The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
MILI, a PIWI-interacting RNA-binding Protein, Is Required for Germ Line Stem Cell Self-renewal and Appears to Positively Regulate Translation
Open accessAbstract
The Argonaute/PIWI protein family consists of Argonaute and PIWI subfamilies. Argonautes function in RNA interference and micro-RNA pathways; whereas PIWIs bind to PIWI-interacting RNAs and regulate germ line development, stem cell maintenance, epigenetic regulation, and transposition. However, the role of PIWIs in mammalian stem cells has not been demonstrated, and molecular mechanisms mediated by PIWIs remain elusive. Here we show that MILI, a murine PIWI protein, is expressed in the cytoplasm of testicular germ line stem cells, spermatogonia, and early spermatocytes, where it is enriched in chromatoid bodies. MILI is essential for the self-renewing division and differentiation of germ line stem cells but does not affect initial establishment of the germ line stem cell population at 7 days postpartum. Furthermore, MILI forms a stable RNA-independent complex with eIF3a and associates with the eIF4E- and eIF4G-containing m7G cap-binding complex. In isolated 7 days postpartum seminiferous tubules containing mostly germ line stem cells, the mili mutation has no effect on the cellular mRNA level yet significantly reduces the rate of protein synthesis. These observations indicate that MILI may positively regulate translation and that such regulation is required for germ line stem cell self-renewal.
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Cites
A germline-specific class of small RNAs binds mammalian Piwi proteins
Girard, A., Sachidanandam, R., Hannon, G. J., & Carmell, M. A. (2006) · Nature · doi:10.1038/nature04917 · Cited by 1,762
A novel class of small RNAs bind to MILI protein in mouse testes
Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
Self-citationA large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis
Dragon, F., Gallagher, J. E. G., Compagnone-Post, P. A., Mitchell, B. M., Porwancher, K. A., Wehner, K. A., Wormsley, S., Settlage, R. E., Shabanowitz, J., Osheim, Y., et al. (2002) · Nature · doi:10.1038/nature00769 · Cited by 688
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2
Vasudevan, S., & Steitz, J. A. (2007) · Cell · doi:10.1016/j.cell.2007.01.038 · Cited by 656
Drosophila PIWI associates with chromatin and interacts directly with HP1a
Brower-Toland, B., Findley, S. D., Jiang, L., Liu, L., Yin, H., Dus, M., Zhou, P., Elgin, S. C. R., & Lin, H. (2007) · Genes & Development · doi:10.1101/gad.1564307 · Cited by 350
Self-citationSarot, E., Payen-Groschêne, G., Bucheton, A., & Pélisson, A. (2004) · Genetics · doi:10.1534/genetics.166.3.1313 · Cited by 251
Cited by
Juliano, C., Wang, J., & Lin, H. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132541 · Cited by 374
Self-citationWatanabe, T., Chuma, S., Yamamoto, Y., Kuramochi-Miyagawa, S., Totoki, Y., Toyoda, A., Hoki, Y., Fujiyama, A., Shibata, T., Sado, T., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.005 · Cited by 305
Self-citationFunayama, N., Nakatsukasa, M., Mohri, K., Masuda, Y., & Agata, K. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00413.x · Cited by 116
The stem cell system in demosponges: Insights into the origin of somatic stem cells
Funayama, N. (2010) · Development, Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01162.x · Cited by 95
Correction: Germline Stem Cell Gene PIWIL2 Mediates DNA Repair through Relaxation of Chromatin
Yin, D.-T., Wang, Q., Chen, L., Liu, M.-Y., Han, C., Yan, Q., Shen, R., He, G., Duan, W., Li, J.-J., et al. (2011) · PLoS ONE · doi:10.1371/annotation/2c1c26ac-ee7e-417d-9852-4d2995ad102b · Cited by 19
Metadata
- Authors
- Unhavaithaya, Y., Hao, Y., Beyret, E., Yin, H., Kuramochi-Miyagawa, S., Nakano, T., & Lin, H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 284
- Issue
- 10
- Pages
- 6507-6519
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2002708668
- Cited by
- 222
- References
- 6
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Unhavaithaya, Y., Hao, Y., Beyret, E., Yin, H., Kuramochi-Miyagawa, S., Nakano, T., & Lin, H. (2009). MILI, a PIWI-interacting RNA-binding Protein, Is Required for Germ Line Stem Cell Self-renewal and Appears to Positively Regulate Translation. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m809104200
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