The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Cα—H⋅⋅⋅O hydrogen bond: A determinant of stability and specificity in transmembrane helix interactions
Open accessAbstract
The Cα—H⋅⋅⋅O hydrogen bond has been given little attention as a determinant of transmembrane helix association. Stimulated by recent calculations suggesting that such bonds can be much stronger than has been supposed, we have analyzed 11 known membrane protein structures and found that apparent carbon α hydrogen bonds cluster frequently at glycine-, serine-, and threonine-rich packing interfaces between transmembrane helices. Parallel right-handed helix–helix interactions appear to favor Cα—H⋅⋅⋅O bond formation. In particular, Cα—H⋅⋅⋅O interactions are frequent between helices having the structural motif of the glycophorin A dimer and the GxxxG pair. We suggest that Cα—H⋅⋅⋅O hydrogen bonds are important determinants of stability and, depending on packing, specificity in membrane protein folding.
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Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E., et al. (2000) · Science · doi:10.1126/science.289.5480.739 · Cited by 5,637
Cited by
Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs
Senes, A., Engel, D. E., & DeGrado, W. F. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.07.007 · Cited by 434
Self-citationDrugging Membrane Protein Interactions
Yin, H., & Flynn, A. D. (2016) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-092115-025322 · Cited by 339
Computational Design of Peptides That Target Transmembrane Helices
Yin, H., Slusky, J. S., Berger, B. W., Walters, R. S., Vilaire, G., Litvinov, R. I., Lear, J. D., Caputo, G. A., Bennett, J. S., & DeGrado, W. F. (2007) · Science · doi:10.1126/science.1136782 · Cited by 289
Patel, S. K., Lavasanifar, A., & Choi, P. (2009) · Biomacromolecules · doi:10.1021/bm900512h · Cited by 59
Zhang, Y., Bartz, R., Grigoryan, G., Bryant, M., Aaronson, J., Beck, S., Innocent, N., Klein, L., Procopio, W., Tucker, T., et al. (2015) · ACS Chemical Biology · doi:10.1021/cb500759p · Cited by 23
Metadata
- Authors
- Senes, A., Ubarretxena-Belandia, I., & Engelman, D. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-07-31
- Volume
- 98
- Issue
- 16
- Pages
- 9056-9061
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2128805758
- Cited by
- 476
- References
- 2
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Senes, A., Ubarretxena-Belandia, I., & Engelman, D. M. (2001). The Cα—H⋅⋅⋅O hydrogen bond: A determinant of stability and specificity in transmembrane helix interactions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.161280798
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