Anoikis molecular pathways and its role in cancer progression

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Regulation of cancer cell metabolism

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Caspases: the executioners of apoptosis

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Geometric Control of Cell Life and Death

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Complex networks orchestrate epithelial–mesenchymal transitions

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Integrin signaling

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Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

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Mitochondrial membrane permeabilization in cell death

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

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Disruption of epithelial cell-matrix interactions induces apoptosis

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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

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Epidermal growth factor receptor mutations in lung cancer

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Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

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Regulation of Cell Death Protease Caspase-9 by Phosphorylation

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Two CD95 (APO‐1/Fas) signaling pathways

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NF-κB at the crossroads of life and death

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Apoptosis: controlled demolition at the cellular level

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NF-κB in cancer: from innocent bystander to major culprit

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

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Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

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mTOR regulation of autophagy

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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

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Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

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NF-κB is a target of AKT in anti-apoptotic PDGF signalling

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Redox regulation of cell survival

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Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1

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BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

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Hypoxia, HIF1 and glucose metabolism in the solid tumour

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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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p53 Regulates Mitochondrial Respiration

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Inhibition of Macroautophagy Triggers Apoptosis

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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

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Targeting microRNAs in cancer: rationale, strategies and challenges

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Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

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Akt Stimulates Aerobic Glycolysis in Cancer Cells

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RHO–GTPases and cancer

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The Snail genes as inducers of cell movement and survival: implications in development and cancer

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Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

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Perturbations of the AKT signaling pathway in human cancer

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Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

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Anoikis mechanisms

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Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

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BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly

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Signaling through focal adhesion kinase

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Integrins and anoikis

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AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

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Control of adhesion-dependent cell survival by focal adhesion kinase.

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The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway

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NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

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An Induced Proximity Model for Caspase-8 Activation

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Tyrosine Phosphorylation of Focal Adhesion Kinase at Sites in the Catalytic Domain Regulates Kinase Activity: a Role for Src Family Kinases

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The seed and soil hypothesis revisited—The role of tumor‐stroma interactions in metastasis to different organs

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The Fas Signaling Pathway: More Than a Paradigm

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Src family kinases, key regulators of signal transduction

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Regulation of PTEN Transcription by p53

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Nox proteins in signal transduction

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Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

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Cell migration in tumors

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Regulation of glut1 mRNA by Hypoxia-inducible Factor-1

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E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

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Anoikis: an emerging hallmark in health and diseases

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A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

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Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

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MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA

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Prespecification and plasticity: shifting mechanisms of cell migration

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14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

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hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

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Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

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Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

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NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4

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The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

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The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

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The interplay between MYC and HIF in cancer

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Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

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Anoikis

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Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness

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Malignant cells facilitate lung metastasis by bringing their own soil

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Integrin-linked kinase: a cancer therapeutic target unique among its ILK

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Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion‐dependent cell survival

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Biochemical signals and biological responses elicited by the focal adhesion kinase

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Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

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Molecular mechanisms of “detachment-induced apoptosis—Anoikis”

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Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

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Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

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