The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.
Influenza virus-induced lung injury: pathogenesis and implications for treatment
Open accessAbstract
The influenza viruses are some of the most important human pathogens, causing substantial seasonal and pandemic morbidity and mortality. In humans, infection of the lower respiratory tract of can result in flooding of the alveolar compartment, development of acute respiratory distress syndrome and death from respiratory failure. Influenza-mediated damage of the airway, alveolar epithelium and alveolar endothelium results from a combination of: 1) intrinsic viral pathogenicity, attributable to its tropism for host airway and alveolar epithelial cells; and 2) a robust host innate immune response, which, while contributing to viral clearance, can worsen the severity of lung injury. In this review, we summarise the molecular events at the virus–host interface during influenza virus infection, highlighting some of the important cellular responses. We discuss immune-mediated viral clearance, the mechanisms promoting or perpetuating lung injury, lung regeneration after influenza-induced injury, and recent advances in influenza prevention and therapy.
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Cites
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Self-citationEffects of air pollutants on the transmission and severity of respiratory viral infections
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Metadata
- Authors
- Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2015-03-18
- Volume
- 45
- Issue
- 5
- Pages
- 1463-1478
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2106772621
- Cited by
- 503
- References
- 202
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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