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Carbon-Oxygen Hydrogen Bonding in Biological Structure and Function
Open accessAbstract
Carbon-oxygen (CH···O) hydrogen bonding represents an unusual category of molecular interactions first documented in biological structures over 4 decades ago. Although CH···O hydrogen bonding has remained generally underappreciated in the biochemical literature, studies over the last 15 years have begun to yield direct evidence of these interactions in biological systems. In this minireview, we provide a historical context of biological CH···O hydrogen bonding and summarize some major advancements from experimental studies over the past several years that have elucidated the importance, prevalence, and functions of these interactions. In particular, we examine the impact of CH···O bonds on protein and nucleic acid structure, molecular recognition, and enzyme catalysis and conclude by exploring overarching themes and unresolved questions regarding unconventional interactions in biomolecular structure.
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Cites
The Hydrogen Bond in the Solid State
Steiner, T. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020104)41:1<48::aid-anie48>3.0.co;2-u · Cited by 6,247
Desiraju, G., & Steiner, T. (2001) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198509707.001.0001 · Cited by 3,791
The C−H···O Hydrogen Bond: Structural Implications and Supramolecular Design
Desiraju, G. R. (1996) · Accounts of Chemical Research · doi:10.1021/ar950135n · Cited by 1,870
A tetrameric DNA structure with protonated cytosine-cytosine base pairs
Gehring, K., Leroy, J.-L., & Guéron, M. (1993) · Nature · doi:10.1038/363561a0 · Cited by 1,239
Fundamental Properties of the CH···O Interaction: Is It a True Hydrogen Bond?
Gu, Y., Kar, T., & Scheiner, S. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991795g · Cited by 1,008
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
Kruidenier, L., Chung, C.-W., Cheng, Z., Liddle, J., Che, K., Joberty, G., Bantscheff, M., Bountra, C., Bridges, A., Diallo, H., et al. (2012) · Nature · doi:10.1038/nature11262 · Cited by 950
The Nature of the Hydrogen Bond
Gilli, G., & Gilli, P. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199558964.001.0001 · Cited by 819
The Occurence of C–H · · · O Hydrogen Bonds in Proteins
Derewenda, Z. S., Lee, L., & Derewenda, U. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1995.0492 · Cited by 568
Distinction between the weak hydrogen bond and the van der Waals interaction
Steiner, T., & Desiraju, G. R. (1998) · Chemical Communications · doi:10.1039/a708099i · Cited by 556
Senes, A., Ubarretxena-Belandia, I., & Engelman, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161280798 · Cited by 476
Cited by
Chemical and Biochemical Perspectives of Protein Lysine Methylation
Luo, M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00008 · Cited by 284
Structural basis for Klf4 recognition of methylated DNA
Liu, Y., Olanrewaju, Y. O., Zheng, Y., Hashimoto, H., Blumenthal, R. M., Zhang, X., & Cheng, X. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku134 · Cited by 99
Sharma, S., Nehru, B., & Saini, A. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.06.011 · Cited by 48
Metadata
- Authors
- Horowitz, S., & Trievel, R. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 287
- Issue
- 50
- Pages
- 41576-41582
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2011778857
- Cited by
- 338
- References
- 46
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
