Cited by 197RNA and protein synthesis mechanismsMitochondrial Function and PathologyRNA modifications and cancer

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The Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episode Syndrome-associated Human Mitochondrial tRNALeu(UUR) Mutation Causes Aminoacylation Deficiency and Concomitant Reduced Association of mRNA with Ribosomes

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Chomyn, Anne, Enriquez, José Antonio, Micol, Vicente, Fernandez-Silva, Patricio, Attardi, Giuseppe·2000·Journal of Biological Chemistry

DOI 10.1074/jbc.m908734199

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Abstract

The pathogenetic mechanism of the mitochondrial tRNA(Leu(UUR)) A3243G transition associated with the mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome has been investigated in transmitochondrial cell lines constructed by transfer of mutant mitochondrial DNA (mtDNA)-carrying mitochondria from three genetically unrelated MELAS patients or of isogenic wild-type mtDNA-carrying organelles into human mtDNA-less cells. An in vivo footprinting analysis of the mtDNA segment within the tRNA(Leu(UUR)) gene that binds the transcription termination factor failed to reveal any difference in occupancy of sites or qualitative interaction with the protein between mutant and wild-type mtDNAs. Cell lines nearly homoplasmic for the mutation exhibited a strong (70-75%) reduction in the level of aminoacylated tRNA(Leu(UUR)) and a decrease in mitochondrial protein synthesis rate. The latter, however, did not show any significant correlation between synthesis defect of the individual polypeptides and number or proportion of UUR codons in their mRNAs, suggesting that another step, other than elongation, may be affected. Sedimentation analysis in sucrose gradient showed a reduction in size of the mitochondrial polysomes, while the distribution of the two rRNA components and of the mRNAs revealed decreased association of mRNA with ribosomes and, in the most affected cell line, pronounced degradation of the mRNA associated with slowly sedimenting structures. Therefore, several lines of evidence indicate that the protein synthesis defect in A3243G MELAS mutation-carrying cells is mainly due to a reduced association of mRNA with ribosomes, possibly as a consequence of the tRNA(Leu(UUR)) aminoacylation defect.

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Authors: Chomyn, A., Enriquez, J. A., Micol, V., Fernandez-Silva, P., & Attardi, G.
Affiliations: California Institute of Technology (US)
Corresponding author: Chomyn, Anne
ORCID: Micol, Vicente
Attardi, Giuseppe
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2000-06
Volume: 275
Issue: 25
Pages: 19198-19209
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m908734199
OpenAlex: W2124207622
Cited by: 197
References: 60
Citations by year: 2026: 2 · 2025: 2 · 2024: 9 · 2023: 8 · 2022: 2 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 6 · 2013: 9 · 2012: 9
FWCI: 3.86
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7432 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Institutes of Health (GM-11726)
National Institute of General Medical Sciences (GM11726)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Keywords: MELAS, mitochondrial translation, mitochondrial myopathy, mitochondrial DNA, mRNA degradation, transcription termination factor
MeSH terms: Acylation, Base Sequence, Cell Line, DNA, Mitochondrial, DNA, Ribosomal, Humans, Mitochondria, Mutation, Ribosomes, RNA, Messenger, RNA, Transfer, Leu, Protein Biosynthesis, MELAS Syndrome, DNA Footprinting

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The Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episode Syndrome-associated Human Mitochondrial tRNALeu(UUR) Mutation Causes Aminoacylation Deficiency and Concomitant Reduced Association of mRNA with Ribosomes

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