The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Detergents as Tools in Membrane Biochemistry
Open accessAbstract
Detergents are invaluable tools for studying membrane proteins. However, these deceptively simple, amphipathic molecules exhibit complex behavior when they self-associate and interact with other molecules. The phase behavior and assembled structures of detergents are markedly influenced not only by their unique chemical and physical properties but also by concentration, ionic conditions, and the presence of other lipids and proteins. In this minireview, we discuss the various aggregate forms detergents assume and some misconceptions about their structure. The distinction between detergents and the membrane lipids that they may (or may not) replace is emphasized in the most recent high resolution structures of membrane proteins. Detergents are clearly friends and foes, but with the knowledge of how they work, we can use the increasing variety of detergents to our advantage.
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Cites
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Cited by
Proteomics of Integral Membrane ProteinsTheory and Application
Speers, A. E., & Wu, C. C. (2007) · Chemical Reviews · doi:10.1021/cr068286z · Cited by 325
Role of cholesterol in the function and organization of G-protein coupled receptors
Pucadyil, T. J., & Chattopadhyay, A. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.02.002 · Cited by 296
Methods for samples preparation in proteomic research
Bodzon-Kulakowska, A., Bierczynska-Krzysik, A., Dylag, T., Drabik, A., Suder, P., Noga, M., Jarzebinska, J., & Silberring, J. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.10.040 · Cited by 254
Dissipative self-assembly, competition and inhibition in a self-reproducing protocell model
Post, E. A. J., & Fletcher, S. P. (2020) · Chemical Science · doi:10.1039/d0sc02768e · Cited by 57
Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters
Claxton, D. P., Jagessar, K. L., & Mchaourab, H. S. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166959 · Cited by 29
Metadata
- Authors
- Garavito, R. M., & Ferguson-Miller, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 276
- Issue
- 35
- Pages
- 32403-32406
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2002996832
- Cited by
- 560
- References
- 40
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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