. M., Wei, C., Faul, C., Herbert, S., Villegas, I., Ávila-Casado, C., et al. (2005) · Nature Genetics · doi:10.1038/ng1592 · Cited by 852 · see citing works
Self-citation
The cells and logic for mammalian sour taste detection
Huang, A. L., Chen, X., Hoon, M. A., Chandrashekar, J. V., Guo, W., Tränkner, D., Ryba, N. J. P., & Zuker, C. S. (2006) · Nature · doi:10.1038/nature05084 · Cited by 814 · see citing works
Trp ion channels and temperature sensation
Dhaka, A., Viswanath, V., & Patapoutian, A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112958 · Cited by 782 · see citing works
TRP channels: An overview
Pedersen, S. F., Owsianik, G., & Nilius, B. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.028 · Cited by 779 · see citing works
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors
Kobayashi, K., Fukuoka, T., Obata, K., Yamanaka, H., Dai, Y., Tokunaga, A., & Noguchi, K. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20794 · Cited by 766 · see citing works
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
Corey, D. P., Garcı́a-Añoveros, J., Holt, J. R., Kwan, K. Y., Lin, S.-Y., Vollrath, M. A., Amalfitano, A., Cheung, E. L.-M., Derfler, B. H., Duggan, A., et al. (2004) · Nature · doi:10.1038/nature03066 · Cited by 732 · see citing works
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. S. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 667 · see citing works
A possible unifying principle for mechanosensation
Kung, C. (2005) · Nature · doi:10.1038/nature03896 · Cited by 666 · see citing works
TRPC1 forms the stretch-activated cation channel in vertebrate cells
Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Martinac, B., & Hamill, O. P. (2005) · Nature Cell Biology · doi:10.1038/ncb1218 · Cited by 654 · see citing works
Transient receptor potential channels: targeting pain at the source
Patapoutian, A., Tate, S., & Woolf, C. J. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2757 · Cited by 643 · see citing works
The ß-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel
Chang, Q., Hoefs, S. J. G., van der Kemp, A. W., Topala, C. N., Bindels, R. J. M., & Hoenderop, J. G. J. (2005) · Science · doi:10.1126/science.1114245 · Cited by 615 · see citing works
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
Yamamoto, S., Shimizu, S., Kiyonaka, S., Takahashi, N., Wajima, T., Hara, Y., Negoro, T., Hiroi, T., Kiuchi, Y., Okada, T., et al. (2008) · Nature Medicine · doi:10.1038/nm1758 · Cited by 611 · see citing works
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
Rohács, T., Lopes, C. M. B., Michailidis, I. E., & Logothetis, D. E. (2005) · Nature Neuroscience · doi:10.1038/nn1451 · Cited by 593 · see citing works
International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
Wu, L., Sweet, T.-B., & Clapham, D. E. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002725 · Cited by 591 · see citing works
Self-citation
Physiological Diversity in Insects: Ecological and Evolutionary Contexts
Chown, S. L., & Terblanche, J. S. (2006) · Advances in insect physiology · doi:10.1016/s0065-2806(06)33002-0 · Cited by 573 · see citing works
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel
Dong, X., Cheng, X., Mills, E., Delling, M., Wang, F., Kurz, T., & Xu, H. (2008) · Nature · doi:10.1038/nature07311 · Cited by 572 · see citing works
Nitric oxide activates TRP channels by cysteine S-nitrosylation
Yoshida, T., Inoue, R., Morii, T., Takahashi, N., Yamamoto, S., Hara, Y., Tominaga, M., Shimizu, S., Sato, Y., & Mori, Y. (2006) · Nature Chemical Biology · doi:10.1038/nchembio821 · Cited by 566 · see citing works
PERMEATION AND SELECTIVITY OF TRP CHANNELS
Owsianik, G., Talavera, K., Voets, T., & Nilius, B. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.101406 · Cited by 548 · see citing works
TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 548 · see citing works
Transient receptor potential channels as therapeutic targets
Moran, M. M., McAlexander, M. A., Bı́ró, T., & SZALLASI, A. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3456 · Cited by 546 · see citing works
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534 · see citing works
Thermosensation and pain
Tominaga, M., & Caterina, M. J. (2004) · Journal of Neurobiology · doi:10.1002/neu.20079 · Cited by 520 · see citing works
Rapid vesicular translocation and insertion of TRP channels
Bezzerides, V. J., Ramsey, I. S., Kotecha, S. A., Greka, A., & Clapham, D. E. (2004) · Nature Cell Biology · doi:10.1038/ncb1150 · Cited by 520 · see citing works
Self-citation
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
Talavera, K., Yasumatsu, K., Voets, T., Droogmans, G., Shigemura, N., Ninomiya, Y., Margolskee, R. F., & Nilius, B. (2005) · Nature · doi:10.1038/nature04248 · Cited by 517 · see citing works
Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice
Dietrich, A., y Schnitzler, M. M., Gollasch, M., Groß, V., Storch, U., Dubrovska, G., Obst, M., Yildirim, E., Salanova, B., Kalwa, H., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.6980-6989.2005 · Cited by 510 · see citing works
TRP channels in mechanosensation: direct or indirect activation?
Christensen, A. P., & Corey, D. P. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2149 · Cited by 509 · see citing works
The neuronal background K2P channels: focus on TREK1
Honoré, É. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2117 · Cited by 504 · see citing works
Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine
Nilius, B., & SZALLASI, A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008268 · Cited by 504 · see citing works
Multiple roles of phosphoinositide-specific phospholipase C isozymes
Suh, P.-G., Park, J.-I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S.-U., & Ryu, S.-H. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.6.415 · Cited by 501 · see citing works
Direct activation of the ion channel TRPA1 by Ca2+
Zurborg, S., Yurgionas, B., Jira, J. A., Caspani, O., & Heppenstall, P. A. (2007) · Nature Neuroscience · doi:10.1038/nn1843 · Cited by 500 · see citing works
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor
Ishimaru, Y., Inada, H., Kubota, M., Zhuang, H., Tominaga, M., & Matsunami, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602702103 · Cited by 497 · see citing works
Biological effects and medical applications of infrared radiation
Tsai, S.-R., & Hamblin, M. R. (2017) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2017.04.014 · Cited by 497 · see citing works
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis
Yu, F. H., & Catterall, W. A. (2004) · Science s STKE · doi:10.1126/stke.2532004re15 · Cited by 473 · see citing works
The cutaneous sensory system
McGlone, F. P., & Reilly, D. M. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.004 · Cited by 470 · see citing works
Sodium transport in plants: a critical review
Kronzucker, H. J., & Britto, D. T. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03540.x · Cited by 468 · see citing works
TRPM2 activation by cyclic ADP‐ribose at body temperature is involved in insulin secretion
Togashi, K., Hara, Y., Tominaga, T., Higashi, T., Konishi, Y., Mori, Y., & Tominaga, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601083 · Cited by 461 · see citing works
Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1
Groß, O., Yazdi, A. S., Thomas, C. J., Masin, M., Heinz, L. X., Guarda, G., Quadroni, M., Drexler, S. K., & Tschopp, J. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.018 · Cited by 460 · see citing works
TRPA1 is a major oxidant sensor in murine airway sensory neurons
Bessac, B. F., Sivula, M., von Hehn, C. A., Escalera, J., Cohn, L. E., & Jordt, S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34192 · Cited by 451 · see citing works
TRPV4 Forms a Novel Ca 2+ Signaling Complex With Ryanodine Receptors and BK Ca Channels
Earley, S., Heppner, T. J., Nelson, M. T., & Brayden, J. E. (2005) · Circulation Research · doi:10.1161/01.res.0000194321.60300.d6 · Cited by 448 · see citing works
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
Caterina, M. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2006 · Cited by 442 · see citing works
Single-particle cryo-EM—How did it get here and where will it go
Cheng, Y. (2018) · Science · doi:10.1126/science.aat4346 · Cited by 440 · see citing works
Calcium–calcineurin signaling in the regulation of cardiac hypertrophy
Wilkins, B. J., & Molkentin, J. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.121 · Cited by 439 · see citing works
Molecular photoswitches in aqueous environments
Volarić, J., Szymański, W., Simeth, N. A., & Feringa, B. L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00547a · Cited by 439 · see citing works
The Role of Transient Receptor Potential Cation Channels in Ca2+ SignalingPreprint
Gees, M., Colsoul, B., & Nilius, B. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003962 · Cited by 437 · see citing works
Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism
Xu, H., Blair, N. T., & Clapham, D. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2574-05.2005 · Cited by 419 · see citing works
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Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory Neurons and Mediates Inflammatory Heat Hyperalgesia through TRPV1 Sensitization
Zhuang, Z., Xu, H., Clapham, D. E., & Ji, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2893-04.2004 · Cited by 417 · see citing works
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Structure and function of TRPV1
Tominaga, M., & Tominaga, T. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1457-8 · Cited by 414 · see citing works
TRPC3 and TRPC6 are essential for angiotensin II‐induced cardiac hypertrophy
Onohara, N., Nishida, M., Inoue, R., Kobayashi, H., Sumimoto, H., Sato, Y., Mori, Y., Nagao, T., & Kurose, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601417 · Cited by 412 · see citing works
Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals
Tizzano, M., Gulbransen, B. D., Vandenbeuch, A., Clapp, T. R., Herman, J. P., Sibhatu, H. M., Churchill, M. E. A., Silver, W. L., Kinnamon, S. C., & Finger, T. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911934107 · Cited by 409 · see citing works
Critical Role for Transient Receptor Potential Channel TRPM4 in Myogenic Constriction of Cerebral Arteries
Earley, S., Waldron, B. J., & Brayden, J. E. (2004) · Circulation Research · doi:10.1161/01.res.0000147311.54833.03 · Cited by 403 · see citing works
International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
Clapham, D. E., Julius, D. J., Montell, C., & Schultz, G. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.6 · Cited by 385 · see citing works
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The Neuronal Channel NALCN Contributes Resting Sodium Permeability and Is Required for Normal Respiratory Rhythm
Lu, B., Su, Y., Das, S., Liu, J., Xia, J., & Ren, D. (2007) · Cell · doi:10.1016/j.cell.2007.02.041 · Cited by 381 · see citing works
Gq‐coupled receptors as mechanosensors mediating myogenic vasoconstriction
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Functional Characterization of Homo- and Heteromeric Channel Kinases TRPM6 and TRPM7
Li, M., Jiang, J., & Yue, L. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609502 · Cited by 376 · see citing works
Sensing with TRP channels
Voets, T., Talavera, K., Owsianik, G., & Nilius, B. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0705-85 · Cited by 374 · see citing works
Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8
Brauchi, S. E., Orio, P., & Latorre, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406773101 · Cited by 374 · see citing works
Transient receptor potential ( TRP ) channels: a clinical perspective
Kaneko, Y., & SZALLASI, A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 373 · see citing works
Molecular Mechanism of TRP Channels
Zheng, J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c120001 · Cited by 373 · see citing works
Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles
Tykocki, N. R., Boerman, E. M., & Jackson, W. F. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160011 · Cited by 372 · see citing works
Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia
Chubanov, V., Waldegger, S., y Schnitzler, M. M., Vitzthum, H., Sassen, M. C., Seyberth, H. W., Konrad, M., & Gudermann, T. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305252101 · Cited by 371 · see citing works
Frontiers in pruritus research: scratching the brain for more effective itch therapy
Paus, R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28553 · Cited by 368 · see citing works
Tissue Distribution Profiles of the Human TRPM Cation Channel Family
Fonfría, E., Murdock, P. R., Cusdin, F. S., Benham, C. D., Kelsell, R. E., & McNulty, S. (2006) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890600637506 · Cited by 367 · see citing works
Plant Ion Channels: Gene Families, Physiology, and Functional Genomics Analyses
Ward, J. M., Mäser, P., & Schroeder, J. I. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163204 · Cited by 367 · see citing works
Transient Receptor Potential Channels in Cardiovascular Function and Disease
Inoue, R., Jensen, L. J., Shi, J., Morita, H., Nishida, M., Honda, A., & Ito, Y. (2006) · Circulation Research · doi:10.1161/01.res.0000233356.10630.8a · Cited by 366 · see citing works
Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation
Yue, L., Xie, J., & Nattel, S. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq329 · Cited by 362 · see citing works
Calcium Channels in the Development, Maturation, and Function of Spermatozoa
Darszon, A., Nishigaki, T., Beltrán, C., & Treviño, C. L. (2011) · Physiological Reviews · doi:10.1152/physrev.00028.2010 · Cited by 362 · see citing works
TRP channels: Targets for the relief of pain
Levine, J. D., & Alessandri‐Haber, N. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.01.008 · Cited by 360 · see citing works
Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments
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Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain
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Authors: Clapham, D. E.
Affiliations: Boston Children's Hospital (US)
Corresponding author: Clapham, David E.
ORCID: Clapham, David E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-12
Volume: 426
Issue: 6966
Pages: 517-524
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02196
OpenAlex: W2040664792
Cited by: 2,779
References: 100
Citations by year: 2026: 82 · 2025: 85 · 2024: 113 · 2023: 84 · 2022: 129 · 2021: 115 · 2020: 128 · 2019: 120 · 2018: 96 · 2017: 94 · 2016: 120 · 2015: 112 · 2014: 124 · 2013: 117 · 2012: 137
FWCI: 12.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: TRP channels, sensory transduction, temperature sensing, mechanosensing, pain, osmolarity, pheromones, taste, intracellular signaling, ion channels
MeSH terms: Animals, Calcium, Cells, Humans, Models, Biological, Calcium Channels, Signal Transduction, Ion Channel Gating, TRPC Cation Channels

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