Msx2 Exerts Bone Anabolism via Canonical Wnt Signaling

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,015 · see citing works

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

Sacchetti, B., Funari, A., Michienzi, S., Di Cesare, S., Piersanti, S., Saggio, I., Tagliafico, E., Ferrari, S., Robey, P. G., Riminucci, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.025 · Cited by 2,226 · see citing works

Inhibition of Adipogenesis by Wnt Signaling

Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876 · see citing works

Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis

Chai, Y., Jiang, X., Ito, Y., Bringas, P., Han, J., Rowitch, D. H., Soriano, P. M., McMahon, A. P., & Sucov, H. M. (2000) · Development · doi:10.1242/dev.127.8.1671 · Cited by 1,464 · see citing works

Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression

Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170 · see citing works

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

(2018) · Wiley eBooks · doi:10.1002/9781119266594 · Cited by 1,103 · see citing works

An LDL-receptor-related protein mediates Wnt signalling in mice

Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086 · see citing works

Quantification of Bone Microarchitecture with the Structure Model Index

Hildebrand, T., & Ruegsegger, P. (1997) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/01495739708936692 · Cited by 1,053 · see citing works

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995 · see citing works

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.

Ory, D., Neugeboren, B. I., & Mulligan, R. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11400 · Cited by 926 · see citing works

Regulation of osteoblastogenesis and bone mass by Wnt10b

Bennett, C. N., Longo, K. A., Hahn, W. S., Suva, L. J., Lane, T. F., Hankenson, K. D., & MacDougald, O. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408742102 · Cited by 882 · see citing works

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

Zhou, Z., Apte, S., Soininen, R., Cao, R., Baaklini, G. Y., Rauser, R. W., Wang, J., Cao, Y., & Tryggvason, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.060037197 · Cited by 791 · see citing works

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., et al. (2000) · Nature Genetics · doi:10.1038/74231 · Cited by 737 · see citing works

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005) · Development · doi:10.1242/dev.01564 · Cited by 682 · see citing works

A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis

Jabs, E. W., Müller, U., Li, X., Ma, L., Luo, W., Haworth, I. S., Klisak, I. J., Sparkes, R. S., Warman, M. L., Mulliken, J. B., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90379-5 · Cited by 673 · see citing works

LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors

Mani, A., Radhakrishnan, J., Wang, H., Mani, A., Mani, M.-A., Nelson-Williams, C. J., Carew, K. S., Mane, S., Najmabadi, H., Wu, D., et al. (2007) · Science · doi:10.1126/science.1136370 · Cited by 587 · see citing works

The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

Nissen, R. M., & Yamamoto, K. R. (2000) · Genes & Development · doi:10.1101/gad.827900 · Cited by 559 · see citing works

Osteo/Chondrocytic Transcription Factors and Their Target Genes Exhibit Distinct Patterns of Expression in Human Arterial Calcification

Tyson, K. L., Reynolds, J. L., McNair, R., Zhang, Q., Weissberg, P. L., & Shanahan, C. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000059406.92165.31 · Cited by 523 · see citing works

Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass

Morvan, F., Boulukos, K. E., Clément-Lacroix, P., Roman‐Roman, S., Suc-Royer, I., Vayssière, B., Ammann, P., Martin, P., Pinho, S., Pognonec, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060311 · Cited by 521 · see citing works

Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

Clément-Lacroix, P., Ai, M., Morvan, F., Roman‐Roman, S., Vayssière, B., Belleville, C., Estrera, K. A., Warman, M. L., Baron, R., & Rawadi, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505259102 · Cited by 520 · see citing works

Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals

Shao, J.-S., Cheng, S., Pingsterhaus, J. M., Charlton-Kachigian, N., Loewy, A. P., & Towler, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24140 · Cited by 452 · see citing works

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

Li, J., Sarosi, I., Cattley, R. C., Pretorius, J. K., Asuncion, F., Grisanti, M. S., Morony, S., Adamu, S., Geng, Z., Qiu, W., et al. (2006) · Bone · doi:10.1016/j.bone.2006.03.017 · Cited by 441 · see citing works

Human Degenerative Valve Disease Is Associated With Up-Regulation of Low-Density Lipoprotein Receptor-Related Protein 5 Receptor-Mediated Bone Formation

Caira, F. C., Stock, S. R., Gleason, T. G., McGee, E. C., Huang, J., Bonow, R. O., Spelsberg, T. C., McCarthy, P. M., Rahimtoola, S. H., & Rajamannan, N. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.02.040 · Cited by 371 · see citing works

Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6

Holmen, S. L., Giambernardi, T. A., Diegel, C. R., Buckner-Berghuis, B. D., Resau, J. H., Hess, J. F., Glatt, V., Bouxsein, M., Ai, M., Warman, M. L., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040907 · Cited by 344 · see citing works

Msx2 Promotes Osteogenesis and Suppresses Adipogenic Differentiation of Multipotent Mesenchymal Progenitors

Cheng, S., Shao, J.-S., Charlton-Kachigian, N., Loewy, A. P., & Towler, D. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306972200 · Cited by 332 · see citing works

Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation

Tu, X., Joeng, K. S., Nakayama, K., Nakayama, K., Rajagopal, J., Carroll, T. J., McMahon, A. P., & Long, F. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.11.003 · Cited by 314 · see citing works

Aortic Msx2-Wnt Calcification Cascade Is Regulated by TNF-α–Dependent Signals in Diabetic Ldlr −/− Mice

Al‐Aly, Z., Shao, J.-S., Lai, C., Huang, E., Cai, J., Behrmann, A., Cheng, S., & Towler, D. A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.153668 · Cited by 307 · see citing works

Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass

Gowen, L. C., Petersen, D. N., Mansolf, A. L., Qi, H., Stock, J. L., Tkalcevic, G. T., Simmons, H. A., Crawford, D. T., Chidsey-Frink, K. L., Ke, H. Z., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m203250200 · Cited by 295 · see citing works

Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape

MacKenzie, A., Ferguson, M. W. J., & Sharpe, P. T. (1992) · Development · doi:10.1242/dev.115.2.403 · Cited by 294 · see citing works

Dlx3 Transcriptional Regulation of Osteoblast Differentiation: Temporal Recruitment of Msx2, Dlx3, and Dlx5 Homeodomain Proteins to Chromatin of the Osteocalcin Gene

Hassan, M. Q., Javed, A., Morasso, M. I., Karlin, J., Montecino, M. A., van Wijnen, A. J., Stein, G. S., Stein, J. L., & Lian, J. B. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9248-9261.2004 · Cited by 285 · see citing works

Deletion of the P2X7Nucleotide Receptor Reveals Its Regulatory Roles in Bone Formation and Resorption

Ke, H. Z., Qi, H., Weidema, A. F., Zhang, Q. H., Panupinthu, N., Crawford, D. T., GRASSER, W. A., Paralkar, V. M., Li, M., Audoly, L., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0021 · Cited by 283 · see citing works

Heterodimerization of Msx and Dlx Homeoproteins Results in Functional Antagonism

Zhang, H., Hu, G., Wang, H., Sciavolino, P. J., Iler, N., Shen, M. M., & Abate-Shen, C. T. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2920 · Cited by 262 · see citing works

Bone histomorphometry

Anderson, C. (1994) · Bone and Mineral · doi:10.1016/s0169-6009(08)80063-3 · Cited by 258 · see citing works

Diet-induced Diabetes Activates an Osteogenic Gene Regulatory Program in the Aortas of Low Density Lipoprotein Receptor-deficient Mice

Towler, D. A., Bidder, M., Latifi, T. N., Coleman, T., & Semenkovich, C. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30427 · Cited by 246 · see citing works

Growing C57Bl/6 Mice Increase Whole Bone Mechanical Properties by Increasing Geometric and Material Properties

Brodt, M. D., Ellis, C. B., & Silva, M. J. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.12.2159 · Cited by 232 · see citing works

Premature suture closure and ectopic cranial bone in mice expressing Msx2 transgenes in the developing skull.

Liu, Y. H., Kundu, R. K., Wu, L., Luo, W., Ignelzi, M. A., Snead, M. L., & Maxson, R. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.6137 · Cited by 222 · see citing works

BMP2 Commitment to the Osteogenic Lineage Involves Activation of Runx2 by DLX3 and a Homeodomain Transcriptional Network

Hassan, M. Q., Tare, R. S., Lee, S. H., Mandeville, M., Morasso, M. I., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., & Lian, J. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604508200 · Cited by 221 · see citing works

Dmp1-deficient Mice Display Severe Defects in Cartilage Formation Responsible for a Chondrodysplasia-like Phenotype

Ye, L., Mishina, Y. M., Chen, D., Huang, H., Dallas, S. L., Dallas, M. R., Sivakumar, P., Kunieda, T., Tsutsui, T. W., Boskey, A. L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412911200 · Cited by 214 · see citing works

Differential Regulation of the Two Principal Runx2/Cbfa1 N-Terminal Isoforms in Response to Bone Morphogenetic Protein-2 during Development of the Osteoblast Phenotype

Banerjee, C., Javed, A., Choi, J., Green, J., Rosen, V., van Wijnen, A. J., Stein, J. L., Lian, J. B., & Stein, G. S. (2001) · Endocrinology · doi:10.1210/endo.142.9.8367 · Cited by 206 · see citing works

Msx2Gene Dosage Influences the Number of Proliferative Osteogenic Cells in Growth Centers of the Developing Murine Skull: A Possible Mechanism forMSX2-Mediated Craniosynostosis in Humans

Liu, Y., Tang, Z., Kundu, R. K., Wu, L., Luo, W., Zhu, D., Sangiorgi, F. O., Snead, M. L., & Maxson, R. E. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9114 · Cited by 201 · see citing works

Dlx5 Specifically Regulates Runx2 Type II Expression by Binding to Homeodomain-response Elements in the Runx2 Distal Promoter

Lee, M., Kim, Y.-J., Yoon, W., Kim, J.-I., Kim, B.-G., Hwang, Y., Wozney, J. M., Chi, X., Bae, S., Choi, K., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502267200 · Cited by 198 · see citing works

Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells.

Barnes, G. B., Javed, A., Waller, S. M., Kamal, M. H., Hebert, K. E., Hassan, M. Q., Bellahcène, A., van Wijnen, A. J., Young, M. F., Lian, J. B., et al. (2003) · PubMed · Cited by 188 · see citing works

Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5

Shirakabe, K., Terasawa, K., Miyama, K., Shibuyà, H., & Nishida, E. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00466.x · Cited by 177 · see citing works

Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice.

Shao, J.-S., Cheng, S.-L., Charlton-Kachigian, N., Loewy, A. P., & Towler, D. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308825200 · Cited by 174 · see citing works

The molecular basis of Boston-type craniosynostosis: the Pro148-->His mutation in the N-terminal arm of the MSX2 homeodomain stabilizes DNA binding without altering nucleotide sequence preferences

Ma, L. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.12.1915 · Cited by 174 · see citing works

Reciprocal Roles of Msx2 in Regulation of Osteoblast and Adipocyte Differentiation

Ichida, F., Nishimura, R., Hata, K., Matsubara, T., Ikeda, F., Hisada, K., Yatani, H., Cao, X., Komori, T., Yamaguchi, A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403621200 · Cited by 173 · see citing works

Bone mass is inversely proportional to Dkk1 levels in mice

MacDonald, B. T., Joiner, D. M., Oyserman, S. M., Sharma, P., Goldstein, S. A., He, X., & Hauschka, P. V. (2007) · Bone · doi:10.1016/j.bone.2007.05.009 · Cited by 169 · see citing works

Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation

VanHouten, J. N., Dann, P. R., Stewart, A. F., Watson, C. J., Pollak, M., Karaplis, A. C., & Wysolmerski, J. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319504 · Cited by 169 · see citing works

Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells

Jackson, A. M., Vayssière, B., Garcia, T., Newell, W., Baron, R., Roman‐Roman, S., & Rawadi, G. (2005) · Bone · doi:10.1016/j.bone.2005.01.007 · Cited by 166 · see citing works

Remodeling and Vascular Spaces in Bone

Eriksen, E. F., Eghbali-Fatourechi, G. Z., & Khosla, S. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060910 · Cited by 158 · see citing works

Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation

VanHouten, J. N., Dann, P. R., Stewart, A. F., Watson, C. J., Pollak, M., Karaplis, A. C., & Wysolmerski, J. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19504 · Cited by 151 · see citing works

Functional Characterization of WNT7A Signaling in PC12 Cells

Caricasole, A., Ferraro, T., Iacovelli, L., Barletta, E., Caruso, A., Melchiorri, D., Terstappen, G. C., & Nicoletti, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300191200 · Cited by 142 · see citing works

Reciprocal Regulation of Osteocalcin Transcription by the Homeodomain Proteins Msx2 and Dlx5

Newberry, E. P., Latifi, T. N., & Towler, D. A. (1998) · Biochemistry · doi:10.1021/bi981878u · Cited by 141 · see citing works

In Vitro andIn Vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene

Cheng, S.-L., Lou, J., Wright, N. M., et al. (2001) · Calcified Tissue International · doi:10.1007/bf02678146 · Cited by 138 · see citing works

Msx-2/Hox 8.1: a transcriptional regulator of the rat osteocalcin promoter.

Towler, D. A., Rutledge, S. J., & Rodan, G. A. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.11.7877617 · Cited by 137 · see citing works

Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins.

Hoffmann, H. M., Catron, K. M., van Wijnen, A. J., McCabe, L. R., Lian, J. B., Stein, G. S., & Stein, J. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12887 · Cited by 135 · see citing works

BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction

Hens, J. R., Dann, P. R., Zhang, J., Harris, S. E., Robinson, G. W., & Wysolmerski, J. J. (2007) · Development · doi:10.1242/dev.000182 · Cited by 134 · see citing works

Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development

Han, J., Ishii, M., Bringas, P., Maas, R. L., Maxson, R. E., & Chai, Y. (2007) · Mechanisms of Development · doi:10.1016/j.mod.2007.06.006 · Cited by 134 · see citing works

Plasma-treated PET surfaces improve the biocompatibility of human endothelial cells

Ramires, P. A., Mirenghi, L., Romano, A. R., Palumbo, F., & Nicolardi, G. (2000) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(20000905)51:3 · Cited by 127 · see citing works

Dishevelled: A Mobile Scaffold Catalyzing Development

Malbon, C. C., & Wang, H. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)72002-0 · Cited by 105 · see citing works

Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis

Castro, C. H. D. M., Shin, C. S., Stains, J. P., Cheng, S., Sheikh, S., Mbalaviele, G., Szejnfeld, V. L., & Civitelli, R. (2004) · Journal of Cell Science · doi:10.1242/jcs.01133 · Cited by 105 · see citing works

The Effect of Varying Magnitudes of Whole-Body Vibration on Several Skeletal Sites in Mice

Christiansen, B., & Silva, M. J. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-006-9133-5 · Cited by 105 · see citing works

A RING Finger Protein Praja1 Regulates Dlx5-dependent Transcription through Its Ubiquitin Ligase Activity for the Dlx/Msx-interacting MAGE/Necdin Family Protein, Dlxin-1

Sasaki, A., Masuda, Y. M., Iwaï, K., Ikeda, K., & Watanabe, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109728200 · Cited by 104 · see citing works

Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA

Wu, L., Wu, H., Sangiorgi, F. O., Wu, N. L., Bell, J. R., Lyons, G. E., & Maxson, R. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00032-4 · Cited by 103 · see citing works

Synergistic Induction of Osteocalcin Gene Expression

Boudreaux, J. M., & Towler, D. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.13.7508 · Cited by 100 · see citing works

Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats.

Wang, F.-S., Ko, J.-Y., Lin, C.-L., Wu, H.-L., Ke, H.-J., & Tai, P.-J. (2007) · Bone · doi:10.1016/j.bone.2006.09.004 · Cited by 100 · see citing works

Precision and Accuracy of Peripheral Quantitative Computed Tomography (pQCT) in the Mouse Skeleton Compared With Histology and Microcomputed Tomography (μCT)

Schmidt, C., Priemel, M., Kohler, T., Weusten, A., Müller, R., Amling, M., & Eckstein, F. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.8.1486 · Cited by 97 · see citing works

Msx2 −/− transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosis

Aïoub, M., Lézot, F., Molla, M., Castaneda, B., Robert, B., Goubin, G., Néfussi, J. R., & Berdal, A. (2007) · Bone · doi:10.1016/j.bone.2007.07.023 · Cited by 91 · see citing works

Human cytomegalovirus (HCMV) immediate-early enhancer/promoter specificity during embryogenesis defines target tissues of congenital HCMV infection

Koedood, M., Fichtel, A., Meier, P., et al. (1995) · Journal of Virology · doi:10.1128/jvi.69.4.2194-2207.1995 · Cited by 90 · see citing works

Msx2 and Necdin Combined Activities Are Required for Smooth Muscle Differentiation in Mesoangioblast Stem Cells

Brunelli, S., Tagliafico, E., Angelis, F. G. D., Tonlorenzi, R., Baesso, S., Ferrari, S., Niinobe, M., Yoshikawa, K., Schwartz, R. J., Bozzoni, I., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000132747.12860.10 · Cited by 82 · see citing works

Regulation of Osteocalcin Gene Expression by a Novel Ku Antigen Transcription Factor Complex

Willis, D. M., Loewy, A. P., Charlton-Kachigian, N., Shao, J., Ornitz, D. M., & Towler, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206482200 · Cited by 81 · see citing works

Identification of mutations in the MSX2 homeobox gene in families affected with foramina parietalia permagna

Wuyts, W. A. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.8.1251 · Cited by 81 · see citing works

Canonical Wnt Signaling in Osteoblasts Is Required for Osteoclast Differentiation

Glass, D. A., & Karsenty, G. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1346.015 · Cited by 75 · see citing works

A Missense Mutation in the Mouse Col2a1 Gene Causes Spondyloepiphyseal Dysplasia Congenita, Hearing Loss, and Retinoschisis

Donahue, L. R., Chang, B., Mohan, S., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.9.1612 · Cited by 71 · see citing works

Reciprocal Temporospatial Patterns of Msx2 and Osteocalcin Gene Expression During Murine Odontogenesis

Bidder, M., Latifi, T. N., & Towler, D. A. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.4.609 · Cited by 70 · see citing works

Structure−Function Analysis of Msx2-Mediated Transcriptional Suppression

Newberry, E. P., Latifi, T. N., Battaile, J. T., & Towler, D. A. (1997) · Biochemistry · doi:10.1021/bi971008x · Cited by 70 · see citing works

Functional Antagonism between Msx2 and CCAAT/Enhancer-binding Protein α in Regulating the Mouse Amelogenin Gene Expression Is Mediated by Protein-Protein Interaction

Zhou, Y. L., Lei, Y., & Snead, M. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002031200 · Cited by 68 · see citing works

A Nonprostanoid EP4 Receptor Selective Prostaglandin E2 Agonist Restores Bone Mass and Strength in Aged, Ovariectomized Rats

Ke, H. Z., Crawford, D. T., Qi, H., Simmons, H. A., Owen, T. A., Paralkar, V. M., Li, M., Lu, B., GRASSER, W. A., Cameron, K. O., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051110 · Cited by 62 · see citing works

Expression profile of genes related to osteoclastogenesis in mouse growth plate and articular cartilage

Kishimoto, K., Kitazawa, R., Kurosaka, M., et al. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0103-z · Cited by 59 · see citing works

ROLE OF LEPTIN DURING CHILDHOOD GROWTH AND DEVELOPMENT

Roemmich, J. N., & Rogol, A. D. (1999) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70100-6 · Cited by 53 · see citing works

Expression of a human homeobox-containing gene is regulated by 1,25(OH)2D3 in bone cells

Hodgkinson, J. E., Davidson, C. L., Beresford, J. N., & Sharpe, P. T. (1993) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(93)90086-s · Cited by 51 · see citing works

Universal PCR Genotyping Assay that Achieves Single copy Sensitivity with Any Primer Pair

Stratman, J. L., Barnes, W. M., & Simon, T. C. (2003) · Transgenic Research · doi:10.1023/a:1024225408961 · Cited by 49 · see citing works

MINT, the Msx2 Interacting Nuclear Matrix Target, Enhances Runx2-dependent Activation of the Osteocalcin Fibroblast Growth Factor Response Element

Sierra, O. L., Cheng, S.-L., Loewy, A. P., Charlton-Kachigian, N., & Towler, D. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314098200 · Cited by 49 · see citing works

Nonstimulated Human Uncommitted Mesenchymal Stem Cells Express Cell Markers of Mesenchymal and Neural Lineages

Minguell, J. J., Fierro, F. A., EPUÑÁN, M. J., Erices, A. A., & Sierralta, W. D. (2005) · Stem Cells and Development · doi:10.1089/scd.2005.14.408 · Cited by 45 · see citing works

Gestational exposure to ethanol suppresses msx2 expression in developing mouse embryos

Rifas, L., Towler, D. A., & Avioli, L. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7549 · Cited by 45 · see citing works

Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal–ventral patterning of the limb

Adamska, M., MacDonald, B. T., & Meisler, M. H. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00114-8 · Cited by 38 · see citing works

Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb

Adamska, M., Billi, A. C., Cheek, S., & Meisler, M. H. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20437 · Cited by 29 · see citing works

Delivery of Small Interfering RNA to Mammalian Cells in Culture by Using Cationic Lipid⧸Polymer-Based Transfection Reagents

Brazas, R. M., & Hagstrom, J. E. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)92007-1 · Cited by 26 · see citing works

PIASxβ is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts

Ali, M. M., Yoshizawa, T., Ishibashi, O., Matsuda, A., Ikegame, M., Shimomura, J., Mera, H., Nakashima, K., & Kawashima, H. (2007) · Journal of Cell Science · doi:10.1242/jcs.005090 · Cited by 25 · see citing works

Conditional alleles of Msx1 and Msx2

Fu, H., Ishii, M., Gu, Y., & Maxson, R. E. (2007) · genesis · doi:10.1002/dvg.20316 · Cited by 23 · see citing works

Craniosynostosis associated with distal 5q‐trisomy: Further evidence that extra copy of MSX2 gene leads to craniosynostosis

Wang, J., Steinraths, M., Dang, L., Lomax, B. L., Eydoux, P., Stockley, T. L., Yong, S., & Allen, M. I. V. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31946 · Cited by 22 · see citing works

Enhancement of osteogenesis in vitro by a novel osteoblast differentiation-promoting compound, TAK-778, partly through the expression of Msx2

Gotoh, M., Notoya, K., Ienaga, Y., et al. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02183-0 · Cited by 13 · see citing works

Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

Vlashi, R., Zhang, X., Wu, M., & Chen, G. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.07.011 · Cited by 165 · see citing works

Targeted Reduction of Vascular <i>Msx1</i> and <i>Msx2</i> Mitigates Arteriosclerotic Calcification and Aortic Stiffness in <i>LDLR</i>-Deficient Mice Fed Diabetogenic Diets

Cheng, S.-L., Behrmann, A., Shao, J.-S., Ramachandran, B., Krchma, K., Bello Arredondo, Y., Kovacs, A., Mead, M., Maxson, R., & Towler, D. A. (2014) · Diabetes · doi:10.2337/db14-0326 · Cited by 77 · see citing works

Impact of an Altered Wnt1/β-Catenin Expression on Clinicopathology and Prognosis in Clear Cell Renal Cell Carcinoma

Kruck, S., Eyrich, C., Scharpf, M., Sievert, K.-D., Fend, F., Stenzl, A., & Bedke, J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140610944 · Cited by 70 · see citing works

Msx2 mediates the inhibitory action of TNF-α on osteoblast differentiation

Lee, H.-L., Yi, T., Woo, K. M., Ryoo, H.-M., Kim, G.-S., & Baek, J.-H. (2010) · Experimental and Molecular Medicine · doi:10.3858/emm.2010.42.6.045 · Cited by 64 · see citing works

Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis

Ma, Q., Wang, S., Xue, H., Ni, L., Yuan, P., Shen, Y., Zheng, B., Wang, Q., Zhang, J., Wang, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61938-0 · Cited by 15 · see citing works

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038 · see citing works

Context-Dependent Activation or Inhibition of Wnt-β-Catenin Signaling by Kremen

Cselenyi, C. S., & Lee, E. N. (2008) · Science Signaling · doi:10.1126/stke.18pe10 · Cited by 52 · see citing works

Mesd Is a Universal Inhibitor of Wnt Coreceptors LRP5 and LRP6 and Blocks Wnt/β-Catenin Signaling in Cancer Cells

Lü, W., Liu, C., Thottassery, J. V., Bu, G., & Li, Y. (2010) · Biochemistry · doi:10.1021/bi1001486 · Cited by 53 · see citing works

Lack of WNT Pathway Co-Receptors as a Possible Reason for Chronic Lymphoctic Leukemia (CLL) Cells Resistance to Dickkopf-1 (DKK1).

Filipovich, A., Gandhirajan, R. K., Gehrke, I., et al. (2009) · Blood · doi:10.1182/blood.v114.22.1598.1598

Reduction of the Wnt Inhibitor Dkk1 Correlates With Improved Bone Mechanical and Morphological Properties in Mice

Joiner, D. M., MacDonald, B. T., He, X., et al. (2007) · ASME Summer Bioengineering Conference (SBC) · doi:10.1115/sbc2007-175478