The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3
Open accessAbstract
Atg4C/autophagin-3 is a member of a family of cysteine proteinases proposed to be involved in the processing and delipidation of the mammalian orthologues of yeast Atg8, an essential component of an ubiquitin-like modification system required for execution of autophagy. To date, the in vivo role of the different members of this family of proteinases remains unclear. To gain further insights into the functional relevance of Atg4 orthologues, we have generated mutant mice deficient in Atg4C/autophagin-3. These mice are viable and fertile and do not display any obvious abnormalities, indicating that they are able to develop the autophagic response required during the early neonatal period. However, Atg4C-/--starved mice show a decreased autophagic activity in the diaphragm as assessed by immunoblotting studies and by fluorescence microscopic analysis of samples from Atg4C-/- GFP-LC3 transgenic mice. In addition, animals deficient in Atg4C show an increased susceptibility to develop fibrosarcomas induced by chemical carcinogens. Based on these results, we propose that Atg4C is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation. We also propose that this enzyme could play an in vivo role in events associated with tumor progression.
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Cites
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DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
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Cited by
Autophagy in the Pathogenesis of Disease
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Autophagy fights disease through cellular self-digestion
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Self-citationMethods in Mammalian Autophagy Research
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Self-citationmTOR: from growth signal integration to cancer, diabetes and ageing
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Autophagy in Human Health and Disease
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Metadata
- Authors
- Mariño, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N., & López-Otín, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 282
- Issue
- 25
- Pages
- 18573-18583
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2155452700
- Cited by
- 407
- References
- 11
- FWCI
- 16.12
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- hybrid
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- Mariño, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N., & López-Otín, C. (2007). Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m701194200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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