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CatSperβ, a Novel Transmembrane Protein in the CatSper Channel Complex
Open accessAbstract
Four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. We set out to identify proteins associating with CatSper that might help explain its unique role in spermatozoa. Using a transgenic approach, a CatSper1 complex was purified from mouse testis that contained heat shock protein 70-2, a testis-specific chaperone, and CatSperbeta, a novel protein with two putative transmembrane-spanning domains. Like the CatSper ion channel subunits, CatSperbeta was restricted to testis and localized to the principal piece of the sperm tail. CatSperbeta protein is absent in CatSper1(-/-) sperm, suggesting that it is required for trafficking or formation of a stable channel complex. CatSperbeta is the first identified auxiliary protein to the CatSper channel.
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Citations
Cited by
Progesterone activates the principal Ca2+ channel of human sperm
Lishko, P. V., Botchkina, I. L., & Kirichok, Y. (2011) · Nature · doi:10.1038/nature09767 · Cited by 615
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels
Alexander, S. P. H., Mathie, A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14749 · Cited by 606
Calcium Channels in the Development, Maturation, and Function of Spermatozoa
Darszon, A., Nishigaki, T., Beltran, C., & Treviño, C. L. (2011) · Physiological Reviews · doi:10.1152/physrev.00028.2010 · Cited by 364
Ion channels, phosphorylation and mammalian sperm capacitation
Visconti, P. E., Krapf, D., de la Vega-Beltrán, J. L., Acevedo, J. J., & Darszon, A. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2010.69 · Cited by 327
Ca2+-Activated K+Channels: From Protein Complexes to Function
Berkefeld, H., Fakler, B., & Schulte, U. (2010) · Physiological Reviews · doi:10.1152/physrev.00049.2009 · Cited by 274
Metadata
- Authors
- Liu, J., Xia, J., Cho, K.-H., Clapham, D. E., & Ren, D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 282
- Issue
- 26
- Pages
- 18945-18952
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1985666187
- Cited by
- 167
- References
- 0
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Liu, J., Xia, J., Cho, K.-H., Clapham, D. E., & Ren, D. (2007). CatSperβ, a Novel Transmembrane Protein in the CatSper Channel Complex. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m701083200
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
