The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Beyond the Canonical 20 Amino Acids: Expanding the Genetic Lexicon
Open accessAbstract
The ability to genetically encode unnatural amino acids beyond the common 20 has allowed unprecedented control over the chemical structures of recombinantly expressed proteins. Orthogonal aminoacyl-tRNA synthetase/tRNA pairs have been used together with nonsense, rare, or 4-bp codons to incorporate >50 unnatural amino acids into proteins in Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, and mammalian cell lines. This has allowed the expression of proteins containing amino acids with novel side chains, including fluorophores, post-translational modifications, metal ion chelators, photocaged and photocross-linking moieties, uniquely reactive functional groups, and NMR, IR, and x-ray crystallographic probes.
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Cites
Adding New Chemistries to the Genetic Code
Liu, C. C., & Schultz, P. G. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.105824 · Cited by 1,725
Self-citationA General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins
Noren, C. J., Anthony-Cahill, S. J., Griffith, M. C., & Schultz, P. G. (1989) · Science · doi:10.1126/science.2649980 · Cited by 1,019
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Perez, H. L., Cardarelli, P. M., Deshpande, S., Gangwar, S., Schroeder, G. M., Vite, G. D., & Borzilleri, R. M. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2013.11.004 · Cited by 470
Enzymatic Modification of N-Terminal Proline Residues Using Phenol Derivatives
Maza, J. C., Bader, D. L. V., Xiao, L., Marmelstein, A. M., Brauer, D. D., ElSohly, A. M., Smith, M. J., Krska, S. W., Parish, C. A., & Francis, M. B. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10845 · Cited by 57
Metadata
- Authors
- Young, T. S., & Schultz, P. G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 285
- Issue
- 15
- Pages
- 11039-11044
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1976254260
- Cited by
- 354
- References
- 2
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Young, T. S., & Schultz, P. G. (2010). Beyond the Canonical 20 Amino Acids: Expanding the Genetic Lexicon. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.r109.091306
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
