Cited by 206Sirtuins and Resveratrol in MedicineBiochemical and Molecular ResearchFolate and B Vitamins Research

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Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human Cells

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Hara, Nobumasa, Yamada, Kazuo, Shibata, Tomoko, Osago, Harumi, Hashimoto, Tatsuya, Tsuchiya, Mikako·2007·Journal of Biological Chemistry

DOI 10.1074/jbc.m610357200

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Abstract

NAD plays critical roles in various biological processes through the function of SIRT1. Although classical studies in mammals showed that nicotinic acid (NA) is a better precursor than nicotinamide (Nam) in elevating tissue NAD levels, molecular details of NAD synthesis from NA remain largely unknown. We here identified NA phosphoribosyltransferase (NAPRT) in humans and provided direct evidence of tight link between NAPRT and the increase in cellular NAD levels. The enzyme was abundantly expressed in the small intestine, liver, and kidney in mice and mediated [(14)C]NAD synthesis from [(14)C]NA in human cells. In cells expressing endogenous NAPRT, the addition of NA but not Nam almost doubled cellular NAD contents and decreased cytotoxicity by H(2)O(2). Both effects were reversed by knockdown of NAPRT expression. These results indicate that NAPRT is essential for NA to increase cellular NAD levels and, thus, to prevent oxidative stress of the cells. Kinetic analyses revealed that NAPRT, but not Nam phosphoribosyltransferase (NamPRT, also known as pre-B-cell colony-enhancing factor or visfatin), is insensitive to the physiological concentration of NAD. Together, we conclude that NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD. The ability of NA to increase cellular NAD contents may account for some of the clinically observed effects of the vitamin and further implies a novel application of the vitamin to treat diseases such as those associated with the depletion of cellular NAD pools.

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Authors: Hara, N., Yamada, K., Shibata, T., Osago, H., Hashimoto, T., & Tsuchiya, M.
Affiliations: Shimane University (JP)
Corresponding author: Hara, Nobumasa
ORCID: Hara, Nobumasa
Yamada, Kazuo
Osago, Harumi
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2007-08
Volume: 282
Issue: 34
Pages: 24574-24582
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m610357200
OpenAlex: W2083287520
Cited by: 205
References: 46
Citations by year: 2026: 3 · 2025: 7 · 2024: 15 · 2023: 14 · 2022: 23 · 2021: 15 · 2020: 11 · 2019: 7 · 2018: 16 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 4
FWCI: 4.80
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4825 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Keywords: nicotinic acid, NAD levels, visfatin, NAD biosynthesis, SIRT1, oxidative stress, hydrogen peroxide cytotoxicity, nicotinamide
MeSH terms: Animals, HeLa Cells, Humans, Kinetics, Mice, Inbred BALB C, Models, Biological, Molecular Sequence Data, NAD, Niacin, Pentosyltransferases, Tissue Distribution, Oxidative Stress, RNA, Small Interfering, Mice, Rats

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Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human Cells

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