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The M2 Proton Channels of Influenza A and B Viruses
Open accessAbstract
Influenza A virus and influenza B virus are two different enveloped, negative stranded RNA viruses that cause epidemic infections. The virion (virus particle) of each virus contains a small integral membrane protein (A/M2 and BM2, respectively) that functions as a proton channel and is essential to viral replication. These proton channels are of interest because they are among the smallest bona fide ion channel proteins (with the properties of ion selectivity and activation), and they succeed in accomplishing the same function with only a meager similarity in primary amino acid sequence.
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Cited by
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Influenza virus activates inflammasomes via its intracellular M2 ion channel
Ichinohe, T., Pang, I. K., & Iwasaki, A. (2010) · Nature Immunology · doi:10.1038/ni.1861 · Cited by 631
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
Cady, S. D., Schmidt-Rohr, K., Wang, J., Soto, C. S., DeGrado, W. F., & Hong, M. (2010) · Nature · doi:10.1038/nature08722 · Cited by 615
Influenza virus-induced lung injury: pathogenesis and implications for treatment
Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186214 · Cited by 503
Luo, W., & Hong, M. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9096219 · Cited by 90
Metadata
- Authors
- Pinto, L. H., & Lamb, R. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 281
- Issue
- 14
- Pages
- 8997-9000
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2155734592
- Cited by
- 459
- References
- 0
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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