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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

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hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

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The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

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Mammalian SIRT1 Represses Forkhead Transcription Factors

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Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity

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AMPK phosphorylates NAMPT to regulate NAD + homeostasis under ionizing radiation

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Nicotinamide Adenine Dinucleotide: The Redox Sensor in Aging-Related Disorders

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Diabetes Mellitus: Channeling Care through Cellular Discovery

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Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design

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Inhibitors of NAD+ Production in Cancer Treatment: State of the Art and Perspectives

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PARP and other prospective targets for poisoning cancer cell metabolism

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NAMPT and NAPRT1: novel polymorphisms and distribution of variants between normal tissues and tumor samples

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Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death

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Regulation of Cancer and Cancer-Related Genes via NAD +

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NAD metabolism and heart failure: Mechanisms and therapeutic potentials

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NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

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Synthesis and Degradation of Adenosine 5′-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases

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The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

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Profiling and annotation of microRNAs and their putative target genes in chilli (Capsicum annuum L.) using ESTs

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Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells

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Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake

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Erratum: Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice.

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NAD+ Precursors and Antioxidants for the Treatment of Amyotrophic Lateral Sclerosis

Obrador, E., Palmer, R. S., López‐Blanch, R., Dellinger, R. W., & Estrela, J. M. (2021) · Biomedicines · doi:10.3390/biomedicines9081000 · Cited by 23

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

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Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.

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Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid

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NAD+-targeting by bacteria: an emerging weapon in pathogenesis

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The Significance of NAD+ Biosynthesis Alterations in Acute Kidney Injury

Clark, A. J., Saadé, M. C., & Parikh, S. M. (2022) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2022.10.013 · Cited by 18

Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry

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Nicotinamide as a Foundation for Treating Neurodegenerative Disease and Metabolic Disorders

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Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling

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Dosing profile profoundly influences nicotinic acid's ability to improve metabolic control in rats

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Niacin prevents mitochondrial oxidative stress caused by sub-chronic exposure to methylmercury

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The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism

Geisler, C. E., Miller, K. E., Ghimire, S., & Renquist, B. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084001 · Cited by 18

Nicotinamide: Oversight of Metabolic Dysfunction Through SIRT1, mTOR, and Clock Genes

Maiese, K. (2020) · Current Neurovascular Research · doi:10.2174/1567202617999201111195232 · Cited by 20

Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy

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Sobriety and Satiety: Is NAD+ the Answer?

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Faculty of Bioscience Engineering

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NAD+ Therapeutics and Skeletal Muscle Adaptation to Exercise in Humans

Campelj, D. G., & Philp, A. (2022) · Sports Medicine · doi:10.1007/s40279-022-01772-2 · Cited by 20

Nicotinic Acid Long-Term Effectiveness in a Patient with Bipolar Type II Disorder: A Case of Vitamin Dependency

Jonsson, B. H. (2018) · Nutrients · doi:10.3390/nu10020134 · Cited by 15

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD+ by Generating Dihydronicotinamide Riboside

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The role of NAD metabolism in neuronal differentiation

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Nicotinamide adenine dinucleotide and the sirtuins caution: Pro‐cancer functions

Palmer, R. D., & Vaccarezza, M. (2021) · Aging Medicine · doi:10.1002/agm2.12184 · Cited by 14

The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD+ Level Is Lower than the Sirtuin-Saturating Concentrations

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Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

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Centrosome Loss Triggers a Transcriptional Program To Counter Apoptosis-Induced Oxidative Stress

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Reducing Oxidative Stress and Enhancing Neurovascular Longevity During Diabetes Mellitus

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Peroxisome proliferator-activated receptor γ coactivator 1α maintains NAD+ bioavailability protecting against steatohepatitis

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Could Exercise Metabolomics Pave the Way for Gymnomimetics?

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A prognostic NAD+ metabolism-related gene signature for predicting response to immune checkpoint inhibitor in glioma

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Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders

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Exosomal NAMPT from chronic lymphocytic leukemia cells orchestrate monocyte survival and phenotype under endoplasmic reticulum stress

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Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4

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Metabolism and Receptor Mechanisms of Niacin Action

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Discrimination of Potent Inhibitors ofToxoplasma gondiiEnoyl-Acyl Carrier Protein Reductase by a Thermal Shift Assay

Afanador, G. A., Muench, S. P., McPhillie, M. J., Fomovska, A., Schön, A., Zhou, Y., Cheng, G., Stec, J., Freundlich, J. S., Shieh, H.-M., et al. (2013) · Biochemistry · doi:10.1021/bi400945y · Cited by 11

β-Nicotinamide Mononucleotide Alleviates Hydrogen Peroxide-Induced Cell Cycle Arrest and Death in Ovarian Granulosa Cells

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DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy

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NAPRT Silencing in FH-Deficient Renal Cell Carcinoma Confers Therapeutic Vulnerabilities via NAD+ Depletion

Noronha, K. J., Lucas, K. N., Paradkar, S., Edmonds, J., Friedman, S., Murray, M. A., Liu, S., Sajed, D. P., Sachs, C. R., Spurrier, J. M., et al. (2024) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-23-1003 · Cited by 9

The nicotinamide phosphoribosyltransferase antagonist FK866 inhibits growth of prostate tumour spheroids and increases doxorubicin retention without changes in drug transporter and cancer stem cell protein expression

Sauer, H., Kampmann, H., Khosravi, F., Sharifpanah, F., & Wartenberg, M. (2020) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13452 · Cited by 8

Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer

Colombo, G., Gelardi, E. L. M., Balestrero, F. C., Moro, M., Travelli, C., & Genazzani, A. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.758320 · Cited by 9

Niacin Status Indicators and Their Relationship with Metabolic Parameters in Dairy Cows during Early Lactation

Petrović, K., Djoković, R., Cincović, M., Hristovska, T., Lalović, M., Petrovic, M. Ž., Majkić, M., Marinković, M. D., Anđušić, L., Devečerski, G., et al. (2022) · Animals · doi:10.3390/ani12121524 · Cited by 9

The Evolutionary Portrait of Metazoan NAD Salvage

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Enhancement by GOSPEL protein of GAPDH aggregation induced by nitric oxide donor and its inhibition by NAD +

González, M. C., Romero, J. M., Ingaramo, M., Sosa, C. J. M., Curtino, J. A., & Carrizo, M. E. (2016) · FEBS Letters · doi:10.1002/1873-3468.12242 · Cited by 8

Formation of [Nicotinamide-2H3]NAD+ from [2H4]Nicotinamide and [2H4]Nicotinic Acid in Human HepG2N Cells and Involvement of 2H/1H Exchange at the Redox Site of NAD+/NADH

Hara, N., Shibata, T., Osago, H., Yamada, K., & Tsuchiya, M. (2014) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.60.17 · Cited by 8

NAD+ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma

Soncini, D., Becherini, P., Ladisa, F., Ravera, S., Chedere, A., Gelli, E., Giorgetti, G., Martinuzzi, C., Piacente, F., Mastracci, L., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013425 · Cited by 7

Sirtuins in metabolic disease: innovative therapeutic strategies with SIRT1, AMPK, mTOR, and nicotinamide

Maiese, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822467-0.00006-1 · Cited by 9

Niacin alleviates extracellular matrix deposition in ethanol + CCl4-induced liver fibrosis through the HSP90/JAK1/STAT3 axis

Fan, Y., Xue, M., Shan, T., Bai, Y., Zhang, H., Liu, M., Wang, P., Liang, X., & Liang, H. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103454 · Cited by 6

Distinct Capabilities in NAD Metabolism Mediate Resistance to NAMPT Inhibition in Glioblastoma

Perryman, R., Chau, T. W., DeFelice, J., O’Neill, K., & Syed, N. (2024) · Cancers · doi:10.3390/cancers16112054 · Cited by 6

NAPRT, but Not NAMPT, Provides Additional Support for NAD Synthesis in Esophageal Precancerous Lesions

Wang, N., Pan, D., Wang, X., Su, M., Wang, X., Yan, Q., Sun, G., & Wang, S. (2022) · Nutrients · doi:10.3390/nu14224916 · Cited by 5

A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase

Minazzato, G., Marangoni, E., Fortunato, C., Petrelli, R., Cappellacci, L., Bello, F. D., Sorci, L., Gasparrini, M., Piacente, F., Bruzzone, S., et al. (2023) · Molecules · doi:10.3390/molecules28030961 · Cited by 5

A Photoactivated Ru (II) Polypyridine Complex Induced Oncotic Necrosis of A549 Cells by Activating Oxidative Phosphorylation and Inhibiting DNA Synthesis as Revealed by Quantitative Proteomics

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Probing the Druggability Limits for Enzymes of the NAD Biosynthetic Network in Glioma

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Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators

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Nicotinic acid improves mitochondrial function and associated transcriptional pathways in older inactive males

Deane, C. S., Willis, C. R. G., Gallagher, I. J., Brook, M. S., Gharahdaghi, N., Wylie, L. J., Wilkinson, D. J., Smith, K. E., Atherton, P. J., & Etheridge, T. (2024) · Translational Exercise Biomedicine · doi:10.1515/teb-2024-0030 · Cited by 4

Isolation and Characterization of the Anticancer Gene Organic Cation Transporter Like-3 (ORCTL3)

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Resveratrol and Quercetin Potentiate the Cell Protection and Rescue Effects of NAD + Precursors in HEK293 Cells Challenged by DNA Damaging Agent, N -Methyl- N′ -nitro- N -nitrosoguanidine

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Supplementation of Nicotinic Acid and Its Derivatives Up-Regulates Cellular NAD+ Level Rather than Nicotinamide Derivatives in Cultured Normal Human Epidermal Keratinocytes

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Metabolic Alterations in NADSYN1-Deficient Cells

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Exploring mitonuclear interactions in the regulation of cell physiology: Insights from interspecies cybrids

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Pharmacological Nicotinamide: Mechanisms Centered Around SIRT1 Activity

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Medwakh smoking induces alterations in salivary proteins and cytokine expression: a clinical exploratory proteomics investigation

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Polysaccharides from Baihe Dihuang decoction ameliorate depression-like behaviors in rats subjected to chronic unpredictable mild stress through modulation of metabolic homeostasis

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NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis

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Additional file 1 of NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

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Additional file 3 of NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

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Additional file 2 of NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

Joo, H.-Y., Jung, J. K., Kim, M.-Y., Woo, S. R., Jeong, J. M., Park, E.-R., Kim, Y.-M., Park, J., Kim, J., Yun, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24225253

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