The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hepatic CTP:Phosphocholine Cytidylyltransferase-α Is a Critical Predictor of Plasma High Density Lipoprotein and Very Low Density Lipoprotein
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When HDL generation by ABCA1 transporters at hepatocytes is compromised, VLDL secretion is rapidly reversed due to elevated triacylglycerol biogeneration in the liver.
“It is thought that when HDL generation by ABCA1 transporters at hepatocytes is compromised, VLDL secretion is rapidly reversed due to elevated triacylglycerol biogeneration in the liver.22–26”
From Clinical diversity and molecular mechanism of VPS35L-associated Ritscher-Schinzel syndrome (2023) · cites this paper as [25]
The Results section (‘VLDL Secretion Is Impaired in CTα-deficient Hepatocytes’; page unavailable) reports both diminished VLDL secretion and increased intracellular triacylglycerol in cells with impaired HDL-related lipid efflux. It does not say that increased triacylglycerol production rapidly reverses VLDL secretion: the Discussion says short-term restoration of phosphatidylcholine synthesis did not restore secretion and suggests that recovery may require an extended period. (LLM, conf=0.86)
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Timmins, J. M., Lee, J.-Y., Boudyguina, E., Kluckman, K. D., Brunham, L. R., Mulya, A., Gebre, A. K., Coutinho, J. M., Colvin, P. L., Smith, T. L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23915 · Cited by 447
Fast, D. G., & Vance, D. E. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00116-t · Cited by 77
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Cited by
Sorted by citations
Insulin Regulation of Hepatic Lipid Homeostasis
Uehara, K., Santoleri, D., Whitlock, A. E. G., & Titchenell, P. M. (2023) · Comprehensive Physiology · doi:10.1002/cphy.c220015 · Cited by 49
Clinical diversity and molecular mechanism of VPS35L-associated Ritscher-Schinzel syndrome
Otsuji, S., Nishio, Y., Tsujita, M., Rio, M., Huber, C., Antón-Plágaro, C., Mizuno, S., Kawano, Y., Miyatake, S., Simon, M., et al. (2023) · Journal of Medical Genetics · doi:10.1136/jmg-2022-108602 · Cited by 19
Metadata
- Authors
- Jacobs, R. L., Lingrell, S., Zhao, Y., Francis, G. A., & Vance, D. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 283
- Issue
- 4
- Pages
- 2147-2155
- ISSN
- 0021-9258
- Cited by
- 79
- References
- 3
- Language
- en
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