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TINY, a Dehydration-responsive Element (DRE)-binding Protein-like Transcription Factor Connecting the DRE- and Ethylene-responsive Element-mediated Signaling Pathways in Arabidopsis
Open accessAbstract
Dehydration-responsive element-binding proteins (DREBs) and ethylene-responsive element (ERE) binding factors are two major subfamilies of the AP2/ethylene-responsive element-binding protein family and play crucial roles in the regulation of abiotic- and biotic-stress responses, respectively. In the present work, we have reported a previously identified DREB-like factor, TINY, that was involved in both abiotic- and biotic-stress signaling pathways. TINY was capable of binding to both DRE and ERE with similar affinity and could activate the expression of reporter genes driven by either of these two elements in tobacco cells. The 15th amino acid in the APETALA2 (AP2)/ethylene-responsive element-binding factor domain was demonstrated to be essential for its specific binding to ERE, whereas the 14th and 19th amino acids were responsible for the binding to DRE. The expression of TINY was greatly activated by drought, cold, ethylene, and slightly by methyl jasmonate. Additionally, overexpression of TINY in Arabidopsis resulted in elevated expressions of both the DRE- and the ERE-containing genes. Moreover, the expression of DRE-regulated genes, such as COR6.6 and ERD10, was up-regulated upon ethylene treatment, and the expression of ERE-regulated genes, such as HLS1, was also increased by cold stress, when the expression of TINY was being induced. These results strongly suggested that TINY might play a role in the cross-talk between abiotic- and biotic-stress-responsive gene expressions by connecting the DRE- and ERE-mediated signaling pathways. The results herein might promote the understanding of the mechanisms of specific DNA recognition and gene expression regulation by DREBs.
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Metadata
- Authors
- Sun, S., Yu, J.-P., Chen, F., Zhao, T.-J., Fang, X.-H., Li, Y.-Q., & Sui, S.-F.
- Affiliations
- Tsinghua University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Sui, Sen-Fang
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 283
- Issue
- 10
- Pages
- 6261-6271
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2002771652
- Cited by
- 187
- References
- 46
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 24 · 2023: 3 · 2022: 16 · 2021: 5 · 2020: 13 · 2019: 10 · 2018: 4 · 2017: 11 · 2016: 9 · 2015: 13 · 2014: 6 · 2013: 15 · 2012: 9
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Keywords
- dehydration-responsive element, AP2/ERF family, abiotic stress signaling, stress-responsive gene expression, drought stress, cold stress, ethylene signaling, methyl jasmonate, DNA binding specificity, Arabidopsis thaliana
- MeSH terms
- Acetates, Cold Temperature, Cyclopentanes, Dehydration, Disasters, Ethylenes, Nuclear Proteins, Plant Growth Regulators, Signal Transduction, Arabidopsis, Protein Structure, Tertiary, Homeodomain Proteins, Gene Expression Regulation, Plant, Response Elements, Arabidopsis Proteins, Oxylipins
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- CoChat. (2026). Citation check: TINY, a Dehydration-responsive Element (DRE)-binding Protein-like Transcription Factor Connecting the DRE- and Ethylene-responsive Element-mediated Signaling Pathways in Arabidopsis. https://app.cochat.ai/papers/10.1074/jbc.m706800200
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- Sun, S., Yu, J.-P., Chen, F., Zhao, T.-J., Fang, X.-H., Li, Y.-Q., & Sui, S.-F. (2008). TINY, a Dehydration-responsive Element (DRE)-binding Protein-like Transcription Factor Connecting the DRE- and Ethylene-responsive Element-mediated Signaling Pathways in Arabidopsis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m706800200
