The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells
Open accessAbstract
Targeting TRAIL receptors with either recombinant TRAIL or agonistic DR4- or DR5-specific antibodies has been considered a promising treatment for cancer, particularly due to the preferential apoptotic susceptibility of tumor cells over normal cells to TRAIL. However, the realization that many tumors are unresponsive to TRAIL treatment has stimulated interest in identifying apoptotic agents that when used in combination with TRAIL can sensitize tumor cells to TRAIL-mediated apoptosis. Our studies suggest that various apoptosis defects that block TRAIL-mediated cell death at different points along the apoptotic signaling pathway shift the signaling cascade from default apoptosis toward cytoprotective autophagy. We also obtained evidence that inhibition of such a TRAIL-mediated autophagic response by specific knockdown of autophagic genes initiates an effective mitochondrial apoptotic response that is caspase-8-dependent. Currently, the molecular mechanisms linking disabled autophagy to mitochondrial apoptosis are not known. Our analysis of the molecular mechanisms involved in the shift from protective autophagy to apoptosis in response to TRAIL sheds new light on the negative regulation of apoptosis by the autophagic process and by some of its individual components.
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Cites
How to Interpret LC3 Immunoblotting
Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,669
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
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Self-citationGrowth factor regulation of autophagy and cell survival in the absence of apoptosis
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Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C. B., & Tsujimoto, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1192 · Cited by 1,358
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108
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Anoikis molecular pathways and its role in cancer progression
Paoli, P., Giannoni, E., & Chiarugi, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.026 · Cited by 1,160
HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
Tang, D., Kang, R., Cheh, C.-W., Livesey, K. M., Liang, X., Schapiro, N. E., Benschop, R., Sparvero, L. J., Amoscato, A. A., Tracey, K. J., et al. (2010) · Oncogene · doi:10.1038/onc.2010.261 · Cited by 461
TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells
Herrero‐Martín, G., Høyer‐Hansen, M., García‐García, C., Fumarola, C., Farkas, T., López‐Rivas, A., & Jäättelä, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.8 · Cited by 400
Role and regulation of autophagy in cancer
Chen, N., & Karantza-Wadsworth, V. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.12.013 · Cited by 357
Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport
Han, J., Goldstein, L. A., Hou, W., Watkins, S. C., & Rabinowich, H. (2021) · Autophagy · doi:10.1080/15548627.2020.1761742 · Cited by 20
Self-citation
Metadata
- Authors
- Han, J., Hou, W., Goldstein, L. A., Lu, C., Stolz, D. B., Yin, X.-M., & Rabinowich, H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 283
- Issue
- 28
- Pages
- 19665-19677
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2011776457
- Cited by
- 181
- References
- 5
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Han, J., Hou, W., Goldstein, L. A., Lu, C., Stolz, D. B., Yin, X.-M., & Rabinowich, H. (2008). Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m710169200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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